In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR
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Rasmus Agren | Peng Wang | A. F. Stewart | A. Johansson | Dominika Tworus | O. Andersson | Nadja Schulz | L. Alonso | P. Charbord | Rohit B. Sharma | Lipeng Ren | Lianhe Chu | J. Charbord | Laura C. Alonso | Olov Andersson
[1] D. Yabe,et al. Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model , 2020, iScience.
[2] L. Alonso,et al. Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells , 2020, The Journal of Biological Chemistry.
[3] N. Shrestha,et al. Endoplasmic Reticulum Protein Quality Control in β Cells. , 2020, Seminars in cell & developmental biology.
[4] P. MacDonald,et al. GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration , 2020, Science Translational Medicine.
[5] Fabian J Theis,et al. Generalizing RNA velocity to transient cell states through dynamical modeling , 2019, Nature Biotechnology.
[6] L. Alonso,et al. Atf6α impacts cell number by influencing survival, death and proliferation , 2019, Molecular metabolism.
[7] C. Hutchins,et al. Anabolic and Pro-metabolic Functions of CREB-CRTC in Skeletal Muscle: Advantages and Obstacles for Type 2 Diabetes and Cancer Cachexia , 2019, Front. Endocrinol..
[8] Fabian J Theis,et al. Current best practices in single‐cell RNA‐seq analysis: a tutorial , 2019, Molecular systems biology.
[9] Bao-lan Sun,et al. The role of ORMDL3/ATF6 in compensated beta cell proliferation during early diabetes , 2019, Aging.
[10] Yvan Saeys,et al. A comparison of single-cell trajectory inference methods , 2019, Nature Biotechnology.
[11] Fabian J Theis,et al. PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells , 2019, Genome Biology.
[12] C. Argmann,et al. Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells. , 2019, Cell metabolism.
[13] J. Kelly,et al. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis , 2019, Nature Communications.
[14] C. Dieterich,et al. ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb , 2019, Circulation research.
[15] K. Sakamoto,et al. The Salt-Inducible Kinases: Emerging Metabolic Regulators , 2018, Trends in Endocrinology & Metabolism.
[16] H. Huopio,et al. Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes , 2018, eLife.
[17] Y. Dor,et al. Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse , 2018, eLife.
[18] R. Xavier,et al. Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential , 2018, Trends in Endocrinology & Metabolism.
[19] Erik Sundström,et al. RNA velocity of single cells , 2018, Nature.
[20] Jinrang Kim,et al. Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response , 2018, Diabetes.
[21] D. Melton,et al. Pancreas regeneration , 2018, Nature.
[22] Jin Seo,et al. ER Stress Activates the TOR Pathway through Atf6 , 2018, Journal of molecular signaling.
[23] H. Bengtsson,et al. Replication confers β cell immaturity , 2018, Nature Communications.
[24] Y. Kido,et al. mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells. , 2017, Cell metabolism.
[25] C. Cohrs,et al. Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis , 2017, Molecular metabolism.
[26] Francesca Mulas,et al. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation. , 2017, Cell metabolism.
[27] Andrea C. Carrano,et al. Advances in β cell replacement and regeneration strategies for treating diabetes. , 2016, The Journal of clinical investigation.
[28] Steven J Brown,et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation , 2016, eLife.
[29] Olle Korsgren,et al. Identification of proliferative and mature β-cells in the islets of Langerhans , 2016, Nature.
[30] R. Xavier,et al. Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. , 2016, ACS chemical biology.
[31] S. Itzkovitz,et al. The Genetic Program of Pancreatic β-Cell Replication In Vivo , 2016, Diabetes.
[32] P. MacDonald,et al. Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore. , 2016, Endocrinology.
[33] Randal J. Kaufman,et al. Protein misfolding in the endoplasmic reticulum as a conduit to human disease , 2016, Nature.
[34] J. Ferrer,et al. Can Insulin Production Suppress β Cell Growth? , 2016, Cell metabolism.
[35] Richard D. Smith,et al. SerpinB1 Promotes Pancreatic β Cell Proliferation. , 2016, Cell metabolism.
[36] James D. Johnson,et al. Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation. , 2016, Cell metabolism.
[37] K. Rajendran,et al. Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity , 2015, Molecular metabolism.
[38] Austin D. Swafford,et al. Inhibition of DYRK1A and GSK3B induces human β-cell proliferation , 2015, Nature Communications.
[39] P. Reynolds,et al. Insulin demand regulates β cell number via the unfolded protein response. , 2015, The Journal of clinical investigation.
[40] Sarah A Teichmann,et al. Computational assignment of cell-cycle stage from single-cell transcriptome data. , 2015, Methods.
