Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

[1]  V. Dixit,et al.  Phosphorylation of NLRC4 is critical for inflammasome activation , 2012, Nature.

[2]  Bino John,et al.  miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes , 2012, Proceedings of the National Academy of Sciences.

[3]  C. Dinarello,et al.  The Rate of Interleukin-1β Secretion in Different Myeloid Cells Varies with the Extent of Redox Response to Toll-like Receptor Triggering* , 2011, The Journal of Biological Chemistry.

[4]  F. Liew,et al.  Regulation of type 17 helper T-cell function by nitric oxide during inflammation , 2011, Proceedings of the National Academy of Sciences.

[5]  Denis Gris,et al.  Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling , 2011, Nature Immunology.

[6]  S. Ryter,et al.  Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. , 2011, Nature immunology.

[7]  J. Stamler,et al.  The SNO-proteome: causation and classifications. , 2011, Current opinion in chemical biology.

[8]  J. Tschopp,et al.  A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.

[9]  Yan Zeng,et al.  Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production , 2010, The Journal of Immunology.

[10]  V. Dixit,et al.  Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella , 2010, The Journal of experimental medicine.

[11]  Egil Lien,et al.  NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals , 2010, Nature.

[12]  T. McMahon,et al.  Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. , 2010, Free radical biology & medicine.

[13]  M. Kastan,et al.  The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. , 2010, Immunity.

[14]  D. Kastner,et al.  Autoinflammatory Disease Reloaded: A Clinical Perspective , 2010, Cell.

[15]  E. Alnemri,et al.  Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome* , 2010, The Journal of Biological Chemistry.

[16]  J. Tschopp,et al.  The Inflammasomes , 2010, Cell.

[17]  Y. Wang,et al.  Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling1 , 2009, The Journal of Immunology.

[18]  E. Alnemri,et al.  Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1 , 2009, The Journal of Immunology.

[19]  Fuping Zhang,et al.  A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. , 2009, Immunity.

[20]  J. Tschopp,et al.  Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence , 2009, Nature.

[21]  J. Ting,et al.  The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. , 2009, Immunity.

[22]  Akiko Iwasaki,et al.  Inflammasome recognition of influenza virus is essential for adaptive immune responses , 2009, The Journal of experimental medicine.

[23]  Richard A. Flavell,et al.  Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants , 2008, Nature.

[24]  J. Tschopp,et al.  Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica , 2008, Science.

[25]  F. Liew,et al.  Nitric oxide induces CD4+CD25+ Foxp3− regulatory T cells from CD4+CD25− T cells via p53, IL-2, and OX40 , 2007, Proceedings of the National Academy of Sciences.

[26]  A. Cauwels Nitric oxide in shock. , 2007, Kidney international.

[27]  E. Alnemri,et al.  The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation , 2007, Cell Death and Differentiation.

[28]  F. Martinon,et al.  Gout-associated uric acid crystals activate the NALP3 inflammasome , 2006, Nature.

[29]  V. Dixit,et al.  Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf , 2004, Nature.

[30]  J. Bakker,et al.  Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock* , 2004, Critical care medicine.

[31]  A. Rawlingson Nitric oxide, inflammation and acute burn injury. , 2003, Burns : journal of the International Society for Burn Injuries.

[32]  R. Cross,et al.  Nitric Oxide in Inflammatory Bowel Disease , 2003, Inflammatory bowel diseases.

[33]  Christian Bogdan,et al.  Nitric oxide and the immune response , 2001, Nature Immunology.

[34]  Santiago Lamas,et al.  Nitrosylation The Prototypic Redox-Based Signaling Mechanism , 2001, Cell.

[35]  C. Cooper,et al.  Nitric oxide synthases: structure, function and inhibition. , 2001, The Biochemical journal.

[36]  C. Bogdan,et al.  The role of nitric oxide in innate immunity , 2000, Immunological reviews.

[37]  C. Tribble,et al.  Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice. , 1998, The American journal of physiology.

[38]  S. Abramson,et al.  The role of nitric oxide in inflammation and immunity. , 1998, Arthritis and rheumatism.

[39]  T. Billiar,et al.  Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme). , 1998, Journal of immunology.

[40]  T. Billiar,et al.  Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. , 1997, Biochemical and biophysical research communications.

[41]  C. Nathan,et al.  Nitric oxide and macrophage function. , 1997, Annual review of immunology.

[42]  C. Szabó,et al.  BENEFICIAL VERSUS DETRIMENTAL EFFECTS OF NITRIC OXIDE SYNTHASE INHIBITORS IN CIRCULATORY SHOCK LESSONS LEARNED FROM EXPERIMENTAL AND CLINICAL STUDIES , 1997, Shock.

[43]  O. Smithies,et al.  Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[44]  J. Weinberg,et al.  Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. , 1995, Blood.

[45]  I. Charles,et al.  Altered immune responses in mice lacking inducible nitric oxide synthase , 1995, Nature.

[46]  C. Nathan,et al.  Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase , 1995, Cell.

[47]  S Moncada,et al.  Nitric oxide synthases in mammals. , 1994, The Biochemical journal.

[48]  S. Moncada,et al.  The L-arginine-nitric oxide pathway. , 1993, The New England journal of medicine.

[49]  F. Murad,et al.  Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. , 1977, Proceedings of the National Academy of Sciences of the United States of America.