Multisensory integration mechanisms during aging

The rapid demographical shift occurring in our society implies that understanding of healthy aging and age-related diseases is one of our major future challenges. Sensory impairments have an enormous impact on our lives and are closely linked to cognitive functioning. Due to the inherent complexity of sensory perceptions, we are commonly presented with a complex multisensory stimulation and the brain integrates the information from the individual sensory channels into a unique and holistic percept. The cerebral processes involved are essential for our perception of sensory stimuli and becomes especially important during the perception of emotional content. Despite ongoing deterioration of the individual sensory systems during aging, there is evidence for an increase in, or maintenance of, multisensory integration processing in aging individuals. Within this comprehensive literature review on multisensory integration we aim to highlight basic mechanisms and potential compensatory strategies the human brain utilizes to help maintain multisensory integration capabilities during healthy aging to facilitate a broader understanding of age-related pathological conditions. Further our goal was to identify where further research is needed.

[1]  Jeffrey N. Browndyke,et al.  Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease , 2013, Alzheimer's & Dementia.

[2]  Anthony Randal McIntosh,et al.  Visual dominance and multisensory integration changes with age , 2013, NeuroImage.

[3]  T. Elbert,et al.  Development of large-scale functional networks over the lifespan , 2012, Neurobiology of Aging.

[4]  Jeannette R. Mahoney,et al.  The effect of multisensory cues on attention in aging , 2012, Brain Research.

[5]  Daniel A. Schneider,et al.  The differential contribution of facial expressions, prosody, and speech content to empathy , 2012, Cognition & emotion.

[6]  R. Kahn,et al.  Human brain changes across the life span: A review of 56 longitudinal magnetic resonance imaging studies , 2012, Human brain mapping.

[7]  K. Mathiak,et al.  Multisensory emotions: perception, combination and underlying neural processes , 2012, Reviews in the neurosciences.

[8]  C. Grady The cognitive neuroscience of ageing , 2012, Nature Reviews Neuroscience.

[9]  B. Berglund,et al.  Is Loss in Odor Sensitivity Inevitable to the Aging Individual? A Study of “Successfully Aged” Elderly , 2012, Chemosensory Perception.

[10]  Frank Schneider,et al.  Multimodal human communication — Targeting facial expressions, speech content and prosody , 2012, NeuroImage.

[11]  M. Filippi,et al.  Microstructural changes and atrophy in brain white matter tracts with aging , 2012, Neurobiology of Aging.

[12]  Jeroen van der Grond,et al.  Imaging the default mode network in aging and dementia. , 2012, Biochimica et biophysica acta.

[13]  B. Turetsky,et al.  Crossmodal interactions in audiovisual emotion processing , 2012, NeuroImage.

[14]  M. Fabiani It was the best of times, it was the worst of times: a psychophysiologist's view of cognitive aging. , 2012, Psychophysiology.

[15]  A. Chatterjee,et al.  Staying responsive to the world: Modality‐specific and ‐nonspecific contributions to speeded auditory, tactile, and visual stimulus detection , 2012, Human brain mapping.

[16]  Jeannette R. Mahoney,et al.  Multisensory integration across the senses in young and old adults , 2011, Brain Research.

[17]  T. Kircher,et al.  Supramodal Representation of Emotions , 2011, The Journal of Neuroscience.

[18]  Charles Spence,et al.  Crossmodal semantic priming by naturalistic sounds and spoken words enhances visual sensitivity. , 2011, Journal of experimental psychology. Human perception and performance.

[19]  Angela R. Laird,et al.  Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: a meta-analysis , 2011, Brain Structure and Function.

[20]  Hartwig R. Siebner,et al.  The left fusiform gyrus hosts trisensory representations of manipulable objects , 2011, NeuroImage.

[21]  T. Hummel,et al.  Auditory-olfactory integration: congruent or pleasant sounds amplify odor pleasantness. , 2011, Chemical senses.

[22]  Frank Schneider,et al.  Incongruence effects in crossmodal emotional integration , 2011, NeuroImage.

[23]  C. Spence Crossmodal correspondences: A tutorial review , 2011, Attention, perception & psychophysics.

[24]  Frank Schneider,et al.  Processing of disgusted faces is facilitated by odor primes: A functional MRI study , 2010, NeuroImage.

[25]  Julia M. Stephen,et al.  Aging-related changes in auditory and visual integration measured with MEG , 2010, Neuroscience Letters.

[26]  Liang Wang,et al.  Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals , 2010, NeuroImage.

[27]  U. Habel,et al.  Multisensory integration of emotionally valenced olfactory-visual information in patients with schizophrenia and healthy controls. , 2010, Journal of psychiatry & neuroscience : JPN.

[28]  Akram Bakkour,et al.  Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability , 2010, Hippocampus.

[29]  Wolfgang Grodd,et al.  Cerebral representation of non-verbal emotional perception: fMRI reveals audiovisual integration area between voice- and face-sensitive regions in the superior temporal sulcus , 2009, Neuropsychologia.

[30]  Matthias L. Schroeter,et al.  Neural correlates of Alzheimer's disease and mild cognitive impairment: A systematic and quantitative meta-analysis involving 1351 patients , 2009, NeuroImage.

[31]  G. Schellenberg,et al.  Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings. , 2009, Archives of neurology.

[32]  Alzheimer's Disease Neuroimaging Initiative,et al.  Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI) , 2009, NeuroImage.

[33]  Jennifer L. Mozolic,et al.  Suppression of multisensory integration by modality-specific attention in aging , 2009, Neuroreport.

[34]  M. L. Demattè,et al.  Olfactory discrimination: when vision matters? , 2008, Chemical senses.

[35]  A. Diederich,et al.  Assessing age-related multisensory enhancement with the time-window-of-integration model , 2008, Neuropsychologia.

