Current developments in 3D bioprinting for tissue engineering

Abstract The field of 3-dimensional (3D) bioprinting has enjoyed rapid development in the past few years for the applications in tissue engineering and regenerative medicine. In this review, we summarize the most updated developments in 3D bioprinting for the applications in tissue engineering with a focus on the printable biomaterials used as bioinks. These developments include 1) novel printing regimes have been enabled by the use of fugitive inks for the creation of intricate structures e.g. vascularized tissue constructs; 2) mechanical strength of printed constructs can be enhanced by co-printing soft and hard biomaterials; 3) bioprinted in-vitro models for drug testing applications are closer to reality. We conclude that the research and application of new bioinks will remain the key highlights of the future developments in 3D bioprinting for tissue engineering.

[1]  James J. Yoo,et al.  A 3D bioprinting system to produce human-scale tissue constructs with structural integrity , 2016, Nature Biotechnology.

[2]  Brendon M. Baker,et al.  Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues , 2012 .

[3]  Xiaoxia Tang,et al.  Effect of pH on the interfacial viscoelasticity and stability of the silk fibroin at the oil/water interface , 2015 .

[4]  Jason A Inzana,et al.  3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. , 2014, Biomaterials.

[5]  Thomas J. Hinton,et al.  3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding , 2016, ACS biomaterials science & engineering.

[6]  Bin Duan,et al.  State-of-the-Art Review of 3D Bioprinting for Cardiovascular Tissue Engineering , 2016, Annals of Biomedical Engineering.

[7]  Jos Malda,et al.  Reinforcement of hydrogels using three-dimensionally printed microfibres , 2015, Nature Communications.

[8]  David L Kaplan,et al.  Polyol-Silk Bioink Formulations as Two-Part Room-Temperature Curable Materials for 3D Printing. , 2015, ACS biomaterials science & engineering.

[9]  Ibrahim T. Ozbolat,et al.  Application areas of 3D bioprinting. , 2016, Drug discovery today.

[10]  Yihua Loo,et al.  Peptide Bioink: Self-Assembling Nanofibrous Scaffolds for Three-Dimensional Organotypic Cultures. , 2015, Nano letters.

[11]  Ying Mei,et al.  Development of peptide-functionalized synthetic hydrogel microarrays for stem cell and tissue engineering applications. , 2016, Acta biomaterialia.

[12]  R. Soares,et al.  Designing Biomaterials for 3D Printing. , 2016, ACS biomaterials science & engineering.

[13]  M. Oyen,et al.  Strong and tough nanofibrous hydrogel composites based on biomimetic principles. , 2017, Materials science & engineering. C, Materials for biological applications.

[14]  Anthony Atala,et al.  Biomaterials for Integration with 3-D Bioprinting , 2014, Annals of Biomedical Engineering.

[15]  Yong Huang,et al.  Freeform drop-on-demand laser printing of 3D alginate and cellular constructs , 2015, Biofabrication.

[16]  T. Scheibel,et al.  Biofabrication of cell-loaded 3D spider silk constructs. , 2015, Angewandte Chemie.

[17]  Jean J. Zhao,et al.  Bioprinting for cancer research. , 2015, Trends in biotechnology.

[18]  Ying Mei,et al.  3D Bioprinting for Vascularized Tissue Fabrication , 2016, Annals of Biomedical Engineering.

[19]  Xuan Zhou,et al.  3D Bioprinting a Cell-Laden Bone Matrix for Breast Cancer Metastasis Study. , 2016, ACS applied materials & interfaces.

[20]  D. Kelly,et al.  A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage , 2016, Biofabrication.

[21]  Liliang Ouyang,et al.  Three-dimensional printing of Hela cells for cervical tumor model in vitro , 2014, Biofabrication.

[22]  Ibrahim T. Ozbolat,et al.  In Vitro Study of Directly Bioprinted Perfusable Vasculature Conduits. , 2015, Biomaterials science.

[23]  Dongsheng Liu,et al.  Rapid formation of a supramolecular polypeptide-DNA hydrogel for in situ three-dimensional multilayer bioprinting. , 2015, Angewandte Chemie.

[24]  Thomas Scheibel,et al.  Biofabrication of 3D constructs: fabrication technologies and spider silk proteins as bioinks , 2015 .

[25]  Xiaofeng Cui,et al.  Inkjet-bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging. , 2015, Biotechnology journal.

[26]  Matt Baker,et al.  Patterning Vasculature: The Role of Biofabrication to Achieve an Integrated Multicellular Ecosystem. , 2016, ACS biomaterials science & engineering.

[27]  T. Singer,et al.  Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro , 2016, PloS one.

[28]  J. Lewis,et al.  Omnidirectional Printing of 3D Microvascular Networks , 2011, Advanced materials.

[29]  Yu-Qing Zhang,et al.  Processing silk hydrogel and its applications in biomedical materials , 2015, Biotechnology progress.

[30]  Kai-Ming Chan,et al.  From the printer: Potential of three-dimensional printing for orthopaedic applications , 2016, Journal of orthopaedic translation.

[31]  Bahattin Koc,et al.  3D bioprinting of biomimetic aortic vascular constructs with self‐supporting cells , 2015, Biotechnology and bioengineering.

[32]  Wenmiao Shu,et al.  Three-dimensional bioprinting of complex cell laden alginate hydrogel structures , 2015, Biofabrication.

