Endometriosis and Infertility

Endometriosis is an estrogen‐dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0.5–5% in fertile and 25–40% in infertile women. The optimal choice of management for endometriosis‐associated infertility remains obscure. Removal or suppression of endometrial deposits by medical or surgical means constitutes the basis of endometriosis management. Current evidence indicates that suppressive medical treatment of endometriosis does not benefit fertility and should not be used for this indication alone. Surgery is probably efficacious for all stages of the disease. Controlled ovarian hyperstimulation with intrauterine insemination is recommended in early‐stage and surgically corrected endometriosis when pelvic anatomy is normal. In advanced cases, in vitro fertilization is a treatment of choice, and its success may be augmented with prolonged gonadotropin‐releasing hormone analog treatment. Further randomized clinical trials focusing on diverse etiopathogenic mechanisms and therapeutic innovation are necessary to find more conclusive, evidence‐based answers regarding this enigmatic disease.

[1]  C. Farquhar,et al.  Laparoscopic surgery for subfertility associated with endometriosis. , 2014, The Cochrane database of systematic reviews.

[2]  A. Arıcı,et al.  Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. , 2007, Fertility and sterility.

[3]  Julie Brown,et al.  Ovulation suppression for endometriosis for women with subfertility , 2007 .

[4]  P. Viganò,et al.  Genetics of endometriosis: current status and prospects. , 2007, Frontiers in bioscience : a journal and virtual library.

[5]  D. Spiegelman,et al.  Natural hair color and the incidence of endometriosis. , 2006, Fertility and sterility.

[6]  Robert Greb,et al.  ESHRE guideline for the diagnosis and treatment of endometriosis. , 2005, Human reproduction.

[7]  G. Halis,et al.  Endometriosis and Inflammation in Infertility , 2004, Annals of the New York Academy of Sciences.

[8]  D. Spiegelman,et al.  In utero exposures and the incidence of endometriosis. , 2004, Fertility and sterility.

[9]  W. Willett,et al.  Reproductive History and Endometriosis Among Premenopausal Women , 2004, Obstetrics and gynecology.

[10]  D. Spiegelman,et al.  Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. , 2004, American journal of epidemiology.

[11]  I. Brosens.  Endometriosis and the outcome of in vitro fertilization. , 2004, Fertility and sterility.

[12]  J. Donnez,et al.  Surgical management of endometriosis. , 2004, Best practice & research. Clinical obstetrics & gynaecology.

[13]  Robert N. Taylor,et al.  An evidence-based evaluation of endometriosis-associated infertility. , 2003, Endocrinology and metabolism clinics of North America.

[14]  C. Winkel.  Evaluation and Management of Women With Endometriosis , 2003, Obstetrics and gynecology.

[15]  M. Busacca,et al.  Ovarian endometriosis: from pathogenesis to surgical treatment , 2003, Current opinion in obstetrics & gynecology.

[16]  P. Vandekerckhove,et al.  Ovulation suppression for endometriosis. , 2003, The Cochrane database of systematic reviews.

[17]  T. D’Hooghe,et al.  Endometriosis and Subfertility: Is the Relationship Resolved? , 2003, Seminars in reproductive medicine.

[18]  I. Brosens,et al.  Endometriosis: modern surgical management to improve fertility. , 2003, Best practice & research. Clinical obstetrics & gynaecology.

[19]  W. Schoolcraft,et al.  Management of endometriosis-associated infertility. , 2003, Obstetrics and gynecology clinics of North America.

[20]  P. Vercellini,et al.  Management of ovarian endometriomas. , 2002, Human reproduction update.

[21]  W. Dmowski,et al.  Cycle-specific and cumulative fecundity in patients with endometriosis who are undergoing controlled ovarian hyperstimulation-intrauterine insemination or in vitro fertilization-embryo transfer. , 2002, Fertility and sterility.

[22]  S. Kropf,et al.  Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis. , 2002, Fertility and sterility.

[23]  W. Schoolcraft,et al.  Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis. , 2002, Fertility and sterility.

[24]  P. Vercellini,et al.  Serum dioxin concentrations and endometriosis: a cohort study in Seveso, Italy. , 2002, Environmental health perspectives.

[25]  K. Barnhart,et al.  Effect of endometriosis on in vitro fertilization. , 2002, Fertility and sterility.

[26]  A. Arıcı,et al.  New advances in the understanding of endometriosis related infertility. , 2002, Journal of reproductive immunology.

[27]  D. Cahill.  What is the optimal medical management of infertility and minor endometriosis? Analysis and future prospects. , 2002, Human reproduction.

[28]  B. Lessey.  Implantation Defects in Infertile Women with Endometriosis , 2002, Annals of the New York Academy of Sciences.

[29]  Y. Taketani,et al.  Role of Laparoscopy in the Treatment of Endometriosis-Associated Infertility , 2002, Gynecologic and Obstetric Investigation.