[36]  Michael S. Beauchamp,et al.  Touch, sound and vision in human superior temporal sulcus , 2008, NeuroImage.

[37]  R. Cabeza,et al.  Que PASA? The posterior-anterior shift in aging. , 2008, Cerebral cortex.

[38]  J. Price Multisensory Convergence in the Orbital and Ventrolateral Prefrontal Cortex , 2008 .

[39]  T. Stanford,et al.  Multisensory integration: current issues from the perspective of the single neuron , 2008, Nature Reviews Neuroscience.

[40]  Justin L. Vincent,et al.  Disruption of Large-Scale Brain Systems in Advanced Aging , 2007, Neuron.

[41]  J B Poline,et al.  Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease. , 2007, Brain : a journal of neurology.

[42]  Rajita Sinha,et al.  Greater activation of the “default” brain regions predicts stop signal errors , 2007, NeuroImage.

[43]  Paul J. Laurienti,et al.  Modality-specific selective attention attenuates multisensory integration , 2007, Experimental Brain Research.

[44]  Paul J Laurienti,et al.  Age-related multisensory enhancement in a simple audiovisual detection task , 2007, Neuroreport.

[45]  D. Yan,et al.  Ageing and hearing loss , 2007, The Journal of pathology.

[46]  N. Raz,et al.  Differential aging of the brain: Patterns, cognitive correlates and modifiers , 2006, Neuroscience & Biobehavioral Reviews.

[47]  M. Wallace,et al.  Enhanced multisensory integration in older adults , 2006, Neurobiology of Aging.

[48]  Charles Spence,et al.  Cross-modal associations between odors and colors. , 2006, Chemical senses.

[49]  N. Rawson Olfactory loss in aging. , 2006, Science of aging knowledge environment : SAGE KE.

[50]  Anthony Randal McIntosh,et al.  Age-related Changes in Brain Activity across the Adult Lifespan , 2006, Journal of Cognitive Neuroscience.

[51]  C. Mathers,et al.  Global prevalence of dementia: a Delphi consensus study , 2005, The Lancet.

[52]  D. Small,et al.  Odor/taste integration and the perception of flavor , 2005, Experimental Brain Research.

[53]  M. Sommers,et al.  Auditory-Visual Speech Perception and Auditory-Visual Enhancement in Normal-Hearing Younger and Older Adults , 2005, Ear and hearing.

[54]  A. Toga,et al.  Mapping Changes in the Human Cortex throughout the Span of Life , 2004, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[55]  W. David Hairston,et al.  Multisensory enhancement of localization under conditions of induced myopia , 2003, Experimental Brain Research.

[56]  R. Dolan,et al.  The Nose Smells What the Eye Sees Crossmodal Visual Facilitation of Human Olfactory Perception , 2003, Neuron.

[57]  B J Shepstone,et al.  Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease. , 2002, Brain : a journal of neurology.

[58]  G. Calvert Crossmodal processing in the human brain: insights from functional neuroimaging studies. , 2001, Cerebral cortex.

[59]  M. Raichle,et al.  Searching for a baseline: Functional imaging and the resting human brain , 2001, Nature Reviews Neuroscience.

[60]  K. Zilles,et al.  Polymodal Motion Processing in Posterior Parietal and Premotor Cortex A Human fMRI Study Strongly Implies Equivalencies between Humans and Monkeys , 2001, Neuron.

[61]  H. Nagata,et al.  The merging of the senses: integration of subthreshold taste and smell , 2000, Nature Neuroscience.

[62]  K S Helfer,et al.  Auditory and auditory-visual recognition of clear and conversational speech by older adults. , 1998, Journal of the American Academy of Audiology.

[63]  Leslie G. Ungerleider,et al.  Age-related changes in cortical blood flow activation during visual processing of faces and location , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[64]  P. D. Spear,et al.  Neural bases of visual deficits during aging , 1993, Vision Research.

[65]  B E Walden,et al.  Benefit from visual cues in auditory-visual speech recognition by middle-aged and elderly persons. , 1993, Journal of speech and hearing research.

[66]  M A Meredith,et al.  Multisensory Integration , 1990 .

[67]  B. Stein,et al.  Visual, auditory, and somatosensory convergence on cells in superior colliculus results in multisensory integration. , 1986, Journal of neurophysiology.

[68]  B. Stein,et al.  Interactions among converging sensory inputs in the superior colliculus. , 1983, Science.

[69]  Jennifer L. Mozolic,et al.  Multisensory Integration and Aging , 2012 .

[70]  M. Filippi,et al.  Structural and functional network connectivity breakdown in Alzheimer’s disease studied with magnetic resonance imaging techniques. , 2011, Journal of Alzheimer's disease : JAD.

[71]  D. Roane,et al.  Assessment of Stimulus Preferences in Snoezelen Therapy for the Elderly with Dementia , 2010 .

[72]  Vanessa Taler,et al.  Audio-visual speech perception in mild cognitive impairment and healthy elderly controls , 2009, AVSP.

[73]  Denise C. Park,et al.  The adaptive brain: aging and neurocognitive scaffolding. , 2009, Annual review of psychology.

[74]  Gilles Pourtois,et al.  Investigating audiovisual integration of emotional signals in the human brain. , 2006, Progress in brain research.

[75]  M. Falkenstein,et al.  Effects of aging on slowing of motor-response generation. , 2006, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[76]  A. J. King,et al.  Integration of visual and auditory information in bimodal neurones in the guinea-pig superior colliculus , 2004, Experimental Brain Research.

[77]  A. King,et al.  Multisensory integration. , 1993, Science.

[78]  A Wingfield,et al.  Age differences in processing information from television news: the effects of bisensory augmentation. , 1990, Journal of gerontology.