Normalization of a spatially variant image reconstruction problem in electrical impedance tomography using system blurring properties

The electrical impedance tomography (EIT) image reconstruction problem is ill posed and spatially variant. Because of the problem's ill-posed nature, small amounts of measurement noise can corrupt reconstructed images. The problem must be regularized to reduce image artifacts. In this paper, we focus on the spatially variant characteristics of the problem. Correcting errors due to spatial variance should improve reconstruction accuracy. In this paper, we present methods to normalize the spatially variant image reconstruction problem by equalizing the point spread function (PSF). In order to equalize the PSF, we used the reconstruction blurring properties obtained from the sensitivity matrix. We compared three mathematical normalization schemes: pixel-wise scaling (PWS), weighted pseudo-inversion (WPI) and weighted minimum norm method (WMNM) to equalize images. The quantity index (QI), defined as the integral of pixel values of an EIT conductivity image, was considered in investigating spatial variance. The QI values along with reconstructed images are presented for cases of two-dimensional full array and hemiarray electrode topologies. We found that a spatially invariant QI could be obtained by applying normalization methods based on equalization of the PSF using conventional regularized reconstruction methods such as truncated singular value decomposition (TSVD) and WMNM. We found that WMNM normalization applied to WMNM regularized reconstruction was the best of the methods tested overall, for both hemiarray and full array electrode topologies.

[1]  Robert Plonsey,et al.  Bioelectromagnetism: Principles and Applications of Bioelectric and Biomagnetic Fields , 1995 .

[2]  R J Sadleir,et al.  Imaging and quantification of anomaly volume using an eight-electrode ‘hemiarray’ EIT reconstruction method , 2008, Physiological measurement.

[3]  P. Hansen The truncatedSVD as a method for regularization , 1987 .

[4]  Andy Adler,et al.  Electrical impedance tomography: regularized imaging and contrast detection , 1996, IEEE Trans. Medical Imaging.

[5]  Gene H. Golub,et al.  Singular value decomposition and least squares solutions , 1970, Milestones in Matrix Computation.

[6]  I. Sutherland,et al.  Correction of the non-uniform spatial sensitivity of electrical impedance tomography images. , 1994, Physiological measurement.

[7]  A Adler,et al.  Monitoring changes in lung air and liquid volumes with electrical impedance tomography. , 1997, Journal of applied physiology.

[8]  B. Brown,et al.  Applied potential tomography: possible clinical applications. , 1985, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[9]  Per Christian Hansen,et al.  Analysis of Discrete Ill-Posed Problems by Means of the L-Curve , 1992, SIAM Rev..

[10]  R. Sadleir,et al.  Quantification of blood volume by electrical impedance tomography using a tissue-equivalent phantom. , 1998, Physiological measurement.

[11]  B H Blott,et al.  The dependence of EIT images on the assumed initial conductivity distribution: a study of pelvic imaging. , 1995, Physics in medicine and biology.

[12]  Te Tang,et al.  A Portable 8-electrode EIT Measurement System , 2007 .

[13]  Yves Goussard,et al.  Regularized reconstruction in electrical impedance tomography using a variance uniformization constraint , 1997, IEEE Transactions on Medical Imaging.

[14]  William R B Lionheart EIT reconstruction algorithms: pitfalls, challenges and recent developments. , 2004, Physiological measurement.

[15]  B H Blott,et al.  High fidelity imaging and high performance computing in nonlinear EIT. , 2000, Physiological measurement.

[16]  Thomas C. Ferrée,et al.  Weighted regularization in electrical impedance tomography with applications to acute cerebral stroke , 2002, IEEE Transactions on Medical Imaging.

[17]  D C Barber,et al.  Quantification in impedance imaging. , 1990, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.