[30]  L. Álvarez-Gil,et al.  Raloxifene and endometriosis , 2002 .

[31]  M. Candiani,et al.  Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III-IV: a randomized controlled trial. , 2001, Human reproduction.

[32]  O. Bukulmez,et al.  The presence and extent of endometriosis do not effect clinical pregnancy and implantation rates in patients undergoing intracytoplasmic sperm injection. , 2001, European journal of obstetrics, gynecology, and reproductive biology.

[33]  H. Al-Inany.  Evidence may change with more trials: concepts to be kept in mind. , 2000, Human reproduction.

[34]  C. Simón,et al.  Impact of stage III-IV endometriosis on recipients of sibling oocytes: matched case-control study. , 2000, Fertility and sterility.

[35]  G. Russell,et al.  Predictors of success after embryo transfer: experience from a single provider. , 2000, American journal of obstetrics and gynecology.

[36]  E. Kujansuu,et al.  In vitro fertilization in patients with ovarian endometriomas , 2000, Acta obstetricia et gynecologica Scandinavica.

[37]  A. Arıcı,et al.  The relevance of the peritoneal fluid in endometriosis-associated infertility. , 1999, Human reproduction.

[38]  A. Shahar,et al.  Patients with stages III and IV endometriosis have a poorer outcome of in vitro fertilization-embryo transfer than patients with tubal infertility. , 1999, Fertility and sterility.

[39]  R. Schenken,et al.  Pathophysiology of endometriosis-associated infertility. , 1999, Clinical obstetrics and gynecology.

[40]  I. Georgiou,et al.  Association of estrogen receptor gene polymorphisms with endometriosis. , 1999, Fertility and sterility.

[41]  P Sismondi,et al.  A gonadotrophin‐releasing hormone agonist compared with expectant management after conservative surgery for symptomatic endometriosis , 1999, British journal of obstetrics and gynaecology.

[42]  M. Candiani,et al.  Effects of 3 month therapy with danazol after laparoscopic surgery for stage III/IV endometriosis: a randomized study. , 1999, Human reproduction.

[43]  Gruppo italiano per lo studio dell'endometriosi.  Ablation of lesions or no treatment in minimal–mild endometriosis in infertile women: a randomized trial , 1999 .

[44]  M. Candiani,et al.  Follow-up of laparoscopic treatment of stage III-IV endometriosis. , 1999, The Journal of the American Association of Gynecologic Laparoscopists.

[45]  R. Maheux,et al.  Characteristics Related to the Prevalence of Minimal or Mild Endometriosis in Infertile Women , 1998, Epidemiology.

[46]  S. Hamamah,et al.  Pre or post-operative medical treatment with nafarelin in stage III-IV endometriosis: a French multicenter study. , 1998, European journal of obstetrics, gynecology, and reproductive biology.

[47]  R. Raffaelli,et al.  Surgical treatment of recurrent endometriosis: laparotomy versus laparoscopy. , 1998, Human reproduction.

[48]  R. Maheux,et al.  Fecundity of infertile women with minimal or mild endometriosis and women with unexplained infertility. The Canadian Collaborative Group on Endometriosis. , 1998, Fertility and sterility.

[49]  R. Barbieri,et al.  Effects of Endometriomas on Ooccyte Quality, Embryo Quality, and Pregnancy Rates in In Vitro Fertilization Cycles: A Prospective, Case-Controlled Study , 1998, Journal of Assisted Reproduction and Genetics.

[50]  P. Ayotte,et al.  Organochlorine exposure and the risk of endometriosis. , 1998, Fertility and sterility.

[51]  D. Barlow,et al.  Endometriosis in monozygotic twins. , 1997, Fertility and sterility.

[52]  W. Heinrichs,et al.  Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis. , 1997, Fertility and sterility.

[53]  A. Haney.  Endometriosis-associated infertility , 1997 .

[54]  J. Balasch,et al.  Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: a pilot randomized clinical trial. , 1997, Human reproduction.

[55]  D. Guzick.  Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. , 1997, Journal of women's health.

[56]  Adamson Gd.  Treatment of Endometriosis-Associated Infertility , 1997, Seminars in reproductive endocrinology.

[57]  T. Tulandi,et al.  Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. , 1997, Fertility and sterility.

[58]  D. Spiegelman,et al.  Epidemiologic determinants of endometriosis: a hospital-based case-control study. , 1997, Annals of epidemiology.

[59]  Anita Nur Mayani,et al.  Dioxin concentrations in women with endometriosis. , 1997, Human reproduction.

[60]  Y. Soong,et al.  Life table analysis of pregnancy rates in women with moderate or severe endometriosis comparing danazol therapy after carbon dioxide laser laparoscopy plus electrocoagulation or laparotomy plus electrocoagulation versus danazol therapy only. , 1997, The Journal of the American Association of Gynecologic Laparoscopists.

