PREPARATION AND APPLICATION OF MIXED OCTADECYLSILYL- AND (3-(C-METHYLCALIX[4]RESORCINARENE)-HYDROXYPROPOXY)-PROPYLSILYL–APPENDED SILICA PARTICLES AS STATIONARY PHASE FOR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

A new type of mixed octadecylsily (ODS)- and (3-(C-methylcalix[4]resorcinarene)-2-hydroxypropoxy)-propylsilyl–appended silica particles (ODS-MCR-HPS) have been prepared and used as stationary phase for high-performance liquid chromatography (HPLC) for the first time. Elemental analysis and Fourier-transform infrared spectroscopy have been applied to characterize the synthetic ODS-MCR-HPS. The new stationary phase contains two types of interaction sites for separation: ODS and MCR. The chromatographic performance of ODS-MCR-HPS was investigated by separating several disubstituted benzenes and some aromatic hydocarbons under both reversed-phase and normal-phase conditions. The results show that ODS-MCR-HPS exhibits excellent selectivity for the separation of positional isomers of disubstituted benzenes and mixtures of some aromatic hydrocarbon compounds due to the cooperative and complementary functioning of the ODS and MCR under different mobile phase conditions.

[1]  E. Yong,et al.  Preparation and application of methylcalix[4]resorcinarene-bonded silica particles as chiral stationary phase in high-performance liquid chromatography. , 2011, Chirality.

[2]  M. Yılmaz,et al.  Preparation of a new 1,3-alternate-calix[4]arene-bonded HPLC stationary phase for the separation of phenols, aromatic amines and drugs. , 2010, Talanta.

[3]  N. Scully,et al.  Polar-Embedded and Polar-Endcapped Stationary Phases for LC , 2010 .

[4]  M. Hyun,et al.  Enantioseparation of alpha-amino acids on an 18-crown-6-tetracarboxylic acid-bonded silica by capillary electrochromatography. , 2010, Journal of chromatography. A.

[5]  E. Yong,et al.  Application of bromoacetate-substituted beta-CD-bonded silica particles as chiral stationary phase for HPLC. , 2010, Journal of separation science.

[6]  B. Ye,et al.  Preparation and Characterization of p-tert-Butylcalix[4]arene Modified Sol-Gel Column for Open-Tubular Capillary Electrochromatography , 2009 .

[7]  S. Ng,et al.  Synthesis and application of mono-6-(3-methylimidazolium)-6-deoxyperphenylcarbamoyl-beta-cyclodextrin chloride as chiral stationary phases for high-performance liquid chromatography and supercritical fluid chromatography. , 2008, Journal of chromatography. A.

[8]  Rudiger Meyer and Thomas Jira.  Calixarene HPLC Phases - Applications , 2007 .

[9]  M. Gasper,et al.  CHROMATOGRAPHY: LIQUID | Chiral Separations: Macrocyclic Antibiotics , 2007 .

[10]  Lingfeng He,et al.  Development of dinitrophenylated cyclodextrin derivatives for enhanced enantiomeric separations by high-performance liquid chromatography. , 2006, Journal of chromatography. A.

[11]  K. Albert,et al.  Synthesis and characterization of a novel resorcinarene-based stationary phase bearing polar headgroups for use in reversed-phase high-performance liquid chromatography. , 2005, Journal of chromatography. A.

[12]  Amal Moulik,et al.  Trends in environmental analysis. , 2005, Analytical chemistry.

[13]  Min Liu,et al.  Study on the preparation method and performance of a new β-cyclodextrin bonded silica stationary phase for liquid chromatography , 2005 .

[14]  Yuegang Zhang,et al.  Multiple conformations of benzil in resorcinarene-based supramolecular host matrixes. , 2003, The Journal of organic chemistry.

[15]  Milton L. Lee,et al.  Application of diaza-18-crown-6-capped beta-cyclodextrin bonded silica particles as chiral stationary phases for ultrahigh pressure capillary liquid chromatography. , 2003, Journal of chromatography. A.

[16]  U. Menyes,et al.  Separation of cis- and trans-isomers of thioxanthene and dibenz[b,e]oxepin derivatives on calixarene- and resorcinarene-bonded high-performance liquid chromatography stationary phases. , 2002, Journal of chromatography. A.

[17]  H. Claessens.  Trends and progress in the characterization of stationary phases for reversed-phase liquid chromatography , 2001 .

[18]  P. Woo,et al.  Molecular Recognition of Organic Ammonium Ions by Diaza-Crown Ether-Modified β-Cyclodextrin in Aqueous Media , 2000 .

[19]  R. Ludwig.  Calixarenes in analytical and separation chemistry , 2000, Fresenius' journal of analytical chemistry.

[20]  B. Law.  PHARMACEUTICALS | Basic Drugs: Liquid Chromatography , 2000 .

[21]  A. Stalcup,et al.  INCLUSION COMPLEXATION: LIQUID CHROMATOGRAPHY , 2000 .

[22]  S. Harris,et al.  Silica-bonded calixarenes in chromatography : enantioseparations on molecular basket phases for rapid chiral LC , 1998 .

[23]  M. Pietraszkiewicz,et al.  Separation of Pyrimidine Bases on a HPLC Stationary RP-18 Phase Coated with Calix[4]resorcinarene , 1998 .

[24]  R. Smith,et al.  Appendix 6A. Classification and Characterisation of Stationary Phases for Liquid Chromatography (IUPAC Recommendations 1997) | Descriptive Terminology , 1997 .