Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study

Panteleimon G. Takis | Jordan J. Clark | Michael J. Murphy | Megan L. Nagel | C. A. Shaw | P. Horby | T. Fletcher | M. Beadsworth | M. Shankar-Hari | M. Roberts | P. Klenerman | A. Maclean | W. Lim | C. Gamble | A. Rambaut | J. Scott-Brown | W. Paxton | L. Marsh | J. Baillie | W. Greenhalf | A. Mentzer | G. Barlow | Eglė Savičiūtė | R. Tedder | G. Cooke | N. Wrobel | Joyce Mitchell | D. Roberts | J. Nguyen-Van-Tam | M. O’Shea | P. Jennings | P. Olliaro | Matthew Lewis | M. Palmarini | M. Noursadeghi | Z. Takáts | F. Post | S. McDonald | N. Pattison | J. McLauchlan | J. Child | Q. Mok | S. Garg | S. Roberts | L. Merson | P. Takis | M. Dumas | A. Finn | Gonçalo D. S. Correia | T. Whitehouse | C. Snelson | P. Dark | K. Tatham | T. Szakmany | T. Solomon | E. Thomson | C. Palmieri | W. Barclay | M. Zambon | J. Hiscox | A. Garg | M. Twagira | C. Evans | Christopher Davis | D. Latawiec | S. Metelmann | J. Dunning | R. Thwaites | P. Openshaw | B. Brennan | Maria Mancini | A. Docherty | M. Semple | E. Gkrania-Klotsas | L. Sigfrid | A. Meynert | L. Vincent-Smith | I. Welters | A. Walden | R. Jensen | R. Pius | M. Wijesinghe | J. Tanianis-Hughes | G. Koshy | M. Lyttle | M. Nelson | A. Whittington | M. Wiselka | Clive Graham | J. Minton | D. Chadwick | D. Bogaert | P. Lillie | L. Turtle | Krishanthi S Subramaniam | M. Peters | Isabel García-Dorival | H. Cox | V. Sancho-Shimizu | T. Drake | S. Sriskandan | K. Chechi | D. Agranoff | R. Vancheeswaran | Maria-Teresa Cutino-Moguel | A. Lake | S. Ijaz | C. Russell | T. Foster | G. Koduri | L. Murphy | Catherine Hartley | G. Pollakis | P. Bothma | M. Ostermann | L. Hodgson | D. Fullerton | C. Green | C. Cosgrove | Richard Smith | L. Booth | Rishi K. Gupta | L. Maslen | C. Sands | S. Knight | A. Ho | G. Carson | C. Fairfield | S. Halpin | H. Hardwick | K. Holden | C. Jackson | L. Norman | O. Swann | A. Hormis | L. McEvoy | C. Summers | D. Hawcutt | P. Dyer | S. Clohisey | S. Panchatsharam | Mbiye Mpenge | R. Brittain-Long | D. Stuart | Sean S. Keating | D. Wootton | B. Ryan | K. Mortimore | J. Pepperell | J. Harrison | J. Bernatoniene | A. Elliott | N. Spittle | C. Thompson | S. Laha | P. Andrikopoulos | C. Kerrison | Tristan Dyer | G. Leeming | S. Douthwaite | C. Bassford | E. Harrison | J. Cupitt | H. Reschreiter | A. Burtenshaw | P. Collini | D. Robertson | Jordan Thomas | S. Barnass | R. Mulla | S. Dervisevic | S. Kegg | Tim Reynolds | M. Chand | R. Shears | Susan Jain | Ross Hendry | A. Law | Joanne Dalton | A. Filipe | N. Barrett | W. Oosthuyzen | S. Lant | G. Rousseau | S. Basude | Sarah J. Cole | N. Bulteel | A. Workman | O. Koch | P. Papineni | S. Laird | N. Price | S. Bakshi | Nigel Chee | Arthur J Goldsmith | T. Jones | J. Sizer | A. Evans | J. Armstrong | B. Small | Louise Cooper | V. Shaw | E. Hardy | N. Rae | T. Prince | S. McCafferty | Innocent G Asiimwe | C. Donohue | J. Moon | D. Price | T. Leiner | D. Plotkin | P. Whittaker | R. Wake | P. Ridley | C. Eziefula | N. Carlucci | Benjamin Bach | S. Khoo | S. Moore | J. Scott | A. Thompson | Fiona Griffiths | D. Murphy | James Lee | M. Girvan | M. Connor | Murray Wham | K. A. Ahmed | M. Ashworth | S. Barlow | Benjamin W. A. Catterall | Oslem Dincarslan | Chris Dunn | L. Finch | L. Fisher | P. Gunning | C. Jones | Shadia Khandaker | K. King | Robyn T Kiy | Chrysa Koukorava | L. Lavelle-Langham | Lauren Lett | Lucia A. Livoti | N. Miah | J. Middleton | E. Murphy | Rebekah Penrice-Randal | J. Pilgrim | W. Reynolds | Debby Sales | Agnieska Szemiel | Aislynn Taggart | E. Trochu | E. Wilcock | J. E. Zhang | K. Adeniji | K. Agwuh | D. Ail | A. Alegria | Brian Angus | A. Ashish | Doug Atkinson | S. Bari | D. Baxter | N. Best | T. Burden | Vikki Caruth | D. Chambler | S. Chukkambotla | Tom Clark | Chris Dawson | P. Donnison | Ahilanadan Dushianthan | C. Fegan | J. Godden | S. Hartshorn | D. Harvey | Peter Havalda | M. Hobrok | M. Jacobs | A. Kaliappan | V. Kasipandian | Michael R. Kelsey | J. Kendall | I. Kerslake | Susan G. Larkin | James Limb | J. Little | M. MacMahon | E. Macnaughton | Ravish Mankregod | Huw Masson | Elijah Matovu | K. McCullough | R. Mcewen | M. Meda | G. Mills | M. Mirfenderesky | K. Mohandas | Elinoor Moore | P. Morgan | C. Morris | S. Moses | T. Nagarajan | I. Otahal | M. Pais | Hassan Paraiso | M. Phull | S. Pintus | J. Pooni | R. Prout | Neil Richardson | T. Saluja | Aarti S. Shah | Prad Shanmuga | Anil Sharma | A. Shawcross | N. Staines | T. Stambach | R. Stewart | P. Subudhi | Robert Thompson | A. Tridente | D. Tupper-Carey | Nick Vallotton | S. Visuvanathan | A. Vuylsteke | S. Waddy | Martin Williams | Lawrence Wilson | S. Winchester | A. Wolverson | B. Yates | Peter Young | Beatrice Alex | Anthonia Osagie | Chloe Donohue | Daniella A. Lefteri | L. Flaherty | Nicole Maziere | E. Cass | Anthony Holmes | H. Massey | K. Morrice | Sarah Sarah | A. Carracedo | B. Patel | Thushani de Silva | Ingrid DuRand | L. Norris | Brian J. Angus | M. Williams | Michael K. Sullivan | T. D. Silva | K. Bullock | Libby van Tonder | A. Riad | V. Linnett | Sonia Liggi | J. Berridge | A. Rose | Erin L. Aldera | Danai Papakonstantinou | A. Drummond | C. Egan | M. Olanipekun | Julian L Griffin | Elaine Hardy | Lisa Norman | K. Mclean | Emily A. Clarke | F. Soares | R. L. Jensen | B. Angus | B. Alex | Lewis W. S. Fisher | J. Limb | Emily Clarke | David L. Robertson | P. Havalda | L. Cooper | R. Thompson | K. Ahmed | Sarah McCafferty | M. Sullivan | Caroline J. Sands | Andrew Law | James Scott-Brown | Annette Lake | Daniel R Plotkin | Brendan J. Ryan | Christopher Jones | J. Mitchell | Chrisopher Fegan | A. Goldsmith | E. Matovu | A. Shah | N. Vallotton | Nicholas A. Barrett | Gary Leeming | Mbiye A Mpenge | S. Jain | I. DuRand | Laura J. Booth | Katherine Mortimore | Darell Tupper-Carey | L. Tonder | T. R. Jones | A. Dushianthan | Janet R Harrison | Taranprit Saluja

