Hormone Signaling

[1]  Zhuowei Wang,et al.  Modulation of Circulating Leptin Levels by Its Soluble Receptor* , 2001, The Journal of Biological Chemistry.

[2]  R. Kapur,et al.  A Novel Mechanism of Cooperation between c-Kit and Erythropoietin Receptor , 2001, The Journal of Biological Chemistry.

[3]  美仁 長谷山 Phosphatidylinositol 3-Kinase Is Involved in the Protection of Primary Cultured Human Erythroid Precursor Cells From Apoptosis , 2001 .

[4]  J. Flier,et al.  SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985 * , 2000, The Journal of Biological Chemistry.

[5]  A. Gewirtz,et al.  PI-3k-Akt axis inhibits apoptosis in normal human megakaryoblasts and is efficiently activated by thrombopoietin , 2000 .

[6]  A. Miyajima,et al.  Thrombopoietin and interleukin-2 induce association of CRK with STAT5. , 2000, Biochemical and biophysical research communications.

[7]  H. Sakamoto,et al.  Mitogen-activated Protein Kinase Plays an Essential Role in the Erythropoietin-dependent Proliferation of CTLL-2 Cells* , 2000, The Journal of Biological Chemistry.

[8]  G. Fantuzzi,et al.  Leptin in the regulation of immunity, inflammation, and hematopoiesis , 2000, Journal of leukocyte biology.

[9]  A. Yoshimura,et al.  CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2* , 2000, The Journal of Biological Chemistry.

[10]  Y. Miyakawa,et al.  Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1. , 2000, Blood.

[11]  L. Platanias,et al.  Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors. , 2000, Biochemical and biophysical research communications.

[12]  J. Ryan,et al.  JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells. , 2000, Blood.

[13]  M. Karin,et al.  Requirement for p38α in Erythropoietin Expression A Role for Stress Kinases in Erythropoiesis , 2000, Cell.

[14]  J. Schwartz,et al.  The role of STAT proteins in growth hormone signaling , 2000, Oncogene.

[15]  Alexander S. Banks,et al.  Activation of Downstream Signals by the Long Form of the Leptin Receptor* , 2000, The Journal of Biological Chemistry.

[16]  Christopher E. Rudd,et al.  Lymphocyte signaling: Cbl sets the threshold for autoimmunity , 2000, Current Biology.

[17]  F. Porteu,et al.  A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts , 2000, Oncogene.

[18]  S. Klinken,et al.  HS1 Interacts with Lyn and Is Critical for Erythropoietin-induced Differentiation of Erythroid Cells* , 2000, The Journal of Biological Chemistry.

[19]  M. Ballmaier,et al.  Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets. , 2000, Experimental hematology.

[20]  J. van der Kaay,et al.  Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line* , 2000, The Journal of Biological Chemistry.

[21]  B. Beattie,et al.  The SH2 Inositol 5-Phosphatase Ship1 Is Recruited in an SH2-dependent Manner to the Erythropoietin Receptor* , 2000, The Journal of Biological Chemistry.

[22]  J. Myklebust,et al.  Protein kinase C-α isoform is involved in erythropoietin-induced erythroid differentiation of CD34+ progenitor cells from human bone marrow , 2000 .

[23]  F. D. de Sauvage,et al.  Role of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo , 2000, Molecular and Cellular Biology.

[24]  C. Carter-Su,et al.  SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone. , 2000, Recent progress in hormone research.

[25]  J. Herrington,et al.  Role of the tyrosine kinase JAK2 in signal transduction by growth hormone , 2000, Pediatric Nephrology.

[26]  R. Jaster,et al.  Activation of STAT5 during EPO-directed suppression of apoptosis. , 2000, Cellular signalling.

[27]  B. Druker,et al.  Thrombopoietin-Induced Signal Transduction and Potentiation of Platelet Activation , 1999, Thrombosis and Haemostasis.

[28]  B. Haye,et al.  Erythropoietin Induces Glycosylphosphatidylinositol Hydrolysis , 1999, The Journal of Biological Chemistry.

[29]  S. Gammeltoft,et al.  Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2 , 1999, Molecular and Cellular Endocrinology.

[30]  S. R. Datta,et al.  Cellular survival: a play in three Akts. , 1999, Genes & development.

