Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia

[1]  S. Miyano,et al.  Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia , 2015, PloS one.

[2]  A. Baruchel,et al.  Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network , 2015, Nature Genetics.

[3]  Chibo Hong,et al.  DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors. , 2015, Cancer cell.

[4]  T. Golub,et al.  The Genomic Landscape of Juvenile Myelomonocytic Leukemia , 2015, Nature Genetics.

[5]  M. Loh,et al.  Phase II/III trial of a pre‐transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: A report from the Children's Oncology Group , 2015, Pediatric blood & cancer.

[6]  Doron Betel,et al.  Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution , 2015, Journal of visualized experiments : JoVE.

[7]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[8]  John R. Haliburton,et al.  Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia. , 2015, Blood.

[9]  R. Eils,et al.  Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing , 2014 .

[10]  R. Eils,et al.  Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. , 2014, Cell stem cell.

[11]  Rafael A. Irizarry,et al.  Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays , 2014, Bioinform..

[12]  M. Loh,et al.  Juvenile Myelomonocytic Leukemia: Molecular Pathogenesis Informs Current Approaches to Therapy and Hematopoietic Cell Transplantation , 2014, Front. Pediatr..

[13]  G. Kronnie,et al.  Different outcomes of allogeneic hematopoietic stem cell transplant in a pair of twins affected by juvenile myelomonocytic leukemia , 2014, International Journal of Hematology.

[14]  S. Miyano,et al.  Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia , 2013, Nature Genetics.

[15]  Pau Farré,et al.  Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array , 2013, Epigenetics & Chromatin.

[16]  G. Satten,et al.  Age-associated DNA methylation in pediatric populations. , 2012, Genome research.

[17]  Colin N. Dewey,et al.  RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome , 2011, BMC Bioinformatics.

[18]  C. Plass,et al.  Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome. , 2011, Blood.

[19]  Felix Krueger,et al.  Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications , 2011, Bioinform..

[20]  Cole Trapnell,et al.  Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. , 2010, Nature biotechnology.

[21]  Fabien Campagne,et al.  DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. , 2010, Cancer cell.

[22]  R. Jaenisch,et al.  DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction , 2009, Nature Genetics.

[23]  M. Loh,et al.  Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. , 2009, Blood.

[24]  I. Weissman,et al.  In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood , 2008, Nature Protocols.

[25]  K. Koike,et al.  Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. , 2007, Blood.

[26]  E. Lanino,et al.  Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. , 2005, Blood.

[27]  Wilcox Wd Occurrence of myeloproliferative disorder in patients with Noonan syndrome. , 1998 .