Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases.

[1]  Sangeeta Khare,et al.  Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition) , 2016 .

[2]  Xiao Yang,et al.  Mammalian target of rapamycin inhibitor rapamycin enhances anti‐leukemia effect of imatinib on Ph+ acute lymphoblastic leukemia cells , 2014, European journal of haematology.

[3]  J. Dick,et al.  Defining Functional Heterogeneity In Acute Lymphoblastic Leukemia , 2013 .

[4]  Mel Greaves,et al.  Acute lymphoblastic leukaemia , 2013, The Lancet.

[5]  Robert Clarke,et al.  Guidelines for the use and interpretation of assays for monitoring autophagy , 2012 .

[6]  C. Pui.  Recent research advances in childhood acute lymphoblastic leukemia. , 2010, Journal of the Formosan Medical Association = Taiwan yi zhi.

[7]  James D. Johnson,et al.  Autophagy Regulates Pancreatic Beta Cell Death in Response to Pdx1 Deficiency and Nutrient Deprivation* , 2009, The Journal of Biological Chemistry.

[8]  D. Sabatini,et al.  Rapamycin inhibits mTORC1, but not completely , 2009, Autophagy.

[9]  Ashutosh Kumar Singh,et al.  A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1* , 2009, The Journal of Biological Chemistry.

[10]  J. McCubrey,et al.  Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia. , 2009, Cancer research.

[11]  S. Jeha.  New therapeutic strategies in acute lymphoblastic leukemia. , 2009, Seminars in hematology.

[12]  M. Loh,et al.  Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study , 2008, Leukemia.

[13]  Ying Zhao,et al.  Vitamin D3 Induces Autophagy of Human Myeloid Leukemia Cells* , 2008, Journal of Biological Chemistry.

[14]  Yanmin Zhao,et al.  Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition , 2008, Acta Pharmacologica Sinica.

[15]  Leslie L Robison,et al.  Acute lymphoblastic leukaemia , 2018, Radiopaedia.org.

[16]  C. Pui,et al.  New therapeutic strategies for the treatment of acute lymphoblastic leukaemia , 2007, Nature Reviews Drug Discovery.

[17]  V. Poggi,et al.  Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells. , 2005, Blood.

[18]  M. O’Donnell,et al.  Cellular DNA replicases: components and dynamics at the replication fork. , 2005, Annual review of biochemistry.

[19]  G. Laurent,et al.  Antileukemic activity of rapamycin in acute myeloid leukemia. , 2005, Blood.

[20]  S. Hunger,et al.  Childhood leukemia--new advances and challenges. , 2004, The New England journal of medicine.

[21]  Daniel J Klionsky,et al.  Development by self-digestion: molecular mechanisms and biological functions of autophagy. , 2004, Developmental cell.

[22]  V. Brown,et al.  Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Donna Neuberg,et al.  Center B Cells Using Cdna Arrays Gene Expression Profiling of Follicular Lymphoma and Normal Germinal , 2002 .

[24]  S. Emr,et al.  Autophagy as a regulated pathway of cellular degradation. , 2000, Science.

[25]  G. Tomlinson,et al.  Grading of late effects in young adult survivors of childhood cancer followed in an ambulatory adult setting , 2000, Cancer.

[26]  E. Davie,et al.  Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[27]  A T Look,et al.  The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. , 1991, Genes & development.

[28]  M. Cleary,et al.  The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. , 1991, Blood.

[29]  F. Behm,et al.  Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19). , 1990, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[30]  Jonathan J. Shuster,et al.  Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study , 1990 .

[31]  R. Parmley,et al.  Pre-B cell leukemia associated with chromosome translocation 1;19. , 1984, Blood.

[32]  C. Alvarado,et al.  Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes , 1982 .

[33]  M. Cooper,et al.  Pre-B-cell leukemia. A new phenotype of childhood lymphoblastic leukemia. , 1978, The New England journal of medicine.