[33]  Walter L Murfee,et al.  Printing cancer cells into intact microvascular networks: a model for investigating cancer cell dynamics during angiogenesis. , 2015, Integrative biology : quantitative biosciences from nano to macro.

[34]  Nupura S. Bhise,et al.  A liver-on-a-chip platform with bioprinted hepatic spheroids , 2016, Biofabrication.

[35]  Ibrahim T. Ozbolat,et al.  Bioprinting for vascular and vascularized tissue biofabrication. , 2017, Acta biomaterialia.

[36]  Y. Li,et al.  Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting , 2016, Proceedings of the National Academy of Sciences.

[37]  J. Lewis,et al.  3D Bioprinting of Vascularized, Heterogeneous Cell‐Laden Tissue Constructs , 2014, Advanced materials.

[38]  Dong-Woo Cho,et al.  Three-dimensional bioprinting of cell-laden constructs with polycaprolactone protective layers for using various thermoplastic polymers , 2016, Biofabrication.

[39]  D. Maniglio,et al.  Silk Hydrogels of Tunable Structure and Viscoelastic Properties Using Different Chronological Orders of Genipin and Physical Cross-Linking. , 2015, ACS applied materials & interfaces.

[40]  Mark A. Skylar-Scott,et al.  Three-dimensional bioprinting of thick vascularized tissues , 2016, Proceedings of the National Academy of Sciences.

[41]  E. Jabbari,et al.  Comparative effect of physicomechanical and biomolecular cues on zone-specific chondrogenic differentiation of mesenchymal stem cells. , 2016, Biomaterials.

[42]  B. Zuo,et al.  Novel two-step method to form silk fibroin fibrous hydrogel. , 2016, Materials science & engineering. C, Materials for biological applications.

[43]  Alan Faulkner-Jones,et al.  Bioprinting of human pluripotent stem cells and their directed differentiation into hepatocyte-like cells for the generation of mini-livers in 3D , 2015, Biofabrication.

[44]  Dong-Woo Cho,et al.  Bioprintable, cell-laden silk fibroin-gelatin hydrogel supporting multilineage differentiation of stem cells for fabrication of three-dimensional tissue constructs. , 2015, Acta biomaterialia.

[45]  Alberto Saiani,et al.  3D cell bioprinting of self-assembling peptide-based hydrogels , 2017 .

[46]  C. Anderson.  The continuing evolution. , 2001, Family process.

[47]  D. Kaplan,et al.  Immuno-Informed 3D Silk Biomaterials for Tailoring Biological Responses. , 2016, ACS applied materials & interfaces.

[48]  J. Lewis,et al.  Chaotic mixing in three-dimensional microvascular networks fabricated by direct-write assembly , 2003, Nature materials.

[49]  S. Yoo,et al.  Generation of 3-D glioblastoma-vascular niche using 3-D bioprinting , 2015, 2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC).

[50]  David Williams,et al.  The continuing evolution of biomaterials. , 2011, Biomaterials.

[51]  H. Fischer,et al.  Three-dimensional printing of stem cell-laden hydrogels submerged in a hydrophobic high-density fluid , 2012, Biofabrication.

[52]  Yihua Loo,et al.  Bioprinting synthetic self-assembling peptide hydrogels for biomedical applications , 2015, Biomedical materials.

[53]  Ali Khademhosseini,et al.  Bioprinting the Cancer Microenvironment. , 2016, ACS biomaterials science & engineering.

[54]  Sang-Hyug Park,et al.  Advances in three-dimensional bioprinting for hard tissue engineering , 2016, Tissue Engineering and Regenerative Medicine.

[55]  Jun Fan,et al.  3D Bioprinting Technologies for Hard Tissue and Organ Engineering , 2016, Materials.

[56]  Sophie C Cox,et al.  3D printing of porous hydroxyapatite scaffolds intended for use in bone tissue engineering applications. , 2015, Materials science & engineering. C, Materials for biological applications.

[57]  Sonia Kapoor,et al.  Silk protein-based hydrogels: Promising advanced materials for biomedical applications. , 2016, Acta biomaterialia.

[58]  Ibrahim T. Ozbolat,et al.  Application areas of 3 D bioprinting , 2016 .

[59]  A. Khademhosseini,et al.  Ultrastrong and Flexible Hybrid Hydrogels based on Solution Self-Assembly of Chitin Nanofibers in Gelatin Methacryloyl (GelMA). , 2016, Journal of materials chemistry. B.

[60]  Joon Hyung Park,et al.  Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels , 2015, Science Advances.

[61]  Dong-Woo Cho,et al.  One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology. , 2016, Lab on a chip.

[62]  Seung-Schik Yoo,et al.  Generation of Multi-scale Vascular Network System Within 3D Hydrogel Using 3D Bio-printing Technology , 2014, Cellular and molecular bioengineering.

[63]  Yang Song,et al.  Osteogenic Differentiation of Three-Dimensional Bioprinted Constructs Consisting of Human Adipose-Derived Stem Cells In Vitro and In Vivo , 2016, PloS one.

[64]  Ali Khademhosseini,et al.  Direct 3D bioprinting of perfusable vascular constructs using a blend bioink. , 2016, Biomaterials.

[65]  Ali Khademhosseini,et al.  3D Bioprinting for Tissue and Organ Fabrication , 2016, Annals of Biomedical Engineering.