Imaging markers of mild cognitive impairment: Multivariate analysis of CBF SPECT

This study aimed to investigate cross-sectional and longitudinal changes of regional cerebral blood flow (rCBF) in preclinical dementia using single photon emission computed tomography (SPECT). SPECT and cognitive function were investigated in 39 mild cognitive impairment (MCI) subjects and 20 age-matched controls. All subjects were followed longitudinally 19 months on average, 16 MCI subjects progressed to Alzheimer's disease (AD), who were retrospectively defined as progressive mild cognitive impairment (PMCI) at baseline and 23 MCI subjects remained stable and were defined as stable mild cognitive impairment (SMCI) at baseline. SPECT was performed both at the initial investigation and at follow-up. Image data were analyzed using multivariate analysis, SPM and volume of interest (VOI)-based analysis. Significant covariate patterns were derived, which differentiate among PMCI, SMCI and controls at baseline as well as describe the longitudinal progression of PMCI. The combined SPECT and neuropsychology increased the diagnostic accuracy of PMCI at baseline. SPECT and neuropsychological testing can be used objectively for both baseline diagnosis and to monitor changes in brain function during very early AD.

[1]  Yaakov Stern,et al.  Relation of cognitive reserve and task performance to expression of regional covariance networks in an event-related fMRI study of nonverbal memory☆ , 2003, NeuroImage.

[2]  Lars-Olof Wahlund,et al.  Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment , 2002, BMC neurology.

[3]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[4]  V. Dhawan,et al.  Reproducibility of regional metabolic covariance patterns: comparison of four populations. , 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[5]  Ove Almkvist,et al.  Voxel- and VOI-based analysis of SPECT CBF in relation to clinical and psychological heterogeneity of mild cognitive impairment , 2003, NeuroImage.

[6]  T. Ohnishi,et al.  Longitudinal Evaluation of Early Alzheimer's Disease Using Brain Perfusion Spect the Recruitment Was For , 2000 .

[7]  Piotr J. Slomka,et al.  Automated segmentation and registration technique for HMPAO-SPECT imaging of Alzheimer's patients , 2000, Medical Imaging: Image Processing.

[8]  B L Holman,et al.  The scintigraphic appearance of Alzheimer's disease: a prospective study using technetium-99m-HMPAO SPECT. , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  K. Ishii,et al.  The clinical utility of visual evaluation of scintigraphic perfusion patterns for Alzheimer's disease using I-123 IMP SPECT. , 1996, Clinical nuclear medicine.

[10]  J. Morris,et al.  Current concepts in mild cognitive impairment. , 2001, Archives of neurology.

[11]  E. Zarahn,et al.  An event-related fMRI study of the neurobehavioral impact of sleep deprivation on performance of a delayed-match-to-sample task. , 2004, Brain research. Cognitive brain research.

[12]  D. Anchisi,et al.  Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD , 2006, Neurobiology of Aging.

[13]  Yaakov Stern,et al.  A New Approach to Spatial Covariance Modeling of Functional Brain Imaging Data: Ordinal Trend Analysis , 2005, Neural Computation.

[14]  B. Winblad,et al.  Mild cognitive impairment--an early stage of Alzheimer's disease? , 1998, Journal of neural transmission. Supplementum.

[15]  D. A. Bennett,et al.  Natural history of mild cognitive impairment in older persons , 2002, Neurology.

[16]  L. Bäckman,et al.  Episodic memory functioning in a community-based sample of old adults with major depression: utilization of cognitive support. , 1994, Journal of abnormal psychology.