Studies on taste masking of levocetrizine di hydrochloride using ion - exchange resins

Levocetrizine Di Hydrochloride is second generation piperazine derivative, a potent H1 selective anti histaminic or anti- allergic agent.It has bitter taste. So, the taste has to be masked inorder to reduce its bitterness, to increase its palatability and to improve patient compliance. The purpose of this research work to prepare tasteless complexes of levocetrizine di hydrochloride with Kyron, a cationic ion - exchange resin, to evaluate bitterness and invitro drug release from the Drug- Resin complex (DRC). Here, DRC was prepared by Batch method using Kyron T 104 and Kyron T- 114 and was found that percentage of drug bound to resin was more with Kyron T -114 and selected it for preparing DRC using ratios from 1:1 to 1:3 and it was founded that 1:3 as the optimized one. The optimized complex was characterized by FT- IR Spectroscopy. Finally , in this work, the effect of various parameters like, stirring time,soaking time,temperature, P H on drug loading efficiency were studied and optimized.The in-vitro drug release studies were also carried out and recorded .Finally ,the bitterness evaluation was performed by involving the volunteers who have rated drug resin complexes as tasteless and agreeable.