Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development Running title: Genome-wide association study of LV phenotypes

Nay Aung, MBBS, MRCP1,2,3#; Jose D Vargas, MD, DPhil4#; Chaojie Yang, MSc5; Claudia P Cabrera, PhD6; Helen R Warren, PhD1,2; Kenneth Fung, MBBS, MRCP1,2,3; Evan Tzanis, PhD6; Michael R Barnes, PhD6; Jerome I Rotter, MD7; Kent D Taylor, MD7; Ani W Manichaikul, PhD5; Joao AC Lima, MD8; David A Bluemke, MD9; Stefan K Piechnik, D.Sc10; Stefan Neubauer, MD, FRCP, FMedSci10; Patricia B Munroe, PhD1,2#*; Steffen E Petersen, MD, DPhil, MPH, FRCP1,2,3#*

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