Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs.

[1]  J. Tobias,et al.  Ferroptosis of tumour neutrophils causes immune suppression in cancer , 2022, Nature.

[2]  Junhong Lü,et al.  Membrane phosphatidylserine allosterically regulates the cytosolic phospholipase A2 activity via an electrostatic-switch mechanism. , 2022, Soft Matter.

[3]  Varnavas D. Mouchlis,et al.  Lipoprotein-associated phospholipase A2: A paradigm for allosteric regulation by membranes , 2022, Proceedings of the National Academy of Sciences.

[4]  D. Tieleman,et al.  Insights into lipid-protein interactions from computer simulations , 2021, Biophysical Reviews.

[5]  D. Girelli,et al.  Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19? , 2021, Antioxidants.

[6]  I. Bahar,et al.  NO● Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis , 2021, International journal of molecular sciences.

[7]  Ivet Bahar,et al.  ProDy 2.0: increased scale and scope after 10 years of protein dynamics modelling with Python , 2021, Bioinform..

[8]  K. Bae,et al.  Lipid Metabolism and Ferroptosis , 2021, Biology.

[9]  A. Belaidi,et al.  Ferroptosis: mechanisms and links with diseases , 2021, Signal Transduction and Targeted Therapy.

[10]  B. Stockwell,et al.  Ferroptosis: mechanisms, biology and role in disease , 2021, Nature Reviews Molecular Cell Biology.

[11]  P. Nelson,et al.  Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease , 2021, Cell Death & Differentiation.

[12]  I. Bahar,et al.  Phospholipase iPLA2β Averts Ferroptosis By Eliminating A Redox Lipid Death Signal , 2020, Nature Chemical Biology.

[13]  Ming Yang,et al.  SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement? , 2020, Cell death discovery.

[14]  B. Stockwell,et al.  Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis , 2020, Redox biology.

[15]  D. Chellappan,et al.  SARS CoV‐2 aggravates cellular metabolism mediated complications in COVID‐19 infection , 2020, Dermatologic therapy.

[16]  S. Dodig,et al.  Ferroptosis: Regulated Cell Death , 2020, Arhiv za higijenu rada i toksikologiju.

[17]  Yumeng Yan,et al.  The HDOCK server for integrated protein–protein docking , 2020, Nature Protocols.

[18]  I. Bahar,et al.  Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death , 2020, Nature Chemical Biology.

[19]  Junjian Zhang,et al.  Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease , 2020, Frontiers in Neuroscience.

[20]  Xiaochen Dong,et al.  Recent Progress in Ferroptosis Inducers for Cancer Therapy , 2019, Advanced materials.

[21]  S. Toppo,et al.  Insight into the mechanism of ferroptosis inhibition by ferrostatin-1 , 2019, Redox biology.

[22]  B. Brüne,et al.  Regulation and Functions of 15-Lipoxygenases in Human Macrophages , 2019, Front. Pharmacol..

[23]  E. Mühlberger Faculty Opinions recommendation of Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[24]  P. Vandenabeele,et al.  The molecular machinery of regulated cell death , 2019, Cell Research.

[25]  I. Bahar,et al.  Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction? , 2019, Free radical biology & medicine.

[26]  James Krieger,et al.  Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members , 2019, J. Chem. Inf. Model..

[27]  G. Rao,et al.  Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies. , 2019, Progress in lipid research.

[28]  I. Bahar,et al.  Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE. , 2018, Journal of the American Chemical Society.

[29]  Simon C Watkins,et al.  Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium , 2018, The Journal of clinical investigation.

[30]  Torsten Schwede,et al.  SWISS-MODEL: homology modelling of protein structures and complexes , 2018, Nucleic Acids Res..

[31]  B. Stockwell,et al.  Regulation of lipid peroxidation and ferroptosis in diverse species , 2018, Genes & development.

[32]  Xiaoyuan Chen,et al.  Emerging Strategies of Cancer Therapy Based on Ferroptosis , 2018, Advanced materials.

[33]  Simon C Watkins,et al.  PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals , 2017, Cell.

[34]  B. Stockwell,et al.  Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease , 2017, Cell.

[35]  Jiahui Chen,et al.  Improvements to the APBS biomolecular solvation software suite , 2017, Protein science : a publication of the Protein Society.

[36]  E. Rosta,et al.  Understanding the Molecular Mechanism of the Ala-versus-Gly Concept Controlling the Product Specificity in Reactions Catalyzed by Lipoxygenases: A Combined Molecular Dynamics and QM/MM Study of Coral 8R-Lipoxygenase , 2017 .

[37]  A. Bush,et al.  Ferroptosis and cell death mechanisms in Parkinson's disease , 2017, Neurochemistry International.

[38]  A. Walch,et al.  Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice , 2014, Nature Cell Biology.

[39]  Emad Tajkhorshid,et al.  Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation , 2013, Journal of the American Chemical Society.

[40]  David Ryan Koes,et al.  Lessons Learned in Empirical Scoring with smina from the CSAR 2011 Benchmarking Exercise , 2013, J. Chem. Inf. Model..

[41]  Shu Xu,et al.  Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis. , 2012, Structure.

[42]  Michael Z. Lin,et al.  Improving FRET dynamic range with bright green and red fluorescent proteins , 2012, Nature Methods.

[43]  K. Lorenz,et al.  Raf Kinase Inhibitor Protein (RKIP) Dimer Formation Controls Its Target Switch from Raf1 to G Protein-coupled Receptor Kinase (GRK) 2* , 2012, The Journal of Biological Chemistry.

[44]  Hyeon Joo,et al.  OPM database and PPM web server: resources for positioning of proteins in membranes , 2011, Nucleic Acids Res..

[45]  Valerie B. O’Donnell,et al.  Molecular enzymology of lipoxygenases. , 2010, Archives of biochemistry and biophysics.

[46]  C. Mascayano,et al.  Binding of arachidonic acid and two flavonoid inhibitors to human 12- and 15-lipoxygenases: a steered molecular dynamics study , 2010, Journal of molecular modeling.

[47]  Jeffery B. Klauda,et al.  CHARMM-GUI Membrane Builder for mixed bilayers and its application to yeast membranes. , 2009, Biophysical journal.

[48]  Sangsoo Kim,et al.  Conformational flexibility in mammalian 15S‐lipoxygenase: Reinterpretation of the crystallographic data , 2008, Proteins.

[49]  L. Vigh,et al.  Membranes: a meeting point for lipids, proteins and therapies , 2008, Journal of cellular and molecular medicine.

[50]  Yuliang Wu,et al.  Detecting protein–protein interactions by far western blotting , 2007, Nature Protocols.

[51]  Andrei L Lomize,et al.  The role of hydrophobic interactions in positioning of peripheral proteins in membranes , 2007, BMC Structural Biology.

[52]  Claus Schneider,et al.  Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. , 2007, Chemistry & biology.

[53]  Laxmikant V. Kalé,et al.  Scalable molecular dynamics with NAMD , 2005, J. Comput. Chem..

[54]  Qing Zhao,et al.  Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors , 2005, Nature chemical biology.

[55]  K. Lorenz,et al.  Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2 , 2003, Nature.

[56]  I. L. Nantes,et al.  Effect of Heme Iron Valence State on the Conformation of Cytochrome c and Its Association with Membrane Interfaces , 2001, The Journal of Biological Chemistry.

[57]  M. Banfield,et al.  Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction. , 1998, Structure.

[58]  Alexander D. MacKerell,et al.  All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.

[59]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.

[60]  Simon C Watkins,et al.  Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. , 2017, Nature chemical biology.