Iohexol and Metrizamide in Lumbar Myelography

In routine lumbar myelography carried out in 100 patients iohexol (n=50) produced side effects in fewer patients (p<0.03), especially meningeal and cerebral (p<0.03), and among these a lower rate of headache (p<0.07), than did metrizamide. The overall frequency of afflicted patients (50% after iohexol and 72% after metrizamide) was high, mainly because of deliberate inclusion of patients with a high risk of side effects in the investigation. The side effects recorded up to six hours after the administration of the contrast medium were less frequent when using iohexol. If severe side effects are present at 24 hours or appear thereafter, as occurred in a few of the present patients after iohexol, surgical treatment or discharge of the patient is in some cases unnecessarily delayed.

[1]  P. Turski,et al.  Lumbar myelography with iohexol and metrizamide. A comparative multicenter prospective study. , 1984, Investigative radiology.

[2]  S. Ekholm,et al.  Lumbar Myelography with Metrizamide in Rabbits , 1984, Acta radiologica: diagnosis.

[3]  S. Ekholm,et al.  Lumbar Myelography with Iohexol and Metrizamide , 1984, Acta radiologica: diagnosis.

[4]  T. Laike,et al.  Psychic Changes following Myelography with Metrizamide and Iohexol , 1984, Acta radiologica: diagnosis.

[5]  S. Gebarski,et al.  Iohexol versus metrizamide for lumbar myelography: double-blind trial. , 1984, AJR. American journal of roentgenology.

[6]  K. Nestvold,et al.  Comparison of iohexol with metrizamide in myelography. , 1984, Radiology.

[7]  O. Eldevik,et al.  First Clinical Trial with Iohexol in Myelography , 1983, Acta radiologica: diagnosis.

[8]  B. Kendall,et al.  Clinical Trial of Iohexol in Lumbar Myelography , 1983, Acta radiologica: diagnosis.

[9]  J. Hannerz,et al.  Experience with Iohexol in Lumbar Myelography , 1983, Acta radiologica: diagnosis.

[10]  P. Nakstad,et al.  Functional Lumbar Myelography with Iohexol , 1983, Acta radiologica: diagnosis.

[11]  B. Kendall,et al.  Documentation of a New Contrast Medium for the Subarachnoid Space , 1983, Acta radiologica: diagnosis.

[12]  B. Kendall,et al.  Clinical trial of iohexol for lumbar myelography. , 1983, The British journal of radiology.

[13]  J. Bentson,et al.  Comparative advantages of small- and large-dose metrizamide myelography. , 1983, AJR. American journal of roentgenology.

[14]  B. Kendall,et al.  Iohexol in lumbar myelography: preliminary results from an open, noncomparative multicenter clinical study. , 1983, AJNR. American journal of neuroradiology.

[15]  K. Wolf,et al.  Iohexol--Omnipaque. Clinical experience with a new non-ionic contrast medium. , 1983, Acta radiologica. Supplementum.

[16]  R. Bryan,et al.  Neurotoxicity of iohexol: a new nonionic contrast medium. , 1982, Radiology.

[17]  O. Hauge,et al.  Neuropsychologic reactions and other side effects after metrizamide myelography. , 1982, AJR. American journal of roentgenology.

[18]  E. M. Laasonen,et al.  Die Nebenwirkungen von Metrizamid und Meglumin-Iocarmat bei der lumbalen Myelographie , 1977 .

[19]  L. Irstam,et al.  Adverse Effects of Lumbar Myelography with Amipaque and Dimer-X , 1976, Acta radiologica: diagnosis.

[20]  T. Hindmarsh.  Lumbar Myelography with Meglumine Iocarmate and Metrizamide , 1975, Acta radiologica: diagnosis.

[21]  P. Amundsen,et al.  Lumbar radiculography with metrizamide. A nonionic water-soluble contrast medium. , 1975, Radiology.

[22]  L. Irstam.  Side Effects of Water-Soluble Contrast Media in Lumbar Myelography , 1973, Acta radiologica: diagnosis.