Voltammetric determination of salicylic acid in pharmaceuticals formulations of acetylsalicylic acid.

The electrochemical oxidation of salicylic acid (SA) has been studied on a glassy carbon electrode using cyclic voltammetry and differential pulse voltammetric (DPV) method. SA gives a single irreversible oxidation wave over the wide pH range studied. The irreversibility of the electrode process was verified by different criteria. The mechanism of oxidation is discussed. Using differential pulse voltammetry, SA yielded a well-defined voltammetric response in Britton-Robinson buffer solution, pH 2.37 at 1.088V (versus Ag/AgCl). The method was linear over the SA concentration range: 1-60mugml(-1). The method was successfully applied for the analysis of SA as a hydrolysis product, in solid pharmaceutical formulations containing acetylsalicylic acid (ASA).

[1]  J. Mather,et al.  Minimisation of salicylic acid formation during preparation of aspirin products for analysis by high-performance liquid chromatography , 1984 .

[2]  V. Andrisano,et al.  Application of high-performance liquid chromatography with diode-array detection and on-line post-column photochemical derivatization to the determination of analgesics. , 1996, Journal of chromatography. A.

[3]  A. Vidal,et al.  Salicylate-selective electrode based on a biomimetic guanidinium ionophore. , 1997, Analytical chemistry.

[4]  J. Hart,et al.  Voltammetric behaviour of salicylic acid at a glassy carbon electrode and its determination in serum using liquid chromatography with amperometric detection. , 1991, The Analyst.

[5]  Horace Traubel.  Collect , 1904 .

[6]  W. E. Lange,et al.  Fluorometric determination of acetylsalicylic acid and salicylic acid in blood. , 1966, Journal of pharmaceutical sciences.

[7]  R. C. Weast.  CRC Handbook of Chemistry and Physics , 1973 .

[8]  C. Kelly.  Determination of the decomposition of aspirin. , 1970, Journal of pharmaceutical sciences.

[9]  Stephen E. Creager,et al.  An easily constructed salicylate-ion-selective electrode for use in the instructional laboratory , 1995 .

[10]  R. Adams,et al.  Anodic oxidation pathways of phenolic compounds Part 2. Stepwise electron transfers and coupled hydroxylations , 1975 .

[11]  R. S. Nicholson,et al.  Theory of Stationary Electrode Polarography. Single Scan and Cyclic Methods Applied to Reversible, Irreversible, and Kinetic Systems. , 1964 .

[12]  W. C. Purdy,et al.  The determination of slicylic acid and its metabolites in blood plasma by high-performance liquid chromatography with amperometric detection , 1983 .

[13]  J. Garrido,et al.  Flow Injection Determination of Acetylsalicylic Acid in Pharmaceutical Preparations with an Amperometric Detector , 2000 .

[14]  A. M. Díaz,et al.  A simple solid phase spectrofluorimetric method combined with flow analysis for the rapid determination of salicylamide and salicylic acid in pharmaceutical samples , 1999 .

[15]  A. Pereira.  Flow injection spectrophotometric determination of acetylsalicylic acid in tablets after on-line microwave-assisted alkaline hydrolysis , 1998 .

[16]  G. Dryhurst,et al.  Electrochemical oxidation of 5,6-diaminouracil an investigation by thin-layer spectroelectrochemistry , 1977 .

[17]  R. Barnaby,et al.  A strategy for validation of bioanalytical methods. , 1996, Journal of pharmaceutical and biomedical analysis.

[18]  E. Laviron.  Electrochemical reactions with protonations at equilibrium: Part VIII. The 2 e, 2H+ reaction (nine-member square scheme) for a surface or for a heterogeneous reaction in the absence of disproportionation and dimerization reactions , 1983 .

[19]  J. Levine.  Analysis of acetylsalicylic acid and acetylsalicylic acid tablets. , 1961, Journal of pharmaceutical sciences.

[20]  Shahida B. Niazi,et al.  High-performance liquid chromatographic determination of aspirin and its metabolites in plasma and urine. , 1983, Journal of pharmaceutical sciences.

[21]  R. S. Nicholson,et al.  Theory of Stationary Electrode Polarography for a Chemical Reaction Coupled between Two Charge Transfers. , 1965 .

[22]  J. Richards,et al.  Electrochemical oxidation of 2,4,6-tri-tert-butylphenol , 1975 .

[23]  G. H. Schenk,et al.  Fluorescence of acetylsalicylic acid in solution and its measurement in presence of salicylic acid. , 1970, Analytical chemistry.

[24]  D. S. Polcyn,et al.  Multistep Charge Transfers in Stationary Electrode Polarography. , 1966 .

[25]  R. C. Weast.  Handbook of chemistry and physics , 1973 .

[26]  L. Goodman,et al.  The Pharmacological Basis of Therapeutics , 1941 .

[27]  L. Kubota,et al.  Acetylsalicylic acid determination in pharmaceutical samples by FIA-potentiometry using a salicylate-sensitive tubular electrode with an ethylene-vinyl acetate membrane , 1998 .

[28]  P. Mazzeo,et al.  Determination of salicylic acid in acetylsalicylic acid by second derivative u. v.‐spectrophotometry , 1982, The Journal of pharmacy and pharmacology.

[29]  M. C. Miras,et al.  Anodic oxidation of N-N-dimethyl-1-napthylamine (DMN) in acetonitrile. On a novel homogeneous redox reaction between DMN and the reaction product , 1988 .

[30]  P. Chen,et al.  Simultaneous high-performance liquid chromatography assay of acetylsalicylic acid and salicylic acid in film-coated aspirin tablets. , 1984, Journal of chromatography.

[31]  A. Villari,et al.  Simultaneous spectrophotometric determination in solid phase of aspirin and its impurity salicylic acid in pharmaceutical formulations. , 1992, Journal of pharmaceutical sciences.

[32]  K. Verma,et al.  Spectrophotometric determination of aspirin by transacetylation of 4-aminophenol. , 1986, Analytical chemistry.

[33]  R. D. Kirchhoefer,et al.  Aspirin--a national survey I: Semiautomated determination of aspirin in bulk and tablet formulations and salicyclic acid in tablet formulations. , 1980, Journal of pharmaceutical sciences.

[34]  J. Savéant,et al.  Disproportionation and ECE mechanisms—I. Theoretical analysis. Relationships for linear sweep voltammetry☆ , 1968 .

[35]  R. D. Kirchhoefer.  Simultaneous determination of aspirin and salicylic acid in bulk aspirin and in plain, buffered, and enteric-coated tablets by high-pressure liquid chromatography with UV and fluorescence detectors. , 1980, Journal of pharmaceutical sciences.

[36]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[37]  S. Patai,et al.  The Chemistry of the quinonoid compounds , 1974 .