Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs.
暂无分享,去创建一个
H. Bayır | Y. Tyurina | V. Tyurin | V. Kagan | S. Samovich | K. Mikulska-Ruminska | Thiliban Manivarma | Aleksandr A Kapralov | Andy P VanDemark | Wieslaw Nowak | Ivet Bahar
[1] J. Tobias,et al. Ferroptosis of tumour neutrophils causes immune suppression in cancer , 2022, Nature.
[2] Junhong Lü,et al. Membrane phosphatidylserine allosterically regulates the cytosolic phospholipase A2 activity via an electrostatic-switch mechanism. , 2022, Soft Matter.
[3] Varnavas D. Mouchlis,et al. Lipoprotein-associated phospholipase A2: A paradigm for allosteric regulation by membranes , 2022, Proceedings of the National Academy of Sciences.
[4] D. Tieleman,et al. Insights into lipid-protein interactions from computer simulations , 2021, Biophysical Reviews.
[5] D. Girelli,et al. Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19? , 2021, Antioxidants.
[6] I. Bahar,et al. NO● Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis , 2021, International journal of molecular sciences.
[7] Ivet Bahar,et al. ProDy 2.0: increased scale and scope after 10 years of protein dynamics modelling with Python , 2021, Bioinform..
[8] K. Bae,et al. Lipid Metabolism and Ferroptosis , 2021, Biology.
[9] A. Belaidi,et al. Ferroptosis: mechanisms and links with diseases , 2021, Signal Transduction and Targeted Therapy.
[10] B. Stockwell,et al. Ferroptosis: mechanisms, biology and role in disease , 2021, Nature Reviews Molecular Cell Biology.
[11] P. Nelson,et al. Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease , 2021, Cell Death & Differentiation.
[12] I. Bahar,et al. Phospholipase iPLA2β Averts Ferroptosis By Eliminating A Redox Lipid Death Signal , 2020, Nature Chemical Biology.
[13] Ming Yang,et al. SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement? , 2020, Cell death discovery.
[14] B. Stockwell,et al. Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis , 2020, Redox biology.
[15] D. Chellappan,et al. SARS CoV‐2 aggravates cellular metabolism mediated complications in COVID‐19 infection , 2020, Dermatologic therapy.
[16] S. Dodig,et al. Ferroptosis: Regulated Cell Death , 2020, Arhiv za higijenu rada i toksikologiju.
[17] Yumeng Yan,et al. The HDOCK server for integrated protein–protein docking , 2020, Nature Protocols.
[18] I. Bahar,et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death , 2020, Nature Chemical Biology.
[19] Junjian Zhang,et al. Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease , 2020, Frontiers in Neuroscience.
[20] Xiaochen Dong,et al. Recent Progress in Ferroptosis Inducers for Cancer Therapy , 2019, Advanced materials.
[21] S. Toppo,et al. Insight into the mechanism of ferroptosis inhibition by ferrostatin-1 , 2019, Redox biology.
[22] B. Brüne,et al. Regulation and Functions of 15-Lipoxygenases in Human Macrophages , 2019, Front. Pharmacol..
[23] E. Mühlberger. Faculty Opinions recommendation of Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.
[24] P. Vandenabeele,et al. The molecular machinery of regulated cell death , 2019, Cell Research.
[25] I. Bahar,et al. Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction? , 2019, Free radical biology & medicine.
[26] James Krieger,et al. Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members , 2019, J. Chem. Inf. Model..
[27] G. Rao,et al. Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies. , 2019, Progress in lipid research.
[28] I. Bahar,et al. Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE. , 2018, Journal of the American Chemical Society.
[29] Simon C Watkins,et al. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium , 2018, The Journal of clinical investigation.
[30] Torsten Schwede,et al. SWISS-MODEL: homology modelling of protein structures and complexes , 2018, Nucleic Acids Res..
[31] B. Stockwell,et al. Regulation of lipid peroxidation and ferroptosis in diverse species , 2018, Genes & development.
[32] Xiaoyuan Chen,et al. Emerging Strategies of Cancer Therapy Based on Ferroptosis , 2018, Advanced materials.
[33] Simon C Watkins,et al. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals , 2017, Cell.
[34] B. Stockwell,et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease , 2017, Cell.
[35] Jiahui Chen,et al. Improvements to the APBS biomolecular solvation software suite , 2017, Protein science : a publication of the Protein Society.
[36] E. Rosta,et al. Understanding the Molecular Mechanism of the Ala-versus-Gly Concept Controlling the Product Specificity in Reactions Catalyzed by Lipoxygenases: A Combined Molecular Dynamics and QM/MM Study of Coral 8R-Lipoxygenase , 2017 .
[37] A. Bush,et al. Ferroptosis and cell death mechanisms in Parkinson's disease , 2017, Neurochemistry International.
[38] A. Walch,et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice , 2014, Nature Cell Biology.
[39] Emad Tajkhorshid,et al. Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation , 2013, Journal of the American Chemical Society.
[40] David Ryan Koes,et al. Lessons Learned in Empirical Scoring with smina from the CSAR 2011 Benchmarking Exercise , 2013, J. Chem. Inf. Model..
[41] Shu Xu,et al. Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis. , 2012, Structure.
[42] Michael Z. Lin,et al. Improving FRET dynamic range with bright green and red fluorescent proteins , 2012, Nature Methods.
[43] K. Lorenz,et al. Raf Kinase Inhibitor Protein (RKIP) Dimer Formation Controls Its Target Switch from Raf1 to G Protein-coupled Receptor Kinase (GRK) 2* , 2012, The Journal of Biological Chemistry.
[44] Hyeon Joo,et al. OPM database and PPM web server: resources for positioning of proteins in membranes , 2011, Nucleic Acids Res..
[45] Valerie B. O’Donnell,et al. Molecular enzymology of lipoxygenases. , 2010, Archives of biochemistry and biophysics.
[46] C. Mascayano,et al. Binding of arachidonic acid and two flavonoid inhibitors to human 12- and 15-lipoxygenases: a steered molecular dynamics study , 2010, Journal of molecular modeling.
[47] Jeffery B. Klauda,et al. CHARMM-GUI Membrane Builder for mixed bilayers and its application to yeast membranes. , 2009, Biophysical journal.
[48] Sangsoo Kim,et al. Conformational flexibility in mammalian 15S‐lipoxygenase: Reinterpretation of the crystallographic data , 2008, Proteins.
[49] L. Vigh,et al. Membranes: a meeting point for lipids, proteins and therapies , 2008, Journal of cellular and molecular medicine.
[50] Yuliang Wu,et al. Detecting protein–protein interactions by far western blotting , 2007, Nature Protocols.
[51] Andrei L Lomize,et al. The role of hydrophobic interactions in positioning of peripheral proteins in membranes , 2007, BMC Structural Biology.
[52] Claus Schneider,et al. Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. , 2007, Chemistry & biology.
[53] Laxmikant V. Kalé,et al. Scalable molecular dynamics with NAMD , 2005, J. Comput. Chem..
[54] Qing Zhao,et al. Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors , 2005, Nature chemical biology.
[55] K. Lorenz,et al. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2 , 2003, Nature.
[56] I. L. Nantes,et al. Effect of Heme Iron Valence State on the Conformation of Cytochrome c and Its Association with Membrane Interfaces , 2001, The Journal of Biological Chemistry.
[57] M. Banfield,et al. Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction. , 1998, Structure.
[58] Alexander D. MacKerell,et al. All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.
[59] J. Folch,et al. A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.
[60] Simon C Watkins,et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. , 2017, Nature chemical biology.