Crystal structure of wild-type (WT) human Glutamate oxaloacetate transaminase 1 (GOT1)
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L. Cantley | A. Kimmelman | C. Lyssiotis | L. Lairson | Edouard Mullarky | Z. Assar | Lin Lin | M. Holt | Oksana Mashadova | A. Stein | R. Zavareh | J. Anglin | D. Haldar | Daniel M. Kremer
[1] L. Cantley,et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. , 2018, Bioorganic & medicinal chemistry letters.
[2] S. Monti,et al. Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells , 2018, EMBO reports.
[3] Jerry M. Parks,et al. Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme , 2017, Nature Communications.
[4] Paul Emsley,et al. Tools for ligand validation in Coot , 2017, Acta crystallographica. Section D, Structural biology.
[5] Jerry M. Parks,et al. Direct evidence that an extended hydrogen-bonding network influences activation of pyridoxal 5′-phosphate in aspartate aminotransferase , 2017, The Journal of Biological Chemistry.
[6] C. Lyssiotis,et al. Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. , 2017, Cancer cell.
[7] L. Cantley,et al. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion , 2016, Nature.
[8] Jennifer L. Knight,et al. OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins. , 2016, Journal of chemical theory and computation.
[9] Xiuping Jiang,et al. Expression, purification and preliminary crystallographic studies of human glutamate oxaloacetate transaminase 1 (GOT1). , 2015, Protein expression and purification.
[10] D. Sabatini,et al. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis , 2015, Cell.
[11] A. Stenzinger,et al. GOT1/AST1 expression status as a prognostic biomarker in pancreatic ductal adenocarcinoma , 2015, Oncotarget.
[12] A. D'arcy,et al. Microseed matrix screening for optimization in protein crystallization: what have we learned? , 2014, Acta crystallographica. Section F, Structural biology communications.
[13] Woody Sherman,et al. Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments , 2013, Journal of Computer-Aided Molecular Design.
[14] John M. Asara,et al. Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.
[15] Pierre Michel,et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. , 2011, The New England journal of medicine.
[16] N. Pannu,et al. REFMAC5 for the refinement of macromolecular crystal structures , 2011, Acta crystallographica. Section D, Biological crystallography.
[17] Randy J. Read,et al. Overview of the CCP4 suite and current developments , 2011, Acta crystallographica. Section D, Biological crystallography.
[18] W. Sherman,et al. Prediction of Absolute Solvation Free Energies using Molecular Dynamics Free Energy Perturbation and the OPLS Force Field. , 2010, Journal of chemical theory and computation.
[19] David Calkins,et al. Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution , 2010, J. Comput. Aided Mol. Des..
[20] A. Lane,et al. Targeting aspartate aminotransferase in breast cancer , 2008, Breast Cancer Research.
[21] Jeremy R. Greenwood,et al. Epik: a software program for pKa prediction and protonation state generation for drug-like molecules , 2007, J. Comput. Aided Mol. Des..
[22] Matthew P. Repasky,et al. Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. , 2004, Journal of medicinal chemistry.
[23] W. L. Jorgensen,et al. The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. , 1988, Journal of the American Chemical Society.
[24] A. Jemal,et al. Cancer statistics, 2016 , 2016, CA: a cancer journal for clinicians.
[25] Christian M. Metallo,et al. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth , 2013 .
[26] Alexei Vagin,et al. Molecular replacement with MOLREP. , 2010, Acta crystallographica. Section D, Biological crystallography.
[27] Z. Otwinowski,et al. [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.