FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells.

[1]  Z. Xia,et al.  Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2‐related programmed cell death in an AMPK‐dependent manner , 2020, Journal of cellular and molecular medicine.

[2]  Stephen A. Sastra,et al.  Cysteine depletion induces pancreatic tumor ferroptosis in mice , 2020, Science.

[3]  Jitendra Kumar Meena,et al.  Energy stress-mediated AMPK activation inhibits ferroptosis , 2020, Nature Cell Biology.

[4]  D. Krysko,et al.  Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion , 2019, Nature Reviews Cancer.

[5]  X. Ao,et al.  Molecular mechanisms of ferroptosis and its role in cancer therapy , 2019, Journal of cellular and molecular medicine.

[6]  T. Vanden Berghe,et al.  Targeting Ferroptosis to Iron Out Cancer. , 2019, Cancer cell.

[7]  A. Chinnaiyan,et al.  CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy , 2019, Nature.

[8]  W. Fan,et al.  DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin , 2019, Free radical biology & medicine.

[9]  Wei Li,et al.  BAP1 links metabolic regulation of ferroptosis to tumor suppression , 2018, Nature Cell Biology.

[10]  D. Klionsky,et al.  AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity , 2018, Current Biology.

[11]  G. J. Yoshida Comment on “Targeting AMPK, mTOR and β-Catenin by Combined Metformin and Aspirin Therapy in HCC: An Appraisal in Egyptian HCC Patients” , 2018, Molecular Diagnosis & Therapy.

[12]  R. Shaw,et al.  AMPK: guardian of metabolism and mitochondrial homeostasis , 2017, Nature Reviews Molecular Cell Biology.

[13]  B. Stockwell,et al.  Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease , 2017, Cell.

[14]  C. Chiu,et al.  FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism , 2017, Scientific Reports.

[15]  G. J. Yoshida Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment , 2017, Journal of Hematology & Oncology.

[16]  Q. Pan,et al.  Ferroptosis is an autophagic cell death process , 2016, Cell Research.

[17]  M. Lotze,et al.  Autophagy promotes ferroptosis by degradation of ferritin , 2016, Autophagy.

[18]  W. Gu,et al.  Ferroptosis as a p53-mediated activity during tumour suppression , 2015, Nature.

[19]  H. Tseng,et al.  Involvement of vacuolar H+‐ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720 , 2015, Pigment cell & melanoma research.

[20]  A. Walch,et al.  Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice , 2014, Nature Cell Biology.

[21]  Matthew E. Welsch,et al.  Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.

[22]  Han-dong Wang,et al.  FTY720 for cancer therapy (Review). , 2013, Oncology reports.

[23]  D. Perrotti,et al.  Protein phosphatase 2A: a target for anticancer therapy. , 2013, The Lancet. Oncology.

[24]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[25]  Zhuogang Liu,et al.  Autophagy induced by FTY720 promotes apoptosis in U266 cells. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[26]  J. Byrd,et al.  FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death. , 2011, Blood.

[27]  C. Wallington-Beddoe,et al.  FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells , 2011, Autophagy.

[28]  Nicholas H Oberlies,et al.  Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite. , 2011, Journal of natural products.

[29]  Y. Qi,et al.  FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy , 2010, Autophagy.

[30]  V. Janssens,et al.  PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). , 2008, Trends in biochemical sciences.

[31]  Guido Kroemer,et al.  Autophagy in the Pathogenesis of Disease , 2008, Cell.

[32]  M. Ikekita,et al.  A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells , 2003, British journal of pharmacology.

[33]  A. Nairn,et al.  Identification of calmodulin-dependent protein kinase III and its major Mr 100,000 substrate in mammalian tissues. , 1985, Proceedings of the National Academy of Sciences of the United States of America.