Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity.

[1]  K. Hu,et al.  Deep sequencing reveals a global reprogramming of lncRNA transcriptome during EMT. , 2017, Biochimica et biophysica acta. Molecular cell research.

[2]  R. Carstens,et al.  Alternative splicing regulates distinct subcellular localization of Epithelial splicing regulatory protein 1 (Esrp1) isoforms , 2017, Scientific Reports.

[3]  Brendan J. McConkey,et al.  The GRHL2/ZEB Feedback Loop—A Key Axis in the Regulation of EMT in Breast Cancer , 2017, Journal of cellular biochemistry.

[4]  Laising Yen,et al.  Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. , 2017, Cancer research.

[5]  N. Rajewsky,et al.  Translation of CircRNAs , 2017, Molecular cell.

[6]  N. Rajewsky,et al.  Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis , 2017, Molecular cell.

[7]  Y. Yatabe,et al.  HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition , 2017, Gut.

[8]  Edward M. Kennedy,et al.  Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk , 2017, Cell.

[9]  Peng Zhang,et al.  ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways , 2017, Molecular oncology.

[10]  Gang Li,et al.  A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity , 2017, Cell Death & Disease.

[11]  C. Ghigna,et al.  EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression , 2017, Molecular Cancer.

[12]  J. Kjems,et al.  Insights into circular RNA biology , 2017, RNA biology.

[13]  Hao Zhang,et al.  Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance , 2017, Disease markers.

[14]  F. Orso,et al.  The RNA-binding protein ESRP1 promotes human colorectal cancer progression , 2016, Oncotarget.

[15]  Jing Huang,et al.  Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β. , 2016, Molecular cell.

[16]  D. Lauffenburger,et al.  The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior , 2016, Scientific Reports.

[17]  Abigail J. Deloria,et al.  Epithelial splicing regulatory protein 1 and 2 paralogues correlate with splice signatures and favorable outcome in human colorectal cancer , 2016, Oncotarget.

[18]  B. Cieply,et al.  Ablation of the epithelial‐specific splicing factor Esrp1 results in ureteric branching defects and reduced nephron number , 2016, Developmental dynamics : an official publication of the American Association of Anatomists.

[19]  M. Rossi,et al.  miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition. , 2016, Cell reports.

[20]  B. Cieply,et al.  Multiphasic and Dynamic Changes in Alternative Splicing during Induction of Pluripotency Are Coordinated by Numerous RNA-Binding Proteins. , 2016, Cell reports.

[21]  Yan Li,et al.  Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs , 2016, Nature Communications.

[22]  Yi Xing,et al.  Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition , 2016, Molecular and Cellular Biology.

[23]  L. Niswander,et al.  Grainyhead-like 2 downstream targets act to suppress epithelial-to-mesenchymal transition during neural tube closure , 2016, Development.

[24]  E. Ben-Jacob,et al.  Stability of the hybrid epithelial/mesenchymal phenotype , 2016, Oncotarget.

[25]  C. Iacobuzio-Donahue,et al.  TGF-β Tumor Suppression through a Lethal EMT , 2016, Cell.

[26]  Archana Dhasarathy,et al.  Connecting the dots: chromatin and alternative splicing in EMT. , 2016, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[27]  Gloria M. Sheynkman,et al.  Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing , 2016, Cell.

[28]  Amy Y. M. Au,et al.  Intron retention in mRNA: No longer nonsense , 2016, BioEssays : news and reviews in molecular, cellular and developmental biology.

[29]  Simone Brabletz,et al.  A self‐enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells , 2015, International journal of cancer.

[30]  Catherine Ha Ta,et al.  An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States , 2015, PLoS Comput. Biol..

[31]  Claude C. Warzecha,et al.  The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development , 2015, eLife.

[32]  Peter R Cook,et al.  Exon Skipping Is Correlated with Exon Circularization. , 2015, Journal of molecular biology.

[33]  Brian D. Bennett,et al.  LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells , 2015, Molecular and Cellular Biology.

[34]  Petar Glažar,et al.  Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. , 2015, Molecular cell.

[35]  E. Levanon,et al.  Identification of recurrent regulated alternative splicing events across human solid tumors , 2015, Nucleic acids research.

[36]  Andreas W. Schreiber,et al.  The RNA Binding Protein Quaking Regulates Formation of circRNAs , 2015, Cell.

[37]  G. Shan,et al.  Exon-intron circular RNAs regulate transcription in the nucleus , 2015, Nature Structural &Molecular Biology.

[38]  Christoph Dieterich,et al.  Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. , 2015, Cell reports.

[39]  Robert J. Weatheritt,et al.  A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains , 2014, Cell.

[40]  Dongming Liang,et al.  Short intronic repeat sequences facilitate circular RNA production , 2014, Genes & development.

[41]  John T. Powers,et al.  The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming , 2014, Stem cell reports.

[42]  N. Rajewsky,et al.  circRNA biogenesis competes with pre-mRNA splicing. , 2014, Molecular cell.

[43]  Yi Xing,et al.  Transcriptome-wide Landscape of Pre-mRNA Alternative Splicing Associated with Metastatic Colonization , 2014, Molecular Cancer Research.

[44]  P. Sharp,et al.  Building Robust Transcriptomes with Master Splicing Factors , 2014, Cell.

[45]  Ling-Ling Chen,et al.  Complementary Sequence-Mediated Exon Circularization , 2014, Cell.

[46]  Cameron P Bracken,et al.  Genome‐wide identification of miR‐200 targets reveals a regulatory network controlling cell invasion , 2014, The EMBO journal.

[47]  M. Ares,et al.  Context-dependent control of alternative splicing by RNA-binding proteins , 2014, Nature Reviews Genetics.

[48]  M. Änkö Regulation of gene expression programmes by serine-arginine rich splicing factors. , 2014, Seminars in cell & developmental biology.

[49]  C. Bracken,et al.  MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways , 2014, Oncogene.

[50]  D. Bartel,et al.  Expanded identification and characterization of mammalian circular RNAs , 2014, Genome Biology.

[51]  C. Burge,et al.  Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state , 2014, bioRxiv.

[52]  A. Mele,et al.  Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer , 2014, eLife.

[53]  Chonghui Cheng,et al.  Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing , 2014, Genes & development.

[54]  L. Shaw,et al.  Regulated splicing of the α6 integrin cytoplasmic domain determines the fate of breast cancer stem cells. , 2014, Cell reports.

[55]  G. Christofori,et al.  The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion , 2014, Oncogene.

[56]  Samy Lamouille,et al.  Molecular mechanisms of epithelial–mesenchymal transition , 2014, Nature Reviews Molecular Cell Biology.

[57]  R. Carstens,et al.  Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion. , 2013, Developmental cell.

[58]  Gene W. Yeo,et al.  Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges , 2013, Nature Structural &Molecular Biology.

[59]  H. Ford,et al.  Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2. , 2013, Cancer research.

[60]  Richard C. McEachin,et al.  Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer , 2013, PloS one.

[61]  J. Tazi,et al.  MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation , 2013, Nature Communications.

[62]  J. Clohessy,et al.  The RNA Binding Protein ESRP1 Fine-Tunes the Expression of Pluripotency-Related Factors in Mouse Embryonic Stem Cells , 2013, PloS one.

[63]  C. Ghigna,et al.  HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition , 2013, Nucleic acids research.

[64]  Brendan J. Frey,et al.  A compendium of RNA-binding motifs for decoding gene regulation , 2013, Nature.

[65]  Eric T. Wang,et al.  MBNL proteins repress ES-cell-specific alternative splicing and reprogramming , 2013, Nature.

[66]  G. Pan,et al.  Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming , 2013, Nature Cell Biology.

[67]  L. DesGroseillers Faculty Opinions recommendation of Natural RNA circles function as efficient microRNA sponges. , 2013 .

[68]  Jia Fan,et al.  Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma , 2013, International journal of cancer.

[69]  Sebastian D. Mackowiak,et al.  Circular RNAs are a large class of animal RNAs with regulatory potency , 2013, Nature.

[70]  Jun Yao,et al.  Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas , 2013, Clinical Cancer Research.

[71]  Michael K. Slevin,et al.  Circular RNAs are abundant, conserved, and associated with ALU repeats. , 2013, RNA.

[72]  G. Berx,et al.  Regulatory networks defining EMT during cancer initiation and progression , 2013, Nature Reviews Cancer.

[73]  Hong Jiang,et al.  Grhl2 Determines the Epithelial Phenotype of Breast Cancers and Promotes Tumor Progression , 2012, PloS one.

[74]  C. Burge,et al.  Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues , 2012, Science.

[75]  F. Rousset,et al.  RBFOX2 Is an Important Regulator of Mesenchymal Tissue-Specific Splicing in both Normal and Cancer Tissues , 2012, Molecular and Cellular Biology.

[76]  R. Carstens,et al.  Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors , 2012, Proceedings of the National Academy of Sciences.

[77]  Chonghui Cheng,et al.  Snail Represses the Splicing Regulator Epithelial Splicing Regulatory Protein 1 to Promote Epithelial-Mesenchymal Transition* , 2012, The Journal of Biological Chemistry.

[78]  Eric T. Wang,et al.  Transcriptome-wide Regulation of Pre-mRNA Splicing and mRNA Localization by Muscleblind Proteins , 2012, Cell.

[79]  D. Radisky,et al.  Involvement of hnRNP A1 in the matrix metalloprotease‐3‐dependent regulation of Rac1 pre‐mRNA splicing , 2012, Journal of cellular biochemistry.

[80]  B. Cieply,et al.  Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2. , 2012, Cancer research.

[81]  R. Carstens,et al.  Genome-Wide Determination of a Broad ESRP-Regulated Posttranscriptional Network by High-Throughput Sequencing , 2012, Molecular and Cellular Biology.

[82]  Maximilian Reichert,et al.  EMT and Dissemination Precede Pancreatic Tumor Formation , 2012, Cell.

[83]  Hiroshi Tanaka,et al.  Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell , 2012, Nature Communications.

[84]  A. Menssen,et al.  miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions , 2011, Cell cycle.

[85]  K. Miyazono,et al.  TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP , 2011, Oncogene.

[86]  Christopher A. Maher,et al.  A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition , 2011, The Journal of cell biology.

[87]  Yong Jin Choi,et al.  miR-34 miRNAs provide a barrier for somatic cell reprogramming , 2011, Nature Cell Biology.

[88]  Jeffrey L. Wrana,et al.  An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming , 2011, Cell.

[89]  Nicholas C. Flytzanis,et al.  An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype , 2011, PLoS genetics.

[90]  M. F. Shannon,et al.  An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition , 2011, Molecular biology of the cell.

[91]  Chonghui Cheng,et al.  CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. , 2011, The Journal of clinical investigation.

[92]  Arun K. Ramani,et al.  Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation. , 2011, Genome research.

[93]  Yi Xing,et al.  An ESRP‐regulated splicing programme is abrogated during the epithelial–mesenchymal transition , 2010, The EMBO journal.

[94]  D. Licatalosi,et al.  Integrative Modeling Defines the Nova Splicing-Regulatory Network and Its Combinatorial Controls , 2010, Science.

[95]  Jialiang Liang,et al.  A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. , 2010, Cell stem cell.

[96]  J. Wrana,et al.  Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. , 2010, Cell stem cell.

[97]  Lior Pachter,et al.  Exon-Level Microarray Analyses Identify Alternative Splicing Programs in Breast Cancer , 2010, Molecular Cancer Research.

[98]  T. Yau,et al.  A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. , 2010, Cell stem cell.

[99]  Brendan J. Frey,et al.  Deciphering the splicing code , 2010, Nature.

[100]  Tyson A. Clark,et al.  Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy , 2010, Nature Structural &Molecular Biology.

[101]  R. Huang,et al.  Epithelial-Mesenchymal Transitions in Development and Disease , 2009, Cell.

[102]  Julia Schüler,et al.  The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs , 2009, Nature Cell Biology.

[103]  P. Jordan,et al.  Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways. , 2009, Human molecular genetics.

[104]  Claude C. Warzecha,et al.  ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. , 2009, Molecular cell.

[105]  Gene W. Yeo,et al.  An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells , 2009, Nature Structural &Molecular Biology.

[106]  D. Lauffenburger,et al.  A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. , 2008, Developmental cell.

[107]  Tyson A. Clark,et al.  HITS-CLIP yields genome-wide insights into brain alternative RNA processing , 2008, Nature.

[108]  M. F. Shannon,et al.  A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. , 2008, Cancer research.

[109]  Chad A. Cowan,et al.  A high-efficiency system for the generation and study of human induced pluripotent stem cells. , 2008, Cell stem cell.

[110]  M. Garcia-Blanco,et al.  hnRNP H and hnRNP F Complex with Fox2 To Silence Fibroblast Growth Factor Receptor 2 Exon IIIc , 2008, Molecular and Cellular Biology.

[111]  Wenjun Guo,et al.  The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.

[112]  T. Brabletz,et al.  A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells , 2008, EMBO reports.

[113]  G. Goodall,et al.  The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 , 2008, Nature Cell Biology.

[114]  H. Christofk,et al.  Pyruvate kinase M2 is a phosphotyrosine-binding protein , 2008, Nature.

[115]  Wei Guo,et al.  Exo70 interacts with the Arp2/3 complex and regulates cell migration , 2006, Nature Cell Biology.

[116]  M. Dewhirst,et al.  Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity , 2006, Proceedings of the National Academy of Sciences.

[117]  Michael R Green,et al.  Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. , 2005, Molecular cell.

[118]  D. Albertson,et al.  Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability , 2005, Nature.

[119]  B. Spencer‐Dene,et al.  An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. , 2000, Development.

[120]  J. Thiery,et al.  Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells. , 1994, Molecular biology of the cell.

[121]  Peter Goodfellow,et al.  Circular transcripts of the testis-determining gene Sry in adult mouse testis , 1993, Cell.

[122]  P. Span,et al.  Roles and Regulation of Epithelial Splicing Regulatory Proteins 1 and 2 in Epithelial-Mesenchymal Transition. , 2016, International review of cell and molecular biology.

[123]  Lei Liu,et al.  Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. , 2016, Cancer biomarkers : section A of Disease markers.

[124]  B. Cieply,et al.  Genome-wide activities of RNA binding proteins that regulate cellular changes in the epithelial to mesenchymal transition (EMT). , 2014, Advances in experimental medicine and biology.

[125]  L. Shkreta,et al.  hnRNP proteins and splicing control. , 2007, Advances in experimental medicine and biology.