Synthesis of 4,7,8a,9‐tetrahydro‐3H‐diimidazo‐[1,5‐a:4′,5′‐d]pyridine derivatives

The synthesis and evaluation of new ligands for the H3 receptor of histamine is described. These new compounds are diimidazopyridine derivatives readily prepared by a condensation reaction of spinacine and isocyanates.

[1]  R. Leurs,et al.  Therapeutic potential of histamine H3 receptor agonists and antagonists. , 1998, Trends in pharmacological sciences.

[2]  H. Haas,et al.  International Union of Pharmacology. XIII. Classification of histamine receptors. , 1997, Pharmacological reviews.

[3]  H. Stark,et al.  DEVELOPMENTS OF HISTAMINE H3-RECEPTOR ANTAGONISTS , 1996 .

[4]  N. Martín,et al.  Synthesis of tetrahydroimidazo[1,5-b]-β-carboline derivatives with complex basic substituents , 1994 .

[5]  B. Malinowska,et al.  Modulation of neurotransmitter release via histamine H3 heteroreceptors , 1994, Fundamental & clinical pharmacology.

[6]  M. D. R. Rico-Ferreira,et al.  The Pictet-Spengler reaction on L-histidine. Preparation of conformationally restricted (+)-pilocarpine analogs , 1993 .

[7]  O. Zuiderveld,et al.  A simple and rapid in vitro test system for the screening of histamine H3 ligands. , 1992, Methods and findings in experimental and clinical pharmacology.

[8]  G. Klebe,et al.  One-pot synthesis of a 2-dialkylaminoalkyl-substituted tetrahydro-β-carboline-hydantoin system , 1992 .

[9]  C. J. Blankley,et al.  4,5,6,7‐Tetrahydro‐1H‐imidazo[4,5‐c]pyridine‐6‐carboxylic acids (spinacines) , 1991 .

[10]  M. Braña,et al.  Synthesis and Reactivity of β-Carboline-Hydantoin Systems , 1990 .

[11]  M. Braña,et al.  Reaction of 5-hydroxy-L-tryptophan with alkyl isocyanates , 1987 .

[12]  J. Schwartz,et al.  Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors , 1987, Neuroscience.

[13]  J. Schwartz,et al.  Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor , 1983, Nature.

[14]  W. Benz,et al.  Darstellung von Isocyanaten , 1961 .