In APCs, the Autologous Peptides Selected by the Diabetogenic I-Ag7 Molecule Are Unique and Determined by the Amino Acid Changes in the P9 Pocket1
暂无分享,去创建一个
Emil R. Unanue | Osami Kanagawa | Michael L. Gross | Ilan Vidavsky | E. Unanue | I. Vidavsky | M. Gross | O. Kanagawa | A. Suri | K. van der Drift | Anish Suri | Koen van der Drift
[1] L Adorini,et al. The motif for peptide binding to the insulin-dependent diabetes mellitus-associated class II MHC molecule I-Ag7 validated by phage display library. , 2000, International immunology.
[2] E. Unanue,et al. Identification of two distinct properties of class II major histocompatibility complex-associated peptides. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[3] A Sette,et al. Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. , 1992, Science.
[4] K. Parker,et al. Endogenous peptides bound to HLA-A3 possess a specific combination of anchor residues that permit identification of potential antigenic peptides. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[5] P. A. Peterson,et al. Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues. , 1998, Immunity.
[6] G. Nepom,et al. Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. , 1996, Journal of immunology.
[7] Hans-Georg Rammensee,et al. Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules , 2004, Immunogenetics.
[8] E. Unanue,et al. Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[9] E. Unanue,et al. Thymic positive selection and peripheral activation of islet antigen-specific T cells: separation of two diabetogenic steps by an I-A(g7) class II MHC beta-chain mutant. , 1998, Journal of immunology.
[10] R. Tisch,et al. Prevention of diabetes in NOD mice by a mutated I-Ab transgene. , 1998, Diabetes.
[11] M Eisenstein,et al. Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7. , 1997, International immunology.
[12] H. Rammensee,et al. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules , 1991, Nature.
[13] E. Unanue,et al. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. , 1996, Journal of immunology.
[14] I. Cohen,et al. Treatment of NOD diabetes with a novel peptide of the hsp60 molecule induces Th2-type antibodies. , 1997, Journal of autoimmunity.
[15] J. Todd,et al. HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus , 1987, Nature.
[16] W A Hendrickson,et al. Crystal structure of I-Ak in complex with a dominant epitope of lysozyme. , 1998, Immunity.
[17] H. Rammensee,et al. Characterization of naturally occurring minor histocompatibility peptides including H-4 and H-Y. , 1990, Science.
[18] C. Janeway,et al. Self peptides isolated from MHC glycoproteins of non-obese diabetic mice. , 1994, Journal of immunology.
[19] G. Eisenbarth,et al. Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. , 1990, Annual review of immunology.
[20] E. Unanue,et al. The role of I-Ag7 beta chain in peptide binding and antigen recognition by T cells. , 1997, International immunology.
[21] D. Jewell,et al. Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2). , 1997, International immunology.
[22] H. Mcdevitt,et al. The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[23] H. Kikutani,et al. The murine autoimmune diabetes model: NOD and related strains. , 1992, Advances in immunology.
[24] D. Kioussis,et al. Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. , 1995, Journal of immunology.
[25] A. Rudensky,et al. Sequence analysis of peptides bound to MHC class II molecules , 1991, Nature.
[26] E. Unanue,et al. Appreciating the Complexity of MHC Class II Peptide Binding: Lysozyme Peptide and I‐Ak , 1996, Immunological reviews.
[27] I. Cohen,et al. Induction of diabetes in standard mice by immunization with the p277 peptide of a 60‐kDa heat shock protein , 1995, European journal of immunology.
[28] E. Unanue,et al. Isolation and quantitation of a minor determinant of hen egg white lysozyme bound to I-Ak by using peptide-specific immunoaffinity. , 1998, Journal of immunology.
[29] J. Todd,et al. Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[30] M. Dorf,et al. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. , 1986, Science.
[31] D. R. Madden,et al. Identification of self peptides bound to purified HLA-B27 , 1991, Nature.
[32] S. Matsushita,et al. Differential binding of peptides substituted at a putative C-terminal anchor residue to I-Ag7β56Hisβ57Ser and I-Ag7β56Proβ57Asp , 1998, Immunogenetics.
[33] H. Mcdevitt,et al. Identification of immunogenic epitopes of GAD 65 presented by A g7 in non-obese diabetic mice , 1997, Immunogenetics.
[34] William S. Lane,et al. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size , 1992, Nature.
[35] I. Cohen,et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[36] E. Unanue,et al. The lack of consensus for I-A(g7)-peptide binding motifs: is there a requirement for anchor amino acid side chains? , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[37] H. Mcdevitt,et al. The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[38] E. Unanue,et al. Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[39] Don C. Wiley,et al. Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes , 2001, Nature Immunology.
[40] E. Unanue,et al. Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice. , 2000, Immunity.
[41] K. Garcia,et al. A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. , 2000, Science.
[42] Hiroaki Ito,et al. Analysis of the Role of Variation of Major Histocompatibility Complex Class II Expression on Nonobese Diabetic (NOD) Peripheral T Cell Response , 1998, The Journal of experimental medicine.
[43] Vladimir Brusic,et al. A Peptide-binding Motif for I-Ag7, the Class II Major Histocompatibility Complex (MHC) Molecule of NOD and Biozzi AB/H Mice , 1997, The Journal of experimental medicine.
[44] K. Wucherpfennig,et al. pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH , 1999, The Journal of experimental medicine.
[45] I. Cohen,et al. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[46] R. Henderson,et al. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. , 1992, Science.
[47] E. Unanue,et al. Mechanisms and consequences of peptide selection by the I‐Ak class II molecule , 1999, Immunological reviews.
[48] Hans-Georg Rammensee,et al. MHC ligands and peptide motifs: first listing , 2004, Immunogenetics.
[49] R. Tisch,et al. Insulin-Dependent Diabetes Mellitus , 1996, Cell.
[50] E. Unanue,et al. Cutting Edge: Thymic Positive Selection and Peripheral Activation of Islet Antigen-Specific T Cells: Separation of Two Diabetogenic Steps by an I-Ag7 Class II MHC β-Chain Mutant , 1998, The Journal of Immunology.
[51] J. Todd,et al. Genetic control of autoimmune diabetes in the NOD mouse. , 1995, Annual review of immunology.
[52] E. Unanue,et al. Quantitation of Lysozyme Peptides Bound to Class II MHC Molecules Indicates Very Large Differences in Levels of Presentation1 , 2001, The Journal of Immunology.
[53] William Arbuthnot Sir Lane,et al. Self-peptides bound to the type I diabetes associated class II MHC molecules HLA-DQ1 and HLA-DQ8. , 1994, International immunology.
[54] V. Apostolopoulos,et al. The I-Ag7 MHC Class II Molecule Linked to Murine Diabetes Is a Promiscuous Peptide Binder1 , 2000, The Journal of Immunology.
[55] K. Ballingall,et al. The DY sub-region of the sheep MHC contains an A/B gene pair , 2004, Immunogenetics.
[56] Hans-Georg Rammensee,et al. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells , 1990, Nature.