Blood substitutes: the future is now.

[1]  H. Harasaki,et al.  In vivo evaluation of a pyridoxylated-hemoglobin-polyoxyethylene conjugate. , 2009, Biomaterials, artificial cells, and artificial organs.

[2]  A. Galán,et al.  Preparations of synthetic phospholipids promote procoagulant activity on damaged vessels: studies under flow conditions , 2008, Transfusion.

[3]  B. Alving.  Potential for synthetic phospholipids as partial platelet substitutes , 2008, Transfusion.

[4]  G. Manley,et al.  Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201. , 2003, The Journal of trauma.

[5]  E. Moore,et al.  The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. , 2002, Journal of the American College of Surgeons.

[6]  E. Frykberg,et al.  Medical management of disasters and mass casualties from terrorist bombings: how can we cope? , 2002, The Journal of trauma.

[7]  J. Holcomb,et al.  The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries. , 2002, The Journal of trauma.

[8]  Irwin Gratz,et al.  Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial. , 2002, The Journal of thoracic and cardiovascular surgery.

[9]  E. Moore,et al.  Increased rate of infection associated with transfusion of old blood after severe injury. , 2002, Archives of surgery.

[10]  C. Ward,et al.  Post hoc mortality analysis on the efficacy trial of diaspirin cross-linked hemoglobin in the treatment of severe traumatic hemorrhagic shock. , 2002, The Journal of trauma.

[11]  C. Weijer,et al.  Lessons from everyday lives: A moral justification for acute care research* , 2002, Critical care medicine.

[12]  P. Holland,et al.  Transfusion-related acute lung injury: report of a clinical look-back investigation. , 2002, JAMA.

[13]  E. Moore,et al.  Blood substitute and erythropoietin therapy in a severely injured Jehovah's witness. , 2002, The New England journal of medicine.

[14]  M. Giovachino,et al.  Modeling the consequences of bioterrorism response. , 2001, Military medicine.

[15]  B. Eiseman.  Combat casualty management for tomorrow's battlefield: urban terrorism. , 2001, The Journal of trauma.

[16]  H. Krumholz,et al.  Blood transfusion in elderly patients with acute myocardial infarction. , 2001, The New England journal of medicine.

[17]  P. Huston,et al.  Withholding proven treatment in clinical research. , 2001, The New England journal of medicine.

[18]  E. Segal,et al.  Recombinant activated factor VII for adjunctive hemorrhage control in trauma. , 2001, The Journal of trauma.

[19]  M. Blajchman,et al.  Novel treatment modalities: new platelet preparations and subsititutes , 2001, British journal of haematology.

[20]  L. Jenkins,et al.  Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism. , 2001, The Journal of trauma.

[21]  E. Moore,et al.  Blood transfusion and the two-insult model of post-injury multiple organ failure. , 2001, Shock.

[22]  E. Moore,et al.  Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreduction. , 2001, The Journal of trauma.

[23]  M. Gladwin,et al.  Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[24]  W. Sibbald,et al.  Hemoglobin solutions—Not just red blood cell substitutes , 2000, Critical care medicine.

[25]  A. Greenburg,et al.  A phase I study of oxidized raffinose cross-linked human hemoglobin , 2000, Critical care medicine.

[26]  J. Mullon,et al.  Transfusions of polymerized bovine hemoglobin in a patient with severe autoimmune hemolytic anemia. , 2000, The New England journal of medicine.

[27]  S. J. McFaul,et al.  Hemoglobin stimulates the release of proinflammatory cytokines from leukocytes in whole blood. , 2000, The Journal of laboratory and clinical medicine.

[28]  Christoff,et al.  Haemodynamic response following a 10% topload infusion of HemolinkTM in conscious, anaesthetized and treated spontaneously hypertensive rats , 2000, Transfusion medicine.

[29]  L. Pearce,et al.  Bovine hemoglobin-based oxygen carrier (HBOC-201) for resuscitation of uncontrolled, exsanguinating liver injury in swine. Carolina Resuscitation Research Group. , 2000, Shock.

[30]  G. LaMuraglia,et al.  The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution. , 2000, Journal of vascular surgery.

[31]  E. Moore,et al.  Age of transfused blood is an independent risk factor for postinjury multiple organ failure. , 1999, American journal of surgery.

[32]  H H Lipowsky,et al.  Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability. , 1999, American journal of physiology. Heart and circulatory physiology.

[33]  D. Gens,et al.  Diaspirin Cross-Linked Hemoglobin (DCLHb) in the Treatment of Severe Traumatic Hemorrhagic Shock: A Randomized Controlled Efficacy Trial , 1999 .

[34]  S. Kirkley.  Proposed Mechanisms of Transfusion-Induced Immunomodulation , 1999, Clinical Diagnostic Laboratory Immunology.

[35]  J. Stamler,et al.  The oxyhemoglobin reaction of nitric oxide. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[36]  E. Moore,et al.  Neutrophils are primed for cytotoxicity and resist apoptosis in injured patients at risk for multiple organ failure. , 1999, Surgery.

[37]  E. Moore,et al.  Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function. , 1999, The Journal of trauma.

[38]  T. Billiar,et al.  Novel roles of nitric oxide in hemorrhagic shock. , 1999, Shock.

[39]  A. Alayash.  Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants? , 1999, Nature Biotechnology.

[40]  J. Loscalzo,et al.  O-raffinose cross-linking markedly reduces systemic and renal vasoconstrictor effects of unmodified human hemoglobin. , 1999, The Journal of pharmacology and experimental therapeutics.

[41]  E. Moore,et al.  Resuscitation of the injured patient with polymerized stroma-free hemoglobin does not produce systemic or pulmonary hypertension. , 1998, American journal of surgery.

[42]  E. Moore,et al.  The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. , 1998, Journal of the American College of Surgeons.

[43]  E. Moore,et al.  Circulating postinjury neutrophils are primed for the release of proinflammatory cytokines. , 1998, The Journal of trauma.

[44]  A. Greenburg,et al.  Cell-free hemoglobin preserves renal function during normothermic ischemia. , 1998, The Journal of surgical research.

[45]  K. Vandegriff,et al.  Arterial Blood Pressure Responses to Cell-free Hemoglobin Solutions and the Reaction with Nitric Oxide* , 1998, The Journal of Biological Chemistry.

[46]  N. Voelkel,et al.  Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. , 1998, The Journal of clinical investigation.

[47]  J. Schulte am Esch,et al.  Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection. , 1998, British journal of anaesthesia.

[48]  C. Hsia,et al.  Respiratory function of hemoglobin. , 1998, The New England journal of medicine.

[49]  R. Weiskopf,et al.  Human cardiovascular and metabolic response to acute, severe isovolemic anemia. , 1998, JAMA