A novel derivative of riccardin D induces cell death through lysosomal rupture in vitro and inhibits tumor growth in vivo.

[1]  H. Lou,et al.  Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents. , 2012, Bioorganic & medicinal chemistry.

[2]  J. Mindell Lysosomal acidification mechanisms. , 2012, Annual review of physiology.

[3]  Zu-hua Gao,et al.  Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II , 2012, Investigational New Drugs.

[4]  G. Peters,et al.  Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance , 2011, Clinical Cancer Research.

[5]  Xian-Jun Qu,et al.  Inhibition of angiogenesis involves in anticancer activity of riccardin D, a macrocyclic bisbibenzyl, in human lung carcinoma. , 2011, European journal of pharmacology.

[6]  Abena B. Redwood,et al.  A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair , 2011, The EMBO journal.

[7]  P. Tripal,et al.  Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system , 2010, Journal of cellular physiology.

[8]  H. Xin,et al.  3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines. , 2010, Biochemical and biophysical research communications.

[9]  K. Sandhoff,et al.  Lysosomal degradation of membrane lipids , 2010, FEBS letters.

[10]  Chia-Nan Chen,et al.  Marchantin A, a cyclic bis(bibenzyl ether), isolated from the liverwort Marchantia emarginata subsp. tosana induces apoptosis in human MCF-7 breast cancer cells. , 2010, Cancer letters.

[11]  P. K. Sobhan,et al.  Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin‐induced apoptosis , 2010, Molecular carcinogenesis.

[12]  Na Zhang,et al.  RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis , 2009, Science.

[13]  V. Turk,et al.  Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?* , 2009, The Journal of Biological Chemistry.

[14]  C. Watson,et al.  The Role of Cathepsins in Involution and Breast Cancer , 2009, Journal of Mammary Gland Biology and Neoplasia.

[15]  M. Jäättelä,et al.  Lysosomal involvement in cell death and cancer. , 2009, Biochimica et biophysica acta.

[16]  G. Kroemer,et al.  Lysosomal membrane permeabilization in cell death , 2008, Oncogene.

[17]  G. Salvesen,et al.  Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues* , 2008, Journal of Biological Chemistry.

[18]  Xian-Jun Qu,et al.  Marchantin C, a macrocyclic bisbibenzyl, induces apoptosis of human glioma A172 cells. , 2008, Cancer letters.

[19]  M. Chiong,et al.  Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells. , 2008, Free radical biology & medicine.

[20]  C. Peters,et al.  Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation , 2008, The Journal of experimental medicine.

[21]  T. Hupp,et al.  Identification of a Dominant Negative Functional Domain on DAPK-1 That Degrades DAPK-1 Protein and Stimulates TNFR-1-mediated Apoptosis* , 2007, Journal of Biological Chemistry.

[22]  Guido Kroemer,et al.  Caspase-independent cell death , 2005, Nature Medicine.

[23]  D. Hanahan,et al.  Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. , 2004, Cancer cell.

[24]  G. Melino,et al.  Regulation of the apoptosis–necrosis switch , 2004, Oncogene.

[25]  R. Myers,et al.  Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins* , 2004, Journal of Biological Chemistry.

[26]  G. Giaccone,et al.  Cathepsin B Mediates Caspase-Independent Cell Death Induced by Microtubule Stabilizing Agents in Non-Small Cell Lung Cancer Cells , 2004, Cancer Research.

[27]  C. Isidoro,et al.  Destination ‘Lysosome’: a target organelle for tumour cell killing? , 2003, Journal of molecular recognition : JMR.

[28]  Jiahuai Han,et al.  Susceptibility of Lysosomes to Rupture Is a Determinant for Plasma Membrane Disruption in Tumor Necrosis Factor Alpha-Induced Cell Death , 2003, Molecular and Cellular Biology.

[29]  G. Kroemer,et al.  Organelle-specific initiation of cell death pathways , 2001, Nature Cell Biology.

[30]  G. Poirier,et al.  Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases , 2001, Cell Death and Differentiation.

[31]  M. Leist,et al.  Triggering of apoptosis by cathepsins , 2001, Cell Death and Differentiation.

[32]  Y. Tohyama,et al.  Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39. , 2001, Cancer research.

[33]  Y. Tsujimoto,et al.  Intracellular ATP levels determine cell death fate by apoptosis or necrosis. , 1997, Cancer research.

[34]  A. Cuervo,et al.  A Population of Rat Liver Lysosomes Responsible for the Selective Uptake and Degradation of Cytosolic Proteins* , 1997, The Journal of Biological Chemistry.

[35]  R. Firestone,et al.  Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents. , 1979, Journal of medicinal chemistry.

[36]  R. Wattiaux,et al.  Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient , 1978, The Journal of cell biology.

[37]  G. Robert,et al.  Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR–ABL cleavage and elimination of chronic myelogenous leukemia cells , 2010, Leukemia.