Failure to deplete anti‐Galα1‐3Gal antibodies after pig‐to‐baboon organ xenotransplantation by immunoaffinity columns containing multiple Galα1‐3Gal oligosaccharides

Abstract:  Background:  The impact of anti‐Galα1‐3Gal (αGal) antibodies on the acute humoral xenograft rejection (AHXR) of pig organs transplanted in baboons is unclear.

[1]  H. Schuurman,et al.  Pathology of xenograft rejection: a commentary , 2003, Xenotransplantation.

[2]  H. Schuurman,et al.  Serum anti-pig antibodies as potential indicators of acute humoral xenograft rejection in pig-to-cynomolgus monkey kidney transplantation , 2002, Transplantation.

[3]  R. Colvin,et al.  Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. , 2001, Transplantation.

[4]  R. Mañez,et al.  Removal of bowel aerobic gram‐negative bacteria is more effective than immunosuppression with cyclophosphamide and steroids to decrease natural α‐Galactosyl IgG antibodies , 2001, Xenotransplantation.

[5]  J. Platt,et al.  Immune complex formation after xenotransplantation : evidence of type III as well as type II immune reactions provide clues to pathophysiology. , 2001, The American journal of pathology.

[6]  J. Platt,et al.  The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts. , 2000, Transplantation.

[7]  P. Veira,et al.  Augmented anti-alphaGalactosyl antibodies in adult baboons in the setting of intestinal parasitic infections are not associated with higher titers of anti-pig hemolytic antibody. , 2000, Transplantation proceedings.

[8]  D. Sachs,et al.  Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti‐Gal antibody: experience with 320 aphereses in baboons , 2000, Xenotransplantation.

[9]  T. Sablinski,et al.  Acute Humoral Xenograft Rejection: Destruction of the Microvascular Capillary Endothelium in Pig-to-Nonhuman Primate Renal Grafts , 2000, Laboratory Investigation.

[10]  D. Adams,et al.  Technique for heterotopic pig heart xenotransplantation in primates. , 1999, The Annals of thoracic surgery.

[11]  W. Mckane,et al.  Polymorphism in the human anti-pig natural antibody repertoire: implications for antigen-specific immunoadsorption. , 1998, Transplantation.

[12]  M. Goddard,et al.  Orthotopic heart transplantation in a transgenic pig-to-primate model. , 1998, Transplantation.

[13]  P. Friend,et al.  Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors. , 1998, Transplantation.

[14]  R. Bollinger,et al.  The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. , 1998, The Journal of clinical investigation.

[15]  T. Sablinski,et al.  Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column. , 1998, Transplantation.

[16]  T. Starzl,et al.  Effect of anticomplement agent K76 COOH on hamster-to-rat and guinea pig-to-rat heart xenotransplantation. , 1996, Transplantation.

[17]  J. Fryer,et al.  Removal Of Baboon And Human Antiporcine Igg And Igm Natural Antibodies By Immunoadsorption: Results of In Vitro And In Vivo Studies , 1995, Transplantation.

[18]  J. Platt,et al.  POLYREACTIVITY AND ANTIGEN SPECIFICITY OF HUMAN XENOREACTIVE MONOCLONAL AND SERUM NATURAL ANTIBODIES , 1991, Transplantation.