Implications of HIV variability for transmission: scientific and policy issues. Expert Group of the Joint United Nations Programme on HIV/AIDS.

Current patterns of population migration and of national and international travel promote the emergence and the rapid spread of infectious agents. One of the most important pandemics of this century, fuelled by the increasingly global mixing habits of the world’s population, is that of HIV/AIDS. According to the estimates of the Joint United Nations Programme on HIV/AIDS (UNAIDS), since the start of the global epidemic until 1 July 1996, approximately 28 million people have been infected with HIV. The majority of all infections in adults (approximately 70%) have been transmitted as a result of unprotected heterosexual intercourse. The contribution of other modes of transmission to the global epidemic is more limited: 8–10% cases are by mother-to-child transmission, 5–10% infections transmitted via homosexual (male-to-male) intercourse, 5–10% via sharing HIV-infected injection equipment by drug users, and 3–5% as a result of transfusion of HIV-infected blood and blood products [1].

[1]  A. Tanuri,et al.  A nationwide effort to sistematically monitor HIV-1 diversity in Brazil: preliminary results. Brazilian Network for the HIV-1 Isolation and Characterization. , 1996, Memorias do Instituto Oswaldo Cruz.

[2]  P. Kaleebu,et al.  Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO Network for HIV Isolation and Characterization , 1996, Journal of virology.

[3]  D. Ho,et al.  HIV-1 subtype and second-receptor use , 1996, Nature.

[4]  H Hui,et al.  The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin , 1996, Journal of virology.

[5]  D. Ho,et al.  Progesterone implants enhance SIV vaginal transmission and early virus load , 1996, Nature Medicine.

[6]  J J Goedert,et al.  Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene , 1996, Science.

[7]  D. Gotte,et al.  Full-length sequence and mosaic structure of a human immunodeficiency virus type 1 isolate from Thailand , 1996, Journal of virology.

[8]  M. Marsh,et al.  Chemokine receptors - the new frontier for AIDS research. , 1996, Chemistry & biology.

[9]  T. Quinn,et al.  Global burden of the HIV pandemic , 1996, The Lancet.

[10]  E. Fenyö HIV-1 biological phenotype varies with severity of infection across HIV-1 genetic subtypes. , 1996, Antibiotics and chemotherapy.

[11]  R. Anderson,et al.  Implications of genetic variability in HIV for epidemiology and public health , 1996, The Lancet.

[12]  R. Detels,et al.  HIV type 1 subtype E in commercial sex workers and injection drug users in southern Vietnam. , 1996, AIDS research and human retroviruses.

[13]  R. Marlink Lessons from the second AIDS virus, HIV-2. , 1996, AIDS.

[14]  John W. Mellors,et al.  Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma , 1996, Science.

[15]  D. Ho,et al.  Viral Counts Count in HIV Infection , 1996, Science.

[16]  M. Laga,et al.  Longstanding presence in Belgians of multiple non-B HIV-1 subtypes , 1996, The Lancet.

[17]  R. Osathanondh,et al.  HIV-1 Langerhans' Cell Tropism Associated with Heterosexual Transmission of HIV , 1996, Science.

[18]  J. Sodroski,et al.  Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization , 1996, Journal of virology.

[19]  A. Kozlov,et al.  Antigenic and genetic relations between different HIV-1 subtypes in Russia , 1996 .

[20]  D J Hu,et al.  The emerging genetic diversity of HIV. The importance of global surveillance for diagnostics, research, and prevention. , 1996, JAMA.

[21]  R. Siliciano,et al.  Cellular immune responses to HIV‐1 in progressive and non‐progressive infections , 1996, AIDS.

[22]  C. Caceres,et al.  HIV/AIDS in Latin America and the Caribbean: an update , 1996, AIDS.

[23]  I. de Vincenzi,et al.  Probabilities of sexual HIV‐1 transmission , 1996, AIDS.

[24]  G. Schochetman,et al.  Genetic variability of HIV‐1 , 1996, AIDS.