[41] S. Horvath,et al. Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells , 2015, Cell.
[42] Rohit N. Kulkarni,et al. Human β-Cell Proliferation and Intracellular Signaling: Part 3 , 2015, Diabetes.
[43] Young-sil Yoon,et al. Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells , 2015, Diabetes.
[44] P. Wang,et al. Diabetes mellitus—advances and challenges in human β-cell proliferation , 2015, Nature Reviews Endocrinology.
[45] Peng Wang,et al. Induction of human pancreatic beta cell replication by inhibitors of dual specificity tyrosine regulated kinase , 2015, Nature Medicine.
[46] D. Stainier,et al. Whole Organism High Content Screening Identifies Stimulators of Pancreatic Beta-Cell Proliferation , 2014, PloS one.
[47] K. Kaestner,et al. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver , 2014, Nature Communications.
[48] W. Jia,et al. The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells , 2014, Cell Research.
[49] R. Scharfmann,et al. Development of a conditionally immortalized human pancreatic β cell line. , 2014, The Journal of clinical investigation.
[50] A. Gingras,et al. Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation , 2014, Nature Cell Biology.
[51] A. F. Stewart,et al. Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map , 2014, Diabetes.
[52] Åsa K. Björklund,et al. Full-length RNA-seq from single cells using Smart-seq2 , 2014, Nature Protocols.
[53] D. Mathis,et al. Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes , 2013, Science Translational Medicine.
[54] D. Stainier,et al. Metabolic Regulation of Cellular Plasticity in the Pancreas , 2013, Current Biology.
[55] R. Screaton,et al. CRTC2 is required for β-cell function and proliferation. , 2013, Endocrinology.
[56] M. Lung,et al. Subcellular Fractionation of Cultured Human Cell Lines , 2013 .
[57] Lisa M. Ryno,et al. Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. , 2013, Cell reports.
[58] J. Kushner. The role of aging upon β cell turnover. , 2013, The Journal of clinical investigation.
[59] Patrick G. A. Pedrioli,et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages , 2012, Proceedings of the National Academy of Sciences.
[60] F. R. Papa,et al. Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes. , 2012, Cold Spring Harbor perspectives in medicine.
[61] Y. Dor,et al. Pancreatic Beta Cells in Very Old Mice Retain Capacity for Compensatory Proliferation* , 2012, The Journal of Biological Chemistry.
[62] Ryan M. Anderson,et al. Adenosine signaling promotes regeneration of pancreatic β cells in vivo. , 2012, Cell metabolism.
[63] L. Elghazi,et al. mTORC1 signaling and regulation of pancreatic β-cell mass , 2012, Cell cycle.
[64] C. Hetz. The unfolded protein response: controlling cell fate decisions under ER stress and beyond , 2012, Nature Reviews Molecular Cell Biology.
[65] M. Montminy,et al. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals , 2011, Nature Reviews Molecular Cell Biology.
[66] Eric T. Wang,et al. An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data , 2009, PLoS Comput. Biol..
[67] M. Montminy,et al. The CREB Coactivator CRTC2 Links Hepatic ER Stress and Fasting Gluconeogenesis , 2009, Nature.
[68] R. Rizza,et al. β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans , 2008, Diabetes.
[69] Atsushi Miyawaki,et al. Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression , 2008, Cell.
[70] H. Yoshida,et al. Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1 , 2007 .
[71] Ryan M. Anderson,et al. Conditional targeted cell ablation in zebrafish: A new tool for regeneration studies , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.
[72] Michael J. Parsons,et al. Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase , 2007, Mechanisms of Development.
[73] F. Wondisford,et al. Increased Pancreatic β-Cell Proliferation Mediated by CREB Binding Protein Gene Activation , 2006, Molecular and Cellular Biology.
[74] M. Hall,et al. TOR Signaling in Growth and Metabolism , 2006, Cell.
[75] M. Montminy,et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism , 2005, Nature.
[76] J. Kushner,et al. Very Slow Turnover of β-Cells in Aged Adult Mice , 2005 .
[77] R. Kaufman,et al. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. , 2004, Journal of biochemistry.
[78] Douglas A. Melton,et al. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation , 2004, Nature.
[79] J. Joly,et al. I-SceI meganuclease mediates highly efficient transgenesis in fish , 2002, Mechanisms of Development.
[80] M. Azim,et al. Glycoprotein synthesis and inhibition of glycosylation by tunicamycin in preimplantation mouse embryos: Compaction and trophoblast adhesion , 1979, Cell.
[81] A. Harada,et al. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. , 2008, Cell structure and function.
[82] Xianrang Song,et al. Maturation of a central , 1996 .