Deconvolution‐based assessment of pituitary GH secretion stimulated with GHRH+arginine in Prader‐Willi adults and obese controls

The assessment of GH deficiency in adult patients with Prader‐Willi syndrome (PWS) has been previously assessed through the evaluation of quantitative parameters, such as the peak value of GH response to exogenous stimuli. A comprehensive description of the pattern of secretory response obtainable by deconvolution analysis is still lacking. The aim of our study was to characterize the time evolution of responses of PWS subjects compared with obese controls.

[1]  Diego Liberati,et al.  An improved computational method to assess pituitary responsiveness to secretagogue stimuli. , 2002, European journal of endocrinology.

[2]  G. Brabant,et al.  GH/IGF-I Regulation in Obesity – Mechanisms and Practical Consequences in Children and Adults , 2010, Hormone Research in Paediatrics.

[3]  D Liberati,et al.  Non‐parametric deconvolution provides an objective assessment of GH responsiveness to GH‐releasing stimuli in normal subjects , 1997, Clinical endocrinology.

[4]  J. Twisk,et al.  The GH/IGF-I Axis and Pituitary Function and Size in Adults with Prader-Willi Syndrome , 2011, Hormone Research in Paediatrics.

[5]  A. Goldstone.  The hypothalamus, hormones, and hunger: alterations in human obesity and illness. , 2006, Progress in brain research.

[6]  D Liberati,et al.  LH and FSH secretory responses to GnRH in normal individuals: a non-parametric deconvolution approach. , 1999, European journal of endocrinology.

[7]  A. Salvatoni,et al.  Assessment of central adrenal insufficiency in children and adolescents with Prader–Willi syndrome , 2012, Clinical endocrinology.

[8]  A. Holland,et al.  Population prevalence and estimated birth incidence and mortality rate for people with Prader-Willi syndrome in one UK Health Region. , 2001, Journal of medical genetics.

[9]  P. Marzullo,et al.  Impairment of GH responsiveness to combined GH‐releasing hormone and arginine administration in adult patients with Prader‐Willi syndrome , 2006, Clinical endocrinology.

[10]  P. Marzullo,et al.  The impact of growth hormone/insulin-like growth factor-I axis and nocturnal breathing disorders on cardiovascular features of adult patients with Prader-Willi syndrome. , 2005, The Journal of clinical endocrinology and metabolism.

[11]  M. Thorén,et al.  Metabolic profile and body composition in adults with Prader-Willi syndrome and severe obesity. , 2002, The Journal of clinical endocrinology and metabolism.

[12]  Diego Liberati,et al.  Stimulated Secretion of Pituitary Hormones in Normal Humans: A Novel Direct Assessment from Blood Concentrations , 2000, Annals of Biomedical Engineering.

[13]  M. Butler,et al.  Prader–Willi syndrome: clinical genetics, cytogenetics and molecular biology , 2005, Expert Reviews in Molecular Medicine.

[14]  M L Johnson,et al.  The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[15]  D. Swaab,et al.  Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases. , 1995, The Journal of clinical endocrinology and metabolism.

[16]  P. Burman,et al.  Endocrine dysfunction in Prader-Willi syndrome: a review with special reference to GH. , 2001, Endocrine reviews.

[17]  G. Grugni,et al.  Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome , 2008, European Journal of Pediatrics.

[18]  P. Marzullo,et al.  Body fat excess and stimulated growth hormone levels in adult patients with Prader–Willi syndrome , 2009, American journal of medical genetics. Part A.

[19]  Anthony P. Goldstone,et al.  Prader-Willi syndrome: advances in genetics, pathophysiology and treatment , 2004, Trends in Endocrinology & Metabolism.

[20]  E. Spada,et al.  Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr) , 2006, Journal of endocrinological investigation.

[21]  D. J. Driscoll,et al.  Intracranial abnormalities detected by three‐dimensional magnetic resonance imaging in Prader–Willi syndrome , 2007, American journal of medical genetics. Part A.

[22]  P. Marzullo,et al.  Growth hormone secretion among adult patients with Prader-Willi syndrome due to different genetic subtypes , 2011, Journal of endocrinological investigation.

[23]  D. J. Driscoll,et al.  Prader-Willi syndrome. , 1984, Current problems in pediatrics.

[24]  A. Lenzi,et al.  Multiple forms of hypogonadism of central, peripheral or combined origin in males with Prader–Willi syndrome , 2012, Clinical endocrinology.