Formulation development and evaluation of floating wax microspheres of Tizanidine hydrochloride

Development in the field of novel drug delivery is getting more attention, but still the oral route of administration is the most preferred route of administration as the physiology of the gastrointestinal tract offer more opportunities for the development of the dosage form. Thus the focus of the researcher is on the study of extended release of the drug with well controlled release profile (Dubey et al., 2013). Retention of the dosage form in the gastric fluid increases the gastric transit time which ultimately increases the bioavailability of poorly soluble drugs (Patel et al., 2011). These systems are suitable for the drugs that are absorbed from the stomach (Rao et al., 2016).