Size Affects the Stability of the Photoacoustic Conversion of Gold Nanorods

Gold nanorods exhibit intense optical absorption bands in the near-infrared region of principal interest for applications in biomedical optics, which originate from sharp plasmon resonances. This high absorbance, combined with the biochemical inertness and targetability of gold nanoparticles, makes these materials excellent candidates to provide contrast in photoacoustic imaging and for other applications such as the selective hyperthermia of cancer. One issue demoting the potential of gold nanorods as contrast agents in photoacoustic applications is their limited photostability, which falls below relevant permissible exposure limits. In particular, when gold nanorods are resonantly excited by laser pulses in the nanosecond duration regime, there may occur phenomena like reshaping into rounder nanoparticles as well as fragmentation and sublimation, which modify their optical absorption bands and hinder their efficiency of photoacoustic conversion. Here we investigate the influence of nanoparticle size on ...

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