Bovine papillomavirus infections in animals

Bovine papillomaviruses (BPV) are DNA oncogenic viruses inducing hyperplastic benign lesions of both cutaneous and mucosal epithelia in cattle. Six (BPV 1-6) different viral genotypes have been characterized so far; they are all strictly specie-specific even if BPV 1/2 may also infect horses inducing fibroblastic tumors. The benign lesions may regress or develop to cancer once the virus synergizes with environmental carcinogenic co-factors. Among these the bracken fern is the most extensively studied. The BPV associated tumors have veterinary and agriculture relevance in its own right but they have also been studied as relevant model of human papillomavirus (HPV). Recent insights into BPV biology open new fields of speculation about the role of these viruses in inducing neoplastic transformation of cells other than epithelial.

[1]  S. Sonnino,et al.  Sialic acid and GM3 ganglioside expression in papillomavirus-associated urinary bladder tumours of cattle with chronic enzootic haematuria. , 2007, Journal of comparative pathology.

[2]  M. Campo.  Bovine papillomavirus: old system, new lessons? , 2006 .

[3]  L. Nasir,et al.  Expression of cell cycle associated proteins cyclin A, CDK-2, p27kip1 and p53 in equine sarcoids. , 2005, Cancer letters.

[4]  M. Campo,et al.  The E5 protein of papillomaviruses , 2002 .

[5]  R. Schlegel,et al.  Expression of a transforming gene (E5) of bovine papillomavirus in sarcoids obtained from horses. , 2001, American journal of veterinary research.

[6]  S. Griffey,et al.  Bovine papillomavirus DNA in neoplastic and nonneoplastic tissues obtained from horses with and without sarcoids in the western United States. , 2001, American journal of veterinary research.

[7]  R. Ducatelle,et al.  PCR detection of bovine papilloma virus DNA in superficial swabs and scrapings from equine sarcoids. , 2001, Veterinary journal.

[8]  D. Knottenbelt,et al.  Manual of equine dermatology , 1999 .

[9]  J. Sundberg,et al.  The nonhuman (animal) papillomaviruses: host range, epitope conservation, and molecular diversity , 1996 .

[10]  J. Sundberg.  Papillomavirus Infections in Animals , 1987 .

[11]  W. Jarrett.  The natural history of bovine papillomavirus infections , 1985 .

[12]  W. Lancaster.  Apparent lack of integration of bovine papillomavirus DNA in virus-induced equine and bovine tumor cells and virus-transformed mouse cells. , 1981, Virology.

[13]  E. B. Wilson.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. , 1919, Science.