[61]  H. Karube,et al.  Benefit of in vitro fertilization treatment for endometriosis-associated infertility. , 1996, Fertility and sterility.

[62]  Joan K. Morris,et al.  Factors that affect outcome of in-vitro fertilisation treatment , 1996, The Lancet.

[63]  L. Muzii,et al.  The impact of preoperative gonadotropin-releasing hormone agonist treatment on laparoscopic excision of ovarian endometriotic cysts. , 1996, Fertility and sterility.

[64]  A. Arıcı,et al.  The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program. , 1996, Fertility and sterility.

[65]  Z. Rosenwaks,et al.  Endometriosis: a stage by stage analysis--the role of in vitro fertilization. , 1995, Fertility and sterility.

[66]  H. Sangi-Haghpeykar,et al.  Epidemiology of Endometriosis Among Parous Women , 1995, Obstetrics and gynecology.

[67]  G. Adamson,et al.  Surgical treatment of endometriosis-associated infertility: meta-analysis compared with survival analysis. , 1994, American journal of obstetrics and gynecology.

[68]  L. Fedele,et al.  Postsurgical medical treatment of advanced endometriosis: results of a randomized clinical trial. , 1994, American journal of obstetrics and gynecology.

[69]  M. Nisolle,et al.  Ovarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage. , 1994, Fertility and sterility.

[70]  J. Becker,et al.  Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin , 1993 .

[71]  J. Collins,et al.  A quantitative overview of controlled trials in endometriosis-associated infertility. , 1993, Fertility and sterility.

[72]  A. Prentice.  Epidemiology of endometriosis. , 1993, BMJ.

[73]  M. Vessey,et al.  Epidemiology of endometriosis in women attending family planning clinics. , 1993, BMJ.

[74]  R. Shaw.  Treatment of endometriosis , 1992, The Lancet.

[75]  L. Fedele,et al.  Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis: a controlled randomized study. , 1992, Fertility and sterility.

[76]  I. Cooke,et al.  Donor insemination — a look to the future , 1991, Fertility and sterility.

[77]  A. Luciano,et al.  A comparative analysis of the cycle fecundity rates associated with combined human menopausal gonadotropin (hMG) and intrauterine insemination (IUI) versus either hMG or IUI alone. , 1991, Fertility and sterility.

[78]  G. Badger,et al.  A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis. , 1990, Fertility and sterility.

[79]  I. Cooke,et al.  Donor insemination--a look to the future. , 1990 .

[80]  K. Moghissi,et al.  Comparison of different treatment modalities of endometriosis in infertile women. , 1987, Fertility and sterility.

[81]  B. S. Verkauf.  Incidence, symptoms, and signs of endometriosis in fertile and infertile women. , 1987, The Journal of the Florida Medical Association.

[82]  D. E. Houston,et al.  Incidence of pelvic endometriosis in Rochester, Minnesota, 1970-1979. , 1987, American Journal of Epidemiology.

[83]  D. Olive,et al.  Analysis of sequential treatment protocols for endometriosis-associated infertility. , 1986, American journal of obstetrics and gynecology.

[84]  Chatman Dl.  Endometriosis and the black woman. , 1976 .

[85]  M. Parsanezhad,et al.  Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: a prospective, double-blind, randomized, placebo-controlled study. , 2007, Journal of minimally invasive gynecology.

[86]  D. Cahill,et al.  Differences in time to natural conception between women with unexplained infertility and infertile women with minor endometriosis. , 2004, Human reproduction.

[87]  R. Kistner,et al.  Endometriosis and infertility. , 2004, Fertility and sterility.

[88]  T. D’Hooghe,et al.  Mini symposium on pathogenesis of endometriosis and treatment of endometriosis-associated subfertility. Introduction: the endometriosis enigma. , 2002, Human reproduction update.

[89]  T. Child,et al.  Endometriosis: aetiology, pathogenesis and treatment. , 2001, Drugs.

[90]  D. Barlow,et al.  Ovarian response to repeated controlled stimulation in in-vitro fertilization cycles in patients with ovarian endometriosis. , 2000, Human reproduction.

[91]  C. Simón,et al.  Follicular hormonal environment and embryo quality in women with endometriosis. , 2000, Human reproduction update.

[92]  J. Uly,et al.  Laparoscopic Surgery in Infertile Women with Minimal or Mild Endometriosis , 1998 .

[93]  R. Maheux,et al.  LAPAROSCOPIC SURGERY IN INFERTILE WOMEN WITH MINIMAL OR MILD ENDOMETRIOSIS , 1998 .

[94]  D. L. Chatman.  Endometriosis and the black woman. , 1976, The Journal of reproductive medicine.

[95]  D. Olive.  Endometriosis : does surgery make a difference ? , 2022 .