Effects of oxygen breathing on the heart rate, blood pressure, and cardiac index of normal men--resting, with reactive hyperemia, and after atropine.

Oxygen breathing has been used extensively to treat a wide variety of clinical disorders. An understanding of its effects on the normal circulation, at rest and under conditions of increased cardiac output, is fundamental to the understanding of the efficacy of oxygen therapy in clinical situations. Furthermore, interpretation of physiologic data concerning the effects of hyperoxia on the regional circulations requires definition of any changes in cardiac output or over-all peripheral circulation that occur during oxygen breathing. This investigation was undertaken for two purposes: 1) to evaluate the effects of oxygen breathing on the heart rate, systemic blood pressure, and cardiac index of normal men, resting, after atropine, and subjected to the circulatory stress of reactive hyperemia; and 2) to study the higher ranges of oxygen-sensitive chemoreceptor activity in man.

[1]  H. Swan,et al.  Effect of Breathing Oxygen on Pulmonary Artery Pressure and Pulmonary Vascular Resistance in Patients with Ventricular Septal Defect , 1961, Circulation.

[2]  E. Wood,et al.  Cardiac output and related measurements and pressure values in the right heart and associated vessels, together with an analysis of the hemo-dynamic response to the inhalation of high oxygen mixtures in healthy subjects. , 1958, The Journal of laboratory and clinical medicine.

[3]  H. Bartels,et al.  [Effect of arterial carbon dioxide pressure on chemoreceptor action potentials in the carotid sinus nerves]. , 1955, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere.

[4]  N. Taylor,et al.  HANDBOOK OF PEDIATRICS , 1955, The Ulster Medical Journal.

[5]  E. Asmussen,et al.  The cardiac output in rest and work at low and high oxygen pressures. , 1955, Acta physiologica Scandinavica.

[6]  J. Bean,et al.  Cardiac changes induced by O2, at high pressure, CO2 and low O2, as manifest by the electrocardiogram. , 1952, The American journal of physiology.

[7]  A. Alveryd,et al.  Cardiovascular and respiratory changes in man during oxygen breathing. , 1948, Acta physiologica Scandinavica.

[8]  E. A. Stead,et al.  Cardiac output in man; an analysis of the mechanisms varying the cardiac output based on recent clinical studies. , 1947, Archives of internal medicine.

[9]  J. H. Comroe,et al.  The effect of the inhalation of high and low oxygen concentrations on respiration, pulse rate, ballistocardiogram and arterial oxygen saturation (oximeter) of normal individuals. , 1947, The American journal of physiology.

[10]  W. O. Fenn,et al.  Ballistocardiographic study of changes in cardiac output due to respiration. , 1946, The Journal of clinical investigation.

[11]  F. A. Hitchcock,et al.  The cardiovascular responses to the breathing of 100 per cent oxygen at normal barometric pressure. , 1946, The American journal of physiology.

[12]  A. Keys,et al.  RESPONSES IN SIZE, OUTPUT AND EFFICIENCY OF THE HUMAN HEART TO ACUTE ALTERATION IN THE COMPOSITION OF INSPIRED AIR , 1943 .

[13]  Y. Zotterman,et al.  The Excitation Mechanism of the Chemoreceptors of the Carotid Body , 1940 .

[14]  W. F. Hamilton,et al.  STUDIES ON THE CIRCULATION , 1932 .

[15]  W. F. Hamilton,et al.  STUDIES ON THE CIRCULATION: I. Injection Method: Physical and Mathematical Considerations , 1929 .

[16]  J. Haldane,et al.  The effects of respiration of oxygen on breathing and circulation , 1921, The Journal of physiology.

[17]  J. Parkinson.  The effect of inhalation of oxygen on the rate of the pulse in health , 1912, The Journal of physiology.

[18]  F. G. Benedict,et al.  EFFECTS ON MEN AT REST OF BREATHING OXYGEN-RICH GAS MIXTURES , 1911 .