Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats
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M. Wellner | F. Luft | R. Dechend | D. Müller | E. Shagdarsuren | S. Meiners | A. Fiebeler | P. Gratze | A. Danser | I. Garrelds | D. Feldman | R. Webb | B. Pilz
[1] M. Wellner,et al. Cardiac gene expression profile in rats with terminal heart failure and cachexia. , 2005, Physiological genomics.
[2] J. Ménard,et al. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats , 2005, Journal of hypertension.
[3] F. Luft,et al. Aldosterone Potentiates Angiotensin II–Induced Signaling in Vascular Smooth Muscle Cells , 2004, Circulation.
[4] M. Wellner,et al. A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury. , 2004, The American journal of pathology.
[5] M. Wellner,et al. A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury. , 2004, The American journal of pathology.
[6] A. Stanton,et al. Blood Pressure Lowering in Essential Hypertension With an Oral Renin Inhibitor, Aliskiren , 2003, Hypertension.
[7] Alice Stanton,et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. , 2003, Biochemical and biophysical research communications.
[8] M. Zenke,et al. Immunosuppressive treatment protects against angiotensin II-induced renal damage. , 2002, The American journal of pathology.
[9] N. Hollenberg. Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100). Comparison with enalapril. , 2002, Current hypertension reports.
[10] T. Hammond,et al. Ang II Accumulation in Rat Renal Endosomes During Ang II-Induced Hypertension: Role of AT1 Receptor , 2002, Hypertension.
[11] Dirk,et al. Intrarenal angiotensin II: interstitial and cellular levels and site of production. , 2001, Kidney international.
[12] D. Ganten,et al. Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. , 2000, The American journal of pathology.
[13] L. Mazzolai,et al. Increased cardiac angiotensin II levels induce right and left ventricular hypertrophy in normotensive mice. , 2000, Hypertension.
[14] D. Ganten,et al. Blood pressure-independent effects in rats with human renin and angiotensinogen genes. , 2000, Hypertension.
[15] D. Ganten,et al. Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin and angiotensinogen genes. , 1999, Journal of the American Society of Nephrology : JASN.
[16] D. Ganten,et al. Hypertension-induced end-organ damage : A new transgenic approach to an old problem. , 1999, Hypertension.
[17] N. Hollenberg,et al. Pathways for angiotensin II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. , 1998, Hypertension.
[18] A. Danser,et al. Angiotensin production by the heart: a quantitative study in pigs with the use of radiolabeled angiotensin infusions. , 1998, Circulation.
[19] A. Danser,et al. Angiotensin II type 1 (AT1) receptor-mediated accumulation of angiotensin II in tissues and its intracellular half-life in vivo. , 1997, Hypertension.
[20] J. Ménard,et al. High human renin hypertension in transgenic rats. , 1997, Hypertension.
[21] D. Campbell,et al. Effects of Losartan on Angiotensin and Bradykinin Peptides and Angiotensin‐Converting Enzyme , 1995, Journal of cardiovascular pharmacology.
[22] J. Clozel,et al. Comparative effects of three different potent renin inhibitors in primates. , 1993, Hypertension.
[23] A. Fukamizu,et al. Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. , 1993, The Journal of biological chemistry.
[24] D. Ganten,et al. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[25] D. Ron,et al. A family of constitutive C/EBP‐like DNA binding proteins attenuate the IL‐1 alpha induced, NF kappa B mediated trans‐activation of the angiotensinogen gene acute‐phase response element. , 1990, The EMBO journal.
[26] J. Wood,et al. Effects of a specific and long-acting renin inhibitor in the marmoset. , 1985, Hypertension.
[27] D W Cushman,et al. Enzymes of the renin-angiotensin system and their inhibitors. , 1982, Annual review of biochemistry.
[28] W F Ganong,et al. The renin-angiotensin system. , 1978, Annual review of physiology.