Effect of Pravastatin on Human Sleep

Abstract: To evaluate the effect of pravastatin, an HMG‐CoA reductase inhibitor, on sleep, the drug or a placebo was administered to 5 healthy adults for 16 days by the double‐blind method. Pravastatin caused no changes in sleep parameters. This indicates that it had no effect on human sleep for the following possible reasons: Being hydrophilic, the drug does not readily cross the blood‐brain barrier. It does not inhibit prostaglandin D2 synthase, a possible sleep‐inducing substance. It was thought that a decrease in the total cholesterol level in the blood has no effect on sleep in healthy adults.

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