[1]  P. Tubert-Bitter,et al.  Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study , 2020, The Lancet Respiratory Medicine.

[2]  S. Solomon,et al.  Cardiovascular implications of COVID-19 versus influenza infection: a review , 2020, BMC Medicine.

[3]  S. Garg,et al.  Risk for In-Hospital Complications Associated with COVID-19 and Influenza — Veterans Health Administration, United States, October 1, 2018–May 31, 2020 , 2020, MMWR. Morbidity and mortality weekly report.

[4]  L. Maurer,et al.  Gastrointestinal Complications in Critically Ill Patients With and Without COVID-19. , 2020, JAMA.

[5]  S. Ávila-Ríos,et al.  Acute kidney injury in patients with severe COVID-19 in Mexico , 2020, medRxiv.

[6]  M. Hauptmann,et al.  Clinical course and factors associated with outcomes among 1904 patients hospitalized with COVID-19 in Germany: an observational study , 2020, Clinical Microbiology and Infection.

[7]  Jordan J. Clark,et al.  Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score , 2020, BMJ.

[8]  Eike Nagel,et al.  Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) , 2020, JAMA cardiology.

[9]  Angelo Carfì,et al.  Persistent Symptoms in Patients After Acute COVID-19. , 2020, JAMA.

[10]  Maria Thom,et al.  The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings , 2020, Brain : a journal of neurology.

[11]  COVIDSurg Collaborative Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study , 2020 .

[12]  A. Acquaviva,et al.  Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients , 2020, Scientific Reports.

[13]  J. Schattenberg,et al.  Liver injury in COVID-19: The current evidence , 2020, United European gastroenterology journal.

[14]  P. Horby,et al.  Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study , 2020, BMJ.

[15]  M. Ramakers,et al.  High incidence of venous thromboembolic events in anticoagulated severe COVID‐19 patients , 2020, Journal of Thrombosis and Haemostasis.

[16]  M. Drazner,et al.  Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome , 2020, Circulation.

[17]  N. Stafford Covid-19: Why Germany’s case fatality rate seems so low , 2020, BMJ.

[18]  J. Xiang,et al.  Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study , 2020, The Lancet.

[19]  J. Prowle,et al.  Acute kidney injury and adverse outcomes of critical illness: correlation or causation? , 2019, Clinical kidney journal.

[20]  P. Thomas,et al.  Influenza virus-related critical illness: pathophysiology and epidemiology , 2019, Critical Care.

[21]  Eyal Oren,et al.  Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 , 2017, The Lancet. Neurology.

[22]  Haniye Sadat Sajadi,et al.  Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 , 2018, The Lancet.

[23]  H. Whitaker,et al.  Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland , 2018, European Respiratory Journal.

[24]  D. Newby,et al.  Long-Term Outcomes in Patients With Type 2 Myocardial Infarction and Myocardial Injury , 2017, Circulation.

[25]  T. Walsh,et al.  Early troponin I in critical illness and its association with hospital mortality: a cohort study , 2017, Critical Care.

[26]  Christopher X. Wong,et al.  AKI and Long-Term Risk for Cardiovascular Events and Mortality. , 2017, Journal of the American Society of Nephrology : JASN.

[27]  S. Wild,et al.  Five-Year Mortality and Hospital Costs Associated with Surviving Intensive Care. , 2016, American journal of respiratory and critical care medicine.

[28]  L. Forni,et al.  Acute kidney injury: short-term and long-term effects , 2016, Critical Care.

[29]  E. Klein,et al.  The frequency of influenza and bacterial coinfection: a systematic review and meta‐analysis , 2016, Influenza and other respiratory viruses.

[30]  P. Horby,et al.  Open source clinical science for emerging infections , 2013, The Lancet Infectious Diseases.

[31]  Charles Maynard,et al.  Cerebral Performance Category and Long-Term Prognosis Following Out-of-Hospital Cardiac Arrest* , 2013, Critical care medicine.

[32]  A. Vince,et al.  Liver involvement during influenza infection: perspective on the 2009 influenza pandemic , 2011, Influenza and other respiratory viruses.

[33]  Norbert Lameire,et al.  Notice , 2012, Kidney International Supplements.

[34]  D. Needham,et al.  The functional costs of ICU survivorship. Collaborating to improve post-ICU disability. , 2011, American journal of respiratory and critical care medicine.

[35]  Alejandro Rodríguez,et al.  Acute kidney injury in critical ill patients affected by influenza A (H1N1) virus infection , 2011, Critical care.

[36]  J. Rello,et al.  Acute kidney injury in critical ill patients affected by influenza A ( H 1 N 1 ) virus infection , 2011 .

[37]  G. Rubenfeld,et al.  Critical care and the global burden of critical illness in adults , 2010, The Lancet.

[38]  P. Harris,et al.  Research electronic data capture (REDCap) - A metadata-driven methodology and workflow process for providing translational research informatics support , 2009, J. Biomed. Informatics.

[39]  H. Krumholz,et al.  Long-term prognosis of acute kidney injury after acute myocardial infarction. , 2008, Archives of internal medicine.

[40]  S. Pocock,et al.  The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. , 2007, Preventive medicine.

[41]  Matthias Egger,et al.  The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies , 2007, PLoS medicine.

[42]  D. Heyland,et al.  Survivors of acute respiratory distress syndrome: Relationship between pulmonary dysfunction and long-term health-related quality of life* , 2005, Critical care medicine.