[25]  B. Korber,et al.  Inter- and intraclade neutralization of human immunodeficiency virus type 1: genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 antigenic serotypes , 1996, Journal of virology.

[26]  I. Keet,et al.  The role of host genetics in the natural history of HIV‐1 infection: the needles in the haystack , 1996, AIDS.

[27]  A I Spira,et al.  Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques , 1996, The Journal of experimental medicine.

[28]  P. Rowe HIV subtypes raise vaccine anxieties. , 1996, Lancet.

[29]  J. Mascola,et al.  Multiple introductions of HIV-1 subtype E into the western hemisphere , 1995, The Lancet.

[30]  J. Cohen AIDS Research: Differences in HIV Strains May Underlie Disease Patterns , 1995, Science.

[31]  D. Ho,et al.  Genetic analysis of human immunodeficiency virus type 1 strains from patients in Cyprus: identification of a new subtype designated subtype I , 1995, Journal of virology.

[32]  C. Williamson,et al.  HIV-1 subtypes in different risk groups in South Africa , 1995, The Lancet.

[33]  J. Mullins,et al.  Determination of HIV‐1 subtypes in injecting drug users in Bangkok, Thailand, using peptide‐binding enzyme immunoassay, and heteroduplex mobility assay: evidence of increasing infection with HIV‐1 subtype E , 1995, AIDS.

[34]  G. Kapoor,et al.  A genetic analysis of HIV‐1 from Punjab, India reveals the presence of multiple variants , 1995, AIDS.

[35]  J. Goudsmit,et al.  Simultaneous introduction of distinct HIV‐1 subtypes into different risk groups in Russia, Byelorussia and Lithuania , 1995, AIDS.

[36]  E. Domingo,et al.  Molecular characterization of human immunodeficiency virus type 1 isolates from Venezuela. , 1995, AIDS research and human retroviruses.

[37]  P. Phanuphak,et al.  HIV-1 subtypes and male-to-female transmission in Thailand , 1995, The Lancet.

[38]  C. Luo,et al.  HIV-1 subtype C in China , 1995, The Lancet.

[39]  D. Ho,et al.  Sequence diversity of V1 and V2 domains of gp120 from human immunodeficiency virus type 1: lack of correlation with viral phenotype , 1995, Journal of virology.

[40]  J. Mascola,et al.  Dual infection with human immunodeficiency virus type 1 of distinct envelope subtypes in humans. , 1995, The Journal of infectious diseases.

[41]  P. Sharp,et al.  Recombination in HIV-1 , 1995, Nature.

[42]  J. Parry,et al.  At least five HIV-1 sequence subtypes (A, B, C, D, A/E) occur in England. , 1995, AIDS research and human retroviruses.

[43]  D. Ho,et al.  Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. , 1995, The New England journal of medicine.

[44]  Groen,et al.  Genetic diversity of the envelope glycoprotein from human immunodeficiency virus type 1 isolates of African origin , 1995, Journal of virology.

[45]  J. Todd,et al.  Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: ra , 1995 .

[46]  A. Farmer,et al.  Heterogeneity of HIV-1 and HIV-2. , 1995, AIDS.

[47]  R. Hayes,et al.  Variations in HIV prevalence between urban areas in sub-Saharan Africa: do we understand them? , 1995, AIDS.

[48]  J. Mullins,et al.  Identification of an env G subtype and heterogeneity of HIV‐1 strains in the Russian Federation and Belarus , 1994, AIDS.

[49]  S. Osmanov HIV Type 1 Variation in World Health Organization-Sponsored Vaccine Evaluation Sites: Genetic Screening, Sequence Analysis, and Preliminary Biological Characterization of Selected Viral Strains , 1994 .

[50]  E. G. Shpaer,et al.  Rapid genetic characterization of HIV type 1 strains from four World Health Organization-sponsored vaccine evaluation sites using a heteroduplex mobility assay. WHO Network for HIV Isolation and Characterization. , 1994, AIDS research and human retroviruses.

[51]  Characterization,et al.  Syncytium-inducing and non-syncytium-inducing capacity of human immunodeficiency virus type 1 subtypes other than B: phenotypic and genotypic characteristics. WHO Network for HIV Isolation and Characterization. , 1994, AIDS research and human retroviruses.

[52]  M. Kalish,et al.  Antigenic variation and serotyping of HIV type 1 from four World Health Organization-sponsored HIV vaccine sites. WHO Network for HIV Isolation and Characterization. , 1994, AIDS research and human retroviruses.

[53]  P. Kaleebu,et al.  Serotyping HIV type 1 by antibody binding to the V3 loop: relationship to viral genotype. WHO Network for HIV Isolation and Characterization. , 1994, AIDS research and human retroviruses.

[54]  E. G. Shpaer,et al.  Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil , 1994, Journal of virology.

[55]  T. Mastro,et al.  HIV-1 subtype E in Yunnan, China , 1994, The Lancet.

[56]  P. Piot,et al.  Genotypic subtypes of HIV‐1 in Cameroon , 1994, AIDS.

[57]  H. Gayle,et al.  Prospective comparison of mother-to-child transmission of HIV-1 and HIV-2 in Abidjan, Ivory Coast. , 1994, JAMA.

[58]  P. Piot,et al.  Condom promotion, sexually transmitted diseases treatment, and declining incidence of HIV-1 infection in female Zairian sex workers , 1994, The Lancet.

[59]  T. Mastro,et al.  Estimating the number of HIV-infected injection drug users in Bangkok: a capture--recapture method. , 1994, American journal of public health.

[60]  M. Peeters,et al.  Genetic and phylogenetic analysis of env subtypes G and H in central Africa. , 1994, AIDS research and human retroviruses.

[61]  F. Brun-Vézinet,et al.  HIV-1/HIV-2 seronegativity in HIV-1 subtype 0 infected patients , 1994, The Lancet.

[62]  P. Kaleebu,et al.  Molecular epidemiology of HIV‐1 in the former Soviet Union: analysis of env V3 sequences and their correlation with epidemiologic data , 1994, AIDS.

[63]  P. Sharp,et al.  HIV-1 sequence subtype D in the United States. , 1994, AIDS research and human retroviruses.

[64]  I. Thior,et al.  Slower heterosexual spread of HIV-2 than HIV-1 , 1994, The Lancet.

[65]  S. Knapp,et al.  A new subtype of human immunodeficiency virus type 1 (MVP-5180) from Cameroon , 1994, Journal of virology.

[66]  J. Levy,et al.  Characterization of human immunodeficiency virus type 1 isolates from children in Romania: identification of a new envelope subtype. , 1994, The Journal of infectious diseases.

[67]  G. Satten,et al.  Probability of female-to-male transmission of HIV-1 in Thailand , 1994, The Lancet.

[68]  F. Gao,et al.  Origins and diversity of human immunodeficiency viruses , 1994 .

[69]  Y. Takebe,et al.  The molecular epidemiology of HIV in Asia. , 1994, AIDS.

[70]  E. G. Shpaer,et al.  Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes. , 1993, Science.

[71]  H. Gayle,et al.  Epidemiology and transmission of HIV-2. Why there is no HIV-2 pandemic. , 1993, JAMA.

[72]  B. Korber,et al.  Diversity of V3 region sequences of human immunodeficiency viruses type 1 from the central African Republic. , 1993, AIDS research and human retroviruses.

[73]  H. Gayle,et al.  HIV‐1 infection in young men in northern Thailand , 1993, AIDS.

[74]  N. Dubin,et al.  Heterosexual transmission of HIV in a cohort of couples in New York City , 1993, AIDS.

[75]  D. Burke,et al.  Phylogenetic analysis of gag genes from 70 international HIV‐1 isolates provides evidence for multiple genotypes , 1993, AIDS.

[76]  H. Gayle,et al.  Independent introduction of two major HIV-1 genotypes into distinct high-risk populations in Thailand , 1993, The Lancet.

[77]  H. Gayle,et al.  Highly specific V3 peptide enzyme immunoassay for seretyping HIV‐1 specimens from Thailand , 1993, AIDS.

[78]  J. Albert,et al.  Autologous neutralizing antibodies prevail in HIV-2 but not in HIV-1 infection. , 1993, Virology.

[79]  M. Becker,et al.  HIV-1 strains from India are highly divergent from prototypic African and US/European strains, but are linked to a South African isolate. , 1993, AIDS.

[80]  D. Hume,et al.  Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria. , 1993, Immunology.

[81]  J. Goudsmit,et al.  Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution , 1992, Journal of virology.

[82]  H. von Briesen,et al.  HIV-1 and HIV-2 infections in a high-risk population in Bombay, India: evidence for the spread of HIV-2 and presence of a divergent HIV-1 subtype. , 1992, Journal of acquired immune deficiency syndromes.

[83]  P. Piot,et al.  Genetic comparison of HIV-1 isolates from Africa, Europe, and North America. , 1992, AIDS research and human retroviruses.

[84]  R. May,et al.  The spread of HIV-1 in Africa: sexual contact patterns and the predicted demographic impact of AIDS , 1991, Nature.

[85]  A. Cliff,et al.  The spread of human immunodeficiency virus type 2 into Europe: a geographical analysis. , 1991, International journal of epidemiology.

[86]  P. Sawanpanyalert,et al.  SHORT COMMUNICATION: Risk factors for HIV among prostitutes in Chiangmai, Thailand , 1991, AIDS.

[87]  Peter Piot,et al.  HIV infection and sexually transmitted diseases. , 1991 .

[88]  M. Laga,et al.  The interrelationship of sexually transmitted diseases and HIV infection: implications for the control of both epidemics in Africa. , 1991, AIDS.

[89]  T. O'Brien,et al.  HIV-2 infection in an American. , 1991, AIDS.

[90]  K. Ungchusak,et al.  The epidemiology of HIV infection and AIDS in Thailand. , 1991, AIDS.

[91]  T. Ryder,et al.  Rapid and quantitative detection of enzymatically amplified HIV-1 DNA using chemiluminescent oligonucleotide probes. , 1990, AIDS research and human retroviruses.

[92]  S. Hassig,et al.  Heterosexual transmission of HIV-1 among employees and their spouses at two large businesses in Zaire. , 1990, AIDS.

[93]  P. Kissinger,et al.  Transmission of HIV‐1 infections from mothers to infants in Haiti. Impact on childhood mortality and malnutrition , 1990, JAMA.

[94]  I. Eramova,et al.  Outbreak of hospital infection caused by human immunodeficiency virus (HIV) in Elista. , 1990 .

[95]  T. Quinn,et al.  AIDS in the Americas. , 1990, Neonatal network : NN.

[96]  H. Gayle,et al.  PREVALENCE OF AND MORTALITY FROM HIV TYPE 2 IN GUINEA BISSAU, WEST AFRICA , 1989, The Lancet.

[97]  P. Piot,et al.  The prevalence of infection with human immunodeficiency virus over a 10-year period in rural Zaire. , 1988, The New England journal of medicine.

[98]  R. Greenblatt,et al.  Genital ulceration as a risk factor for human immunodeficiency virus infection. , 1988, AIDS.

[99]  L. Braathen,et al.  LANGERHANS CELLS AS PRIMARY TARGET CELLS FOR HIV INFECTION , 1987, The Lancet.

[100]  P Piot,et al.  AIDS virus infection in Nairobi prostitutes. Spread of the epidemic to East Africa. , 1986, The New England journal of medicine.

[101]  J. Pape,et al.  The acquired immunodeficiency syndrome in Haiti. , 1985 .

[102]  J. Chermann,et al.  Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). , 1983, Science.

[103]  T. A. Hagan,et al.  Detection , Isolation , and Continuous Production of Cytopathic Retroviruses ( HTLV-III ) from Patients with AIDS and Pre-AIDS , 2022 .