Engineering and ethical perspectives in synthetic biology

The applications of synthetic biology will involve the release of artificial life forms into the environment. These organisms will present unique safety challenges that need to be addressed by researchers and regulators to win public engagement and support.

[1]  H. G. Khorana,et al.  Total synthesis of a gene , 1979, Resonance.

[2]  J. Doyle,et al.  Robust and optimal control , 1995, Proceedings of 35th IEEE Conference on Decision and Control.

[3]  Commentary: safety of participants in non-therapeutic research must be ensured. , 1998, BMJ.

[4]  U. Alon,et al.  Robustness in bacterial chemotaxis , 2022 .

[5]  M. Ehrenberg,et al.  Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[6]  John Doyle,et al.  Complexity and robustness , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[7]  S. Shen-Orr,et al.  Networks Network Motifs : Simple Building Blocks of Complex , 2002 .

[8]  Guy Plunkett,et al.  Engineering a reduced Escherichia coli genome. , 2002, Genome research.

[9]  Neil A. Manson.  Formulating the Precautionary Principle , 2002 .

[10]  J. Doyle,et al.  Reverse Engineering of Biological Complexity , 2002, Science.

[11]  S. Shen-Orr,et al.  Network motifs: simple building blocks of complex networks. , 2002, Science.

[12]  Robert Winston,et al.  Playing God? , 2003, Nature.

[13]  C. Sunstein.  Laws of Fear: Acknowledgments , 2005 .

[14]  George Church,et al.  Let us go forth and safely multiply , 2005, Nature.

[15]  Victor de Lorenzo,et al.  Genetically modified organisms for the environment: stories of success and failure and what we have learned from them. , 2005, International microbiology : the official journal of the Spanish Society for Microbiology.

[16]  Timothy S. Ham,et al.  Production of the antimalarial drug precursor artemisinic acid in engineered yeast , 2006, Nature.

[17]  Sandra D. Mitchell.  Modularity—More Than a Buzzword? , 2006 .

[18]  L. Hood,et al.  Reverse Engineering of Biological Complexity , 2007 .

[19]  L. Alphey,et al.  Female-specific insect lethality engineered using alternative splicing , 2007, Nature Biotechnology.

[20]  Christl A Donnelly,et al.  Late-acting dominant lethal genetic systems and mosquito control , 2007, BMC Biology.

[21]  Eduardo Sontag,et al.  Modular cell biology: retroactivity and insulation , 2008, Molecular systems biology.

[22]  Timothy S. Ham,et al.  Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels. , 2008, Current opinion in biotechnology.

[23]  Richard G. Smith,et al.  A review of biosensors and biologically-inspired systems for explosives detection. , 2008, The Analyst.

[24]  J. Collins,et al.  DIVERSITY-BASED, MODEL-GUIDED CONSTRUCTION OF SYNTHETIC GENE NETWORKS WITH PREDICTED FUNCTIONS , 2009, Nature Biotechnology.

[25]  Steve Clarke,et al.  New Technologies, Common Sense and the Paradoxical Precautionary Principle , 2009 .

[26]  Filippa Lentzos.  Synthetic Biology in the Social Context: The UK Debate to Date , 2009 .

[27]  Markus Huppenbauer,et al.  Synthetic organisms and living machines , 2009, Systems and Synthetic Biology.

[28]  J. Chin,et al.  Synthesis of orthogonal transcription-translation networks , 2009, Proceedings of the National Academy of Sciences.

[29]  Priscilla E. M. Purnick,et al.  The second wave of synthetic biology: from modules to systems , 2009, Nature Reviews Molecular Cell Biology.

[30]  Thomas H Segall-Shapiro,et al.  Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome , 2010, Science.

[31]  G. Vinnicombe,et al.  Fundamental limits on the suppression of molecular fluctuations , 2010, Nature.

[32]  Thomas Douglas,et al.  Synthetic biology and the ethics of knowledge , 2010, Journal of Medical Ethics.

[33]  S. Lee,et al.  Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers , 2010, Biotechnology and bioengineering.

[34]  James M Clomburg,et al.  Biofuel production in Escherichia coli: the role of metabolic engineering and synthetic biology , 2010, Applied Microbiology and Biotechnology.

[35]  Mauricio Barahona,et al.  Switchable genetic oscillator operating in quasi-stable mode , 2009, Journal of The Royal Society Interface.

[36]  M. di Bernardo,et al.  Evolving enhanced topologies for the synchronization of dynamical complex networks. , 2010, Physical review. E, Statistical, nonlinear, and soft matter physics.

[37]  Domitilla Del Vecchio,et al.  Signaling properties of a covalent modification cycle are altered by a downstream target , 2010, Proceedings of the National Academy of Sciences.

[38]  Sang Yup Lee,et al.  Construction and optimization of synthetic pathways in metabolic engineering. , 2010, Current opinion in microbiology.

[39]  Orkun S. Soyer,et al.  Evolution of response dynamics underlying bacterial chemotaxis , 2011, BMC Evolutionary Biology.

[40]  Korstanje Maximiliano,et al.  Laws of Fear: Beyond the Precautionary Principle , 2011 .

[41]  Domitilla Del Vecchio,et al.  Long signaling cascades tend to attenuate retroactivity. , 2011, Biophysical journal.

[42]  Mauricio Barahona,et al.  Transient dynamics around unstable periodic orbits in the generalized repressilator model. , 2010, Chaos.

[43]  Science snipes at Oxitec transgenic-mosquito trial , 2011, Nature Biotechnology.

[44]  null null,et al.  New Directions. The Ethics of Synthetic Biology and Emerging Technologies. Executive Summary and Recommendations , 2012 .

[45]  Mi-Ching Tsai,et al.  Robust and Optimal Control , 2014 .