Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

[1]  Sridhar Ramaswamy,et al.  Dynamic Chromatin Modification Sustains Epithelial-Mesenchymal Transition following Inducible Expression of Snail-1 , 2013, Cell reports.

[2]  H. Howe,et al.  Pathology and classification of ovarian tumors , 2003, Cancer.

[3]  E. Lander,et al.  Identification of a selective small molecule inhibitor of breast cancer stem cells. , 2012, Bioorganic & medicinal chemistry letters.

[4]  G. Superti-Furga,et al.  Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death , 2015, ACS chemical biology.

[5]  L. Chung,et al.  Snail transcription factor regulates neuroendocrine differentiation in LNCaP prostate cancer cells , 2010, The Prostate.

[6]  Ben S. Wittner,et al.  Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 , 2009, Nature.

[7]  Joshua A. Bittker,et al.  Correlating chemical sensitivity and basal gene expression reveals mechanism of action , 2015, Nature chemical biology.

[8]  G. Freeman,et al.  Learning from PD-1 Resistance: New Combination Strategies. , 2016, Trends in molecular medicine.

[9]  J. Wolff,et al.  How long can folinic acid rescue be delayed after high‐dose methotrexate without toxicity? , 2014, Pediatric blood & cancer.

[10]  Jianguo Song EMT or apoptosis: a decision for TGF-β , 2007, Cell Research.

[11]  Sourav Bandyopadhyay,et al.  Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation. , 2014, Cancer discovery.

[12]  Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma , 2015, Genome Biology.

[13]  B. Carlson,et al.  Inhibition of selenoprotein synthesis by selenocysteine tRNA[Ser]Sec lacking isopentenyladenosine. , 2000, The Journal of biological chemistry.

[14]  Michael Peyton,et al.  An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance , 2012, Clinical Cancer Research.

[15]  Alexander Feuerborn,et al.  Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism , 2015, EMBO reports.

[16]  R. Guigó,et al.  Characterization of Mammalian Selenoproteomes , 2003, Science.

[17]  R. Dummer,et al.  In vivo switching of human melanoma cells between proliferative and invasive states. , 2008, Cancer research.

[18]  Katherine R. Singleton,et al.  A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop , 2013, Oncogenesis.

[19]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[20]  Nicole E. Bodycombe,et al.  Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses , 2014, Journal of biomolecular screening.

[21]  Klemens Vierlinger,et al.  Meta-Analysis of Gene Expression Signatures Defining the Epithelial to Mesenchymal Transition during Cancer Progression , 2012, PloS one.

[22]  P. Sorger,et al.  Systems biology and combination therapy in the quest for clinical efficacy , 2006, Nature chemical biology.

[23]  Kakajan Komurov,et al.  Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes , 2010, Proceedings of the National Academy of Sciences.

[24]  Matthew E. Welsch,et al.  Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.

[25]  Sydney M. Shaffer,et al.  Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance , 2017, Nature.

[26]  Hans Clevers,et al.  Organoid Cultures Derived from Patients with Advanced Prostate Cancer , 2014, Cell.

[27]  Neville E. Sanjana,et al.  Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.

[28]  J. Keith Joung,et al.  Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo , 2014, Nature Biotechnology.

[29]  Mala Sinha,et al.  Pathway Signature and Cellular Differentiation in Clear Cell Renal Cell Carcinoma , 2010, PloS one.

[30]  Charles H. Yoon,et al.  Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq , 2016, Science.

[31]  Li Ma,et al.  ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance , 2015, Cell cycle.

[32]  Petra C. Schwalie,et al.  Identification of the transcription factor ZEB 1 as a central component of 1 the adipogenic gene regulatory network 2 3 , 2022 .

[33]  Chris Albanese,et al.  ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. , 2012, The American journal of pathology.

[34]  Joshua A. Bittker,et al.  Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. , 2015, Cancer discovery.