Delay, discriminatory, and modality specific neurons in striatum and pallidum during short-term memory tasks

The function of the striatum and its integrative capacities is addressed. The activity of single neurons in behaving Macaca mulatta is studied. Two new classes of neurons were found. In the striatum, but not in the pallidum, these neurons were visual modality specific. These neurons may represent a conjunction of sensory, mnemonic and motor information, and may be concerned with decisions about the emission or withholding of movements. The frontal dysfunction hypothesis of cognitive deficits in Parkinson's disease is considered.

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