[31]  N. Miyasaka,et al.  CrkL Mediates Ras-dependent Activation of the Raf/ERK Pathway through the Guanine Nucleotide Exchange Factor C3G in Hematopoietic Cells Stimulated with Erythropoietin or Interleukin-3* , 1999, The Journal of Biological Chemistry.

[32]  J. Flier,et al.  The Role of SOCS-3 in Leptin Signaling and Leptin Resistance* , 1999, The Journal of Biological Chemistry.

[33]  A. Yoshimura,et al.  Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. , 1999, Experimental hematology.

[34]  Paul J Hertzog,et al.  SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine , 1999, Cell.

[35]  M. Kubo,et al.  Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice , 1999, Molecular and Cellular Biology.

[36]  Arun Sharma,et al.  Engagement of Gab1 and Gab2 in Erythropoietin Signaling* , 1999, The Journal of Biological Chemistry.

[37]  K. Kaushansky,et al.  Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. , 1999, Blood.

[38]  H. Lodish,et al.  Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice A Direct Role for Stat5 in Bcl-XL Induction , 1999, Cell.

[39]  T. Uchiyama,et al.  Thrombopoietin potentiates agonist-stimulated activation of p38 mitogen-activated protein kinase in human platelets. , 1999, Biochemical and biophysical research communications.

[40]  K. Kaushansky,et al.  Thrombopoietin Signal Transduction Requires Functional JAK2, Not TYK2* , 1999, The Journal of Biological Chemistry.

[41]  A. Yoshimura,et al.  APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl , 1999, Leukemia.

[42]  C. Lacombe,et al.  Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and phosphatidylinositol 3-kinase. , 1999, Blood.

[43]  K. Kaushansky Thrombopoietin and Hematopoietic Stem Cell Development , 1999, Annals of the New York Academy of Sciences.

[44]  R. Jove,et al.  Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines. , 1999, Blood.

[45]  M. Eguchi,et al.  Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[46]  K. Kaushansky,et al.  Thrombopoietin signal transduction: studies from cell lines and primary cells. , 1999, Methods.

[47]  A. Yoshimura,et al.  The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop , 1999, The EMBO journal.

[48]  A. Miyajima,et al.  Role of cytokine signaling molecules in erythroid differentiation of mouse fetal liver hematopoietic cells: functional analysis of signaling molecules by retrovirus-mediated expression. , 1999, Blood.

[49]  I. Wilson,et al.  Erythropoietin receptor activation by a ligand-induced conformation change. , 1999, Science.

[50]  F. D. de Sauvage,et al.  Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[51]  R. Jaster,et al.  SHP1 Protein Tyrosine Phosphatase Negatively Modulates Erythroid Differentiation and Suppression of Apoptosis in J2E Erythroleukemic Cells , 1999, Biological chemistry.

[52]  Stefan N. Constantinescu,et al.  The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction , 1999, Trends in Endocrinology & Metabolism.

[53]  F. Porteu,et al.  Megakaryocyte growth and development factor-induced proliferation and differentiation are regulated by the mitogen-activated protein kinase pathway in primitive cord blood hematopoietic progenitors. , 1999, Blood.

[54]  P. Mayeux,et al.  Physical and Functional Interaction between p72 syk and Erythropoietin Receptor* , 1998, The Journal of Biological Chemistry.

[55]  T. Uchiyama,et al.  Thrombopoietin potentiates the protein-kinase-C-mediated activation of mitogen-activated protein kinase/ERK kinases and extracellular signal-regulated kinases in human platelets. , 1998, European journal of biochemistry.

[56]  J. Ihle,et al.  Signaling by the Cytokine Receptor Superfamily a , 1998, Annals of the New York Academy of Sciences.

[57]  A. Yoshimura,et al.  The CIS family: negative regulators of JAK-STAT signaling. , 1998, Cytokine & growth factor reviews.

[58]  S. Feller,et al.  Physiological signals and oncogenesis mediated through Crk family adapter proteins , 1998, Journal of cellular physiology.

[59]  S. Shimamura,et al.  Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin. , 1998, Biochemical and biophysical research communications.

[60]  A. Yoshimura,et al.  Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation , 1998, The Journal of Biological Chemistry.

