Autoxidation of amyloid precursor protein and formation of reactive oxygen species.

[1]  Shin Lin,et al.  Metal ion chaperone function of the soluble Cu(I) receptor Atx1. , 1997, Science.

[2]  R. Casareno,et al.  The Copper Chaperone for Superoxide Dismutase* , 1997, The Journal of Biological Chemistry.

[3]  C. Masters,et al.  Reactive oxygen species and Alzheimer's disease. , 1997, Biochemical pharmacology.

[4]  R. Klausner,et al.  Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae * , 1997, The Journal of Biological Chemistry.

[5]  Andrew P. Dobson,et al.  Hopes for the Future: Restoration Ecology and Conservation Biology , 1997 .

[6]  Bing Zhou,et al.  hCTR1: a human gene for copper uptake identified by complementation in yeast. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[7]  M. Gurney,et al.  The Copper Chelator d‐Penicillamine Delays Onset of Disease and Extends Survival in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis , 1997, The European journal of neuroscience.

[8]  E. Stadtman,et al.  A Familial Amyotrophic Lateral Sclerosis-associated A4V Cu,Zn-Superoxide Dismutase Mutant Has a Lower Km for Hydrogen Peroxide , 1997, The Journal of Biological Chemistry.

[9]  C. Masters,et al.  The metabolism of the amyloid precursor protein of Alzheimer's disease and dietary zinc , 1997 .

[10]  Jonathan D. Smith,et al.  Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides , 1996, Nature Genetics.

[11]  D. Selkoe,et al.  Amyloid β-Protein and the Genetics of Alzheimer's Disease* , 1996, The Journal of Biological Chemistry.

[12]  J. Bonifacino,et al.  Copper‐dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis. , 1996, The EMBO journal.

[13]  E. Stadtman,et al.  A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[14]  M. Linder,et al.  Copper biochemistry and molecular biology. , 1996, The American journal of clinical nutrition.

[15]  C. Masters,et al.  The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I) , 1996, Science.

[16]  D. Bredesen,et al.  Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis , 1996, Science.

[17]  C. Masters,et al.  Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I (*) , 1996, The Journal of Biological Chemistry.

[18]  K. Iqbal,et al.  Alzheimer's disease : biology, diagnosis, and therapeutics , 1996 .

[19]  G. Multhaup,et al.  Alzheimer's disease: genesis of amyloid. , 1996, Ciba Foundation symposium.

[20]  P. Lockhart,et al.  Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux. , 1995, Human molecular genetics.

[21]  B. Hyman,et al.  LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation , 1995, Cell.

[22]  D. Munoz,et al.  Qualitative and Quantitative Differences in Senile Plaque Dystrophie Neurites of Alzheimer's Disease and Normal Aged Brain , 1995, Journal of neuropathology and experimental neurology.

[23]  C. Masters,et al.  Proteolytic Processing of Alzheimer's Disease βA4 Amyloid Precursor Protein in Human Platelets (*) , 1995, The Journal of Biological Chemistry.

[24]  D. Borchelt,et al.  An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria , 1995, Neuron.

[25]  E. Ikonen,et al.  Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites , 1995, Journal of neuroscience research.

[26]  D. Selkoe,et al.  Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons , 1995, The Journal of cell biology.

[27]  W. E. Nostrand.  Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid β-Protein precursor , 1995 .

[28]  Robert H. Brown,et al.  Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice , 1995, Cell.

[29]  C. Masters,et al.  Interaction between the zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP) , 1994, FEBS letters.

[30]  C. Masters,et al.  Rapid induction of Alzheimer A beta amyloid formation by zinc. , 1994, Science.

[31]  C. Masters,et al.  The βA4 amyloid precursor protein binding to copper , 1994 .

[32]  S. Squazzo,et al.  Evidence that production and release of amyloid beta-protein involves the endocytic pathway. , 1994, The Journal of biological chemistry.

[33]  M. Gurney,et al.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. , 1994, Science.

[34]  C. Masters,et al.  Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants , 1994, Journal of neuroscience research.

[35]  D. Small,et al.  A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[36]  G. Multhaup.  Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycans. , 1994, Biochimie.

[37]  C. Masters,et al.  A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. , 1993, The Journal of biological chemistry.

[38]  H. Maeda,et al.  Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme. , 1992, The Journal of biological chemistry.

[39]  B. Greenberg,et al.  Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins. , 1992, Laboratory investigation; a journal of technical methods and pathology.

[40]  D. Selkoe,et al.  Amyloid β-peptide is produced by cultured cells during normal metabolism , 1992, Nature.

[41]  C. Masters,et al.  The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth , 1992, Neuron.

[42]  Y. Komiyama,et al.  Purification of factor XIa inhibitor from human platelets. , 1992, Thrombosis research.

[43]  N. Robakis,et al.  Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor. , 1992, The Journal of biological chemistry.

[44]  K. Breen.  APP-collagen interaction is mediated by a heparin bridge mechanism. , 1992, Molecular and chemical neuropathology.

[45]  E. D. Harris.  Copper Transport: An Overview , 1991, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[46]  D. Price,et al.  Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits. , 1990, The American journal of pathology.

[47]  D. Price,et al.  Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. , 1990, Science.

[48]  T. Oltersdorf,et al.  Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts , 1989, Cell.

[49]  S. Percival,et al.  Ascorbate enhances copper transport from ceruloplasmin into human K562 cells. , 1989, Journal of NutriLife.

[50]  C. Bouras,et al.  Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques , 1989, Neuroscience Letters.

[51]  G. Multhaup,et al.  Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. , 1988, The EMBO journal.

[52]  J. Klinman,et al.  Dopamine beta-hydroxylase of adrenal chromaffin granules: structure and function. , 1988, Annual review of biochemistry.

[53]  I. Fridovich,et al.  The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: inactivation of the enzyme. , 1975, Biochemistry.

[54]  W. Rich,et al.  Total reconstitution of copper-zinc superoxide dismutase. , 1974, The Journal of biological chemistry.