Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage.
暂无分享,去创建一个
M. Bhargava | P. Torzilli | Seonghun Park | P A Torzilli | M Bhargava | S Park | C T C Chen | C. T. Chen | S. Park | Christopher T. Chen
[1] P. Roughley,et al. Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro. , 1995, The Biochemical journal.
[2] P. Torzilli,et al. Effect of Compressive Strain on Cell Viability in Statically Loaded Articular Cartilage , 2006, Biomechanics and modeling in mechanobiology.
[3] D. A. Lee,et al. Integrin-mediated mechanotransduction in IL-1β stimulated chondrocytes , 2006 .
[4] S. Agarwal,et al. Biomechanical signals inhibit IKK activity to attenuate NF-kappaB transcription activity in inflamed chondrocytes. , 2007, Arthritis and rheumatism.
[5] G. Lust,et al. Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system. , 1997, Journal of biomechanics.
[6] J. Steinmeyer,et al. Proteoglycan metabolism and viability of articular cartilage explants as modulated by the frequency of intermittent loading. , 2003, Osteoarthritis and cartilage.
[7] D. Eyre,et al. The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. , 2003, Arthritis and rheumatism.
[8] W. B. van den Berg,et al. Elucidation of IL-1/TGF-beta interactions in mouse chondrocyte cell line by genome-wide gene expression. , 2005, Osteoarthritis and cartilage.
[9] T. Burn,et al. Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). , 2002, Matrix biology : journal of the International Society for Matrix Biology.
[10] M. Tortorella,et al. Inhibition of ADAM-TS4 and ADAM-TS5 Prevents Aggrecan Degradation in Osteoarthritic Cartilage* , 2002, The Journal of Biological Chemistry.
[11] J. Kreeger,et al. Characterizing osteochondrosis in the dog: potential roles for matrix metalloproteinases and mechanical load in pathogenesis and disease progression. , 2005, Osteoarthritis and cartilage.
[12] S. Chien,et al. Biomechanical regulation of matrix metalloproteinase‐9 in cultured chondrocytes , 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[13] I. Otterness,et al. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. , 2002, Matrix biology : journal of the International Society for Matrix Biology.
[14] D. Buttle,et al. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. , 1986, Biochimica et biophysica acta.
[15] Farshid Guilak,et al. Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. , 2003, Journal of applied physiology.
[16] P. Patwari,et al. Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines. , 2003, Arthritis and rheumatism.
[17] M. Bhargava,et al. Time, stress, and location dependent chondrocyte death and collagen damage in cyclically loaded articular cartilage , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[18] P. Torzilli,et al. Effect of tissue maturity on cell viability in load-injured articular cartilage explants. , 2005, Osteoarthritis and cartilage.
[19] Alan J Grodzinsky,et al. Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. , 2004, Arthritis and rheumatism.
[20] J. Steinmeyer,et al. Fibronectin metabolism of cartilage explants in response to the frequency of intermittent loading , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[21] E. Arner. Aggrecanase-mediated cartilage degradation. , 2002, Current opinion in pharmacology.
[22] L. Bian,et al. Physiologic deformational loading does not counteract the catabolic effects of interleukin-1 in long-term culture of chondrocyte-seeded agarose constructs. , 2008, Journal of biomechanics.
[23] B. Caterson,et al. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase. , 1998, Osteoarthritis and cartilage.
[24] A. Poole,et al. Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration. , 2004, Osteoarthritis and cartilage.
[25] P. E. Clark,et al. Compression loading in vitro regulates proteoglycan synthesis by tendon fibrocartilage. , 1992, Archives of biochemistry and biophysics.
[26] T. Sato,et al. Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. , 2001, Osteoarthritis and cartilage.
[27] A. Grodzinsky,et al. Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression. , 2005, Arthritis and rheumatism.
[28] J. Deschner,et al. Biomechanical strain regulates TNFR2 but not TNFR1 in TMJ cells. , 2007, Journal of biomechanics.
[29] J. Steinmeyer,et al. Collagen biosynthesis of mechanically loaded articular cartilage explants. , 2005, Osteoarthritis and cartilage.
[30] P. Torzilli,et al. Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage. , 2004, Osteoarthritis and cartilage.
[31] J. Brand,et al. Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs , 2008, Arthritis Research & Therapy.
[32] P. Torzilli,et al. Continuous cyclic load reduces proteoglycan release from articular cartilage. , 1998, Osteoarthritis and cartilage.
[33] A. Kerin,et al. In vitro models for investigation of the effects of acute mechanical injury on cartilage. , 2001, Clinical orthopaedics and related research.
[34] R. Gassner,et al. Cyclic tensile stress exerts antiinflammatory actions on chondrocytes by inhibiting inducible nitric oxide synthase. , 1999, Journal of immunology.
[35] W. O’Brien,et al. Modified assay for determination of hydroxyproline in a tissue hydrolyzate. , 1980, Clinica chimica acta; international journal of clinical chemistry.
[36] L. Bian,et al. Differences in interleukin-1 response between engineered and native cartilage. , 2008, Tissue engineering. Part A.
[37] M. Tortorella,et al. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation. , 2001, Osteoarthritis and cartilage.
[38] D. Jackson,et al. Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids. , 1995, The Biochemical journal.
[39] D. Griggs,et al. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. , 2007, Arthritis and rheumatism.
[40] D. Bader,et al. Dynamic compression counteracts IL-1β-induced release of nitric oxide and PGE2by superficial zone chondrocytes cultured in agarose constructs , 2003 .
[41] J. Deschner,et al. Biomechanical signals exert sustained attenuation of proinflammatory gene induction in articular chondrocytes. , 2006, Osteoarthritis and cartilage.
[42] W. Horton,et al. Cartilage viability after repetitive loading: a preliminary report. , 2002, Osteoarthritis and cartilage.
[43] A. Goodship,et al. Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. , 2005, Osteoarthritis and Cartilage.
[44] Albert C. Chen,et al. Depth‐dependent confined compression modulus of full‐thickness bovine articular cartilage , 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[45] Y. Kato,et al. The effects of high magnitude cyclic tensile load on cartilage matrix metabolism in cultured chondrocytes. , 2000, European journal of cell biology.
[46] J. Deschner,et al. Regulation of matrix metalloproteinase expression by dynamic tensile strain in rat fibrochondrocytes. , 2006, Osteoarthritis and cartilage.
[47] M. Karsdal,et al. MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays. , 2007, Osteoarthritis and cartilage.
[48] T. Sadowski,et al. Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes. , 2001, Osteoarthritis and cartilage.
[49] J. Ralphs,et al. Organisation of the chondrocyte cytoskeleton and its response to changing mechanical conditions in organ culture , 1999, Journal of anatomy.