Topographic Distribution of Catecholaminergic Neurons in the Rat Medulla Oblongata Using Quantitative Three-Dimensional Reconstruction

In 1964 Dahlstrom and Fuxe (3), using the formaldehyde histof luorescence technique, first described a variety of monoamine containing neurons in the brain. A number of studies on the catecholamine (CA) neurons followed, (2, 4–8, 12–19, 24) resulting in the demonstration of the existence of the following populations of CA neurons: adrenaline containing neurons — C cell groups (Hokfelt, Fuxe et al, 1974), noradrenaline containing neurons — A cell groups (Dahlstrom and Fuxe, 1964) and dopamine containing neurons. Historically, the question of monoaminergic neurons located in the brain stem has been addressed using fluorescence histochemistry and immunof luorescence techniques (1,2,3,18,19,30).

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