[61]  F. Gouilleux,et al.  A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B , 1998, Molecular and Cellular Biology.

[62]  Y Nagata,et al.  Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation. , 1998, Blood.

[63]  R. Gregory,et al.  Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization. , 1998, Blood.

[64]  J. Krosl,et al.  The hyperresponsiveness of cells expressing truncated erythropoietin receptors is contingent on insulin-like growth factor-1 in fetal calf serum. , 1998, Blood.

[65]  M. Souyri Mpl: from an acute myeloproliferative virus to the isolation of the long sought thrombopoietin. , 1998, Seminars in hematology.

[66]  T. Hirano,et al.  Involvement of Prolonged Ras Activation in Thrombopoietin-Induced Megakaryocytic Differentiation of a Human Factor-Dependent Hematopoietic Cell Line , 1998, Molecular and Cellular Biology.

[67]  P. Kelly,et al.  Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. , 1998, Endocrine reviews.

[68]  G. Krystal,et al.  Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. , 1998, Genes & development.

[69]  Michael P. Brown,et al.  Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.

[70]  N. Stahl,et al.  Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[71]  N. Miyasaka,et al.  Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. , 1998, Blood.

[72]  A. Yoshimura,et al.  Physiology and function of the erythropoietin receptor , 1998, Current opinion in hematology.

[73]  A. Cumano,et al.  Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis , 1998, Cell.

[74]  J. Marine,et al.  Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors , 1998, Cell.

[75]  J. Flier,et al.  Identification of SOCS-3 as a potential mediator of central leptin resistance. , 1998, Molecular cell.

[76]  W. Vainchenker,et al.  Protein kinase C mediates the mitogenic action of thrombopoietin in c-Mpl-expressing UT-7 cells , 1998 .

[77]  H. Lodish,et al.  Tyrosine Residues within the Intracellular Domain of the Erythropoietin Receptor Mediate Activation of AP-1 Transcription Factors* , 1998, The Journal of Biological Chemistry.

[78]  H. Lodish,et al.  The prolactin receptor rescues EpoR-/- erythroid progenitors and replaces EpoR in a synergistic interaction with c-kit. , 1998, Blood.

[79]  B. Druker,et al.  Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors. , 1998, Blood.

[80]  Y. Oka,et al.  Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase. , 1997, Biochemical and biophysical research communications.

[81]  J. Flier,et al.  Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor* , 1997, The Journal of Biological Chemistry.

[82]  S. Goff,et al.  The Thrombopoietin Receptor Can Mediate Proliferation without Activation of the Jak-STAT Pathway , 1997, The Journal of experimental medicine.

[83]  U Klingmüller,et al.  The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells--signals emanating from the erythropoietin receptor. , 1997, European journal of biochemistry.

[84]  C. Lacombe,et al.  Erythropoietin Induces the Tyrosine Phosphorylation of Insulin Receptor Substrate-2 , 1997, The Journal of Biological Chemistry.

[85]  I. Dusanter-Fourt,et al.  The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). , 1997, European journal of biochemistry.

[86]  I. Dusanter-Fourt,et al.  Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway , 1997, Molecular and cellular biology.

[87]  B. Schwartz,et al.  Protein kinase C in erythroid and megakaryocytic differentiation: possible role in lineage determination. , 1997, Biochimica et biophysica acta.

[88]  E. Nishida,et al.  Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3. , 1997, Blood.

[89]  L. Tartaglia,et al.  Leptin Receptor Action in Hepatic Cells* , 1997, The Journal of Biological Chemistry.

[90]  H. Iwasaki,et al.  Role of the vav Proto-oncogene Product (Vav) in Erythropoietin-mediated Cell Proliferation and Phosphatidylinositol 3-Kinase Activity* , 1997, The Journal of Biological Chemistry.

[91]  H. Lodish,et al.  The Prolactin Receptor and Severely Truncated Erythropoietin Receptors Support Differentiation of Erythroid Progenitors* , 1997, The Journal of Biological Chemistry.

[92]  K. Chihara,et al.  Leptin Induces Mitogen-activated Protein Kinase- dependent Proliferation of C3H10T1/2 Cells* , 1997, The Journal of Biological Chemistry.

[93]  L. Yu-Lee Molecular Actions of Prolactin in the Immune System , 1997, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[94]  Y. Matsuzawa,et al.  Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5 , 1997, Molecular and cellular biology.

[95]  A. Yoshimura,et al.  CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. , 1997, Blood.

[96]  B. Druker,et al.  Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins. , 1997, Blood.

[97]  E. Nishida,et al.  Activation of JNK signaling pathway by erythropoietin, thrombopoietin, and interleukin-3. , 1997, Blood.

[98]  R. Salgia,et al.  Thrombopoietin induces activation of the phosphatidylinositol‐3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL , 1997, Journal of cellular physiology.

[99]  S. Klinken,et al.  Lyn tyrosine kinase is essential for erythropoietin‐induced differentiation of J2E erythroid cells , 1997, The EMBO journal.

[100]  H. Lodish,et al.  Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[101]  R. Skoda,et al.  The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. , 1997, Molecular endocrinology.

[102]  A. Yoshimura,et al.  STAT5 Activation Correlates with Erythropoietin Receptor-mediated Erythroid Differentiation of an Erythroleukemia Cell Line* , 1997, The Journal of Biological Chemistry.

[103]  K. Kaushansky,et al.  Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[104]  L. Tartaglia,et al.  The Leptin Receptor* , 1997, The Journal of Biological Chemistry.

[105]  H. Lodish,et al.  Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[106]  Y. Yamashita,et al.  Tec protein-tyrosine kinase is involved in the thrombopoietin/c-Mpl signaling pathway. , 1997, Experimental hematology.

[107]  T. Hirano,et al.  An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT , 1997, Oncogene.

[108]  N. Komatsu,et al.  Protein kinase C and c-myc gene activation pathways in thrombopoietin signal transduction. , 1997, Biochemical and biophysical research communications.

[109]  K. Xia,et al.  Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells. , 1997, Blood.

[110]  N. Ben-Jonathan,et al.  Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects. , 1996, Endocrine reviews.

[111]  W. Alexander,et al.  Tyrosine‐599 of the c‐Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation. , 1996, The EMBO journal.

[112]  P. Dentelli,et al.  Discrete protein interactions with the Grb2/c-Cbl complex in SCF- and TPO-mediated myeloid cell proliferation. , 1996, Oncogene.

[113]  M. Phillips,et al.  Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells. , 1996, Endocrinology.

[114]  A. Sytkowski,et al.  Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation. , 1996, The Journal of biological chemistry.

[115]  M. Gishizky,et al.  Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adaptor protein. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[116]  J. Darnell,et al.  Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice , 1996, Nature Genetics.

[117]  B. Druker,et al.  p120c-cbl is present in human blood platelets and is differentially involved in signaling by thrombopoietin and thrombin. , 1996, Blood.

[118]  L. Tartaglia,et al.  The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[119]  F. Verdier,et al.  Erythropoietin‐induced erythroid differentiation of the human erythroleukemia cell line TF‐1 correlates with impaired STAT5 activation. , 1996, The EMBO journal.

[120]  T. He,et al.  The box1 Domain of the Erythropoietin Receptor Specifies Janus Kinase 2 Activation and Functions Mitogenically within an Interleukin 2 β-Receptor Chimera* , 1996, The Journal of Biological Chemistry.

[121]  R. Skoda,et al.  Defective STAT signaling by the leptin receptor in diabetic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[122]  H. Broxmeyer,et al.  Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis. , 1996, Blood.

[123]  B. Groner,et al.  Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. , 1996, The EMBO journal.

[124]  I. Dusanter-Fourt,et al.  Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin , 1996, Molecular and cellular biology.

[125]  P. Majerus,et al.  The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[126]  J. Friedman,et al.  Abnormal splicing of the leptin receptor in diabetic mice , 1996, Nature.

[127]  L. Tartaglia,et al.  Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice , 1996, Cell.

[128]  V. D’Agati,et al.  Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. , 1996, Genes & development.

[129]  B. Druker,et al.  Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets. , 1996, Blood.

[130]  Y. Yazaki,et al.  Proto-oncogene products Vav and c-Cbl are involved in the signal transduction through Grb2/Ash in hematopoietic cells. , 1996, Acta haematologica.

[131]  C. Marshall,et al.  Control of the ERK MAP kinase cascade by Ras and Raf. , 1996, Cancer surveys.

[132]  E. Melloni,et al.  Correlation between levels of delta protein kinase C and resistance to differentiation in murine erythroleukemia cells. , 1996, Biochemical and biophysical research communications.

[133]  Rene Devos,et al.  Identification and expression cloning of a leptin receptor, OB-R , 1995, Cell.

[134]  Y. Yazaki,et al.  TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules. , 1995, Biochemical and biophysical research communications.

[135]  W. Alexander,et al.  Point mutations within a dimer interface homology domain of c‐Mpl induce constitutive receptor activity and tumorigenicity. , 1995, The EMBO journal.

[136]  J. Krosl,et al.  Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation. , 1995, The EMBO journal.

[137]  Thomas Madej,et al.  Threading analysis suggests that the obese gene product may be a helical cytokine , 1995, FEBS letters.

[138]  H. Lodish,et al.  Interaction of the erythropoietin and stem-cell-factor receptors , 1995, Nature.

[139]  H. Mano,et al.  Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. , 1995, Oncogene.

[140]  R. Salgia,et al.  The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. , 1995, Experimental hematology.

[141]  A. Gurney,et al.  Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[142]  D. Levy,et al.  Thrombopoietin activates a STAT5‐like factor in hematopoietic cells. , 1995, The EMBO journal.

[143]  N. Copeland,et al.  A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors. , 1995, The EMBO journal.

[144]  T. He,et al.  Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway , 1995, The Journal of Biological Chemistry.

[145]  J. Griffin,et al.  The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl (*) , 1995, The Journal of Biological Chemistry.

[146]  H. Broxmeyer,et al.  Involvement of SH2-containing Phosphotyrosine Phosphatase Syp in Erythropoietin Receptor Signal Transduction Pathways (*) , 1995, The Journal of Biological Chemistry.

[147]  Ursula Klingmüller,et al.  Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals , 1995, Cell.

[148]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.

[149]  B. Druker,et al.  Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets. , 1995, Blood.

[150]  N. Aoki,et al.  Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. , 1994, The Journal of biological chemistry.

[151]  K. Siminovitch,et al.  Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function. , 1994, Clinical immunology and immunopathology.

[152]  L. Yu-Lee,et al.  Transcriptional regulation by the helix bundle peptide hormones: growth hormone, prolactin, and hematopoietic cytokines. , 1994, Endocrine reviews.

[153]  G. Krystal,et al.  Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc , 1994, Molecular and cellular biology.

[154]  N. Komatsu,et al.  Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line. , 1994, The Journal of biological chemistry.

[155]  H. Lodish,et al.  Activation and inhibition of erythropoietin receptor function: role of receptor dimerization , 1994, Molecular and cellular biology.

[156]  E. Melloni,et al.  Protein kinase C isoforms in murine erythroleukemia cells and their involvement in the differentiation process , 1994, FEBS letters.

[157]  N. Aoki,et al.  Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor. , 1994, The Journal of biological chemistry.

[158]  O. Silvennoinen,et al.  JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin , 1993, Cell.

[159]  P. Leder,et al.  Murine c‐mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. , 1993, The EMBO journal.

[160]  Y. Yazaki,et al.  Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells. , 1993, Blood.

[161]  J. Cleveland,et al.  Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors , 1993, Molecular and cellular biology.

[162]  J. Mornon,et al.  Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[163]  N. Casadevall,et al.  Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells. , 1992, The Journal of biological chemistry.

[164]  H. Lodish,et al.  Homodimerization and constitutive activation of the erythropoietin receptor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[165]  J. Ihle,et al.  Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis , 1991, Molecular and cellular biology.

[166]  F. Wendling,et al.  A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors , 1990, Cell.

[167]  A. D’Andrea,et al.  Human erythropoietin receptor: cloning, expression, and biologic characterization. , 1990, Blood.

[168]  H. Lodish,et al.  Expression cloning of the murine erythropoietin receptor , 1989, Cell.

[169]  K P Hummel,et al.  Diabetes, a New Mutafton in the Mouse , 1966, Science.

[170]  M. Dickie,et al.  Obese, a new mutation in the house mouse. , 1950, The Journal of heredity.