Three-dimensional reconstruction of the human central sulcus reveals a morphological correlate of the hand area.

One way to improve our understanding of cortical anatomy is to visualize the three-dimensional (3D) shape of the cerebral sulci which is normally hidden. Here, we reconstructed the 3D morphology of the central sulcus (CS) in 17 normal subjects, using conventional magnetic resonance images and dedicated software. We found that the 3D morphology was remarkably consistent in all central sulci. Our analyses revealed three different regions (upper, middle and lower), which were easily identifiable by morphological criteria and sharply interconnected in the reconstructed CS. These morphological regions appear to have a strong functional significance, since the middle region corresponded precisely to the 'hand area', as verified by hand vibration positron emission tomography activation studies in eight cases. These data suggest that the 3D anatomy of the cerebral cortex may facilitate sulcal recognition, and sulcal subdivision into smaller morphological elements, bearing remarkable relationships with functional cortical maps.

[1]  J. Dejerine.  Anatomie des centres nerveux , 1895 .

[2]  W. Penfield,et al.  SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION , 1937 .

[3]  Paul Chauchard,et al.  Le cerveau humain , 1963 .

[4]  M. Mintun,et al.  A Noninvasive Approach to Quantitative Functional Brain Mapping with H215O and Positron Emission Tomography , 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[5]  M. Raichle,et al.  Mapping human somatosensory cortex with positron emission tomography. , 1987, Journal of neurosurgery.

[6]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[7]  B. Kolb,et al.  The Cerebral cortex of the rat , 1990 .

[8]  Alan C. Evans,et al.  Attention modulates somatosensory cerebral blood flow response to vibrotactile stimulation as measured by positron emission tomography , 1991, Annals of neurology.

[9]  O Levrier,et al.  Location of hand function in the sensorimotor cortex: MR and functional correlation. , 1994, AJNR. American journal of neuroradiology.

[10]  Y. Samson,et al.  Movement‐ and task‐related activations of motor cortical areas: A positron emission tomographic study , 1994, Annals of neurology.

[11]  J. Régis.  Anatomie sulcale profonde et cartographie fonctionnelle du cortex cerebral , 1994 .

[12]  Isabelle Bloch,et al.  Fast Nonsupervised 3D Registration of PET and MR Images of the Brain , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[13]  H A Drury,et al.  Computational methods for reconstructing and unfolding the cerebral cortex. , 1995, Cerebral cortex.

[14]  J. Régis,et al.  Generic model for the localization of the cerebral cortex and preoperative multimodal integration in epilepsy surgery. , 1995, Stereotactic and functional neurosurgery.

[15]  H. Damasio.  Human Brain Anatomy in Computerized Images , 1995 .

[16]  J. Donoghue,et al.  Shared neural substrates controlling hand movements in human motor cortex. , 1995, Science.

[17]  M. Reiser,et al.  The central sulcal vein: a landmark for identification of the central sulcus using functional magnetic resonance imaging. , 1996, Journal of neurosurgery.

[18]  H. Alkadhi,et al.  Localization of the motor hand area to a knob on the precentral gyrus. A new landmark. , 1997, Brain : a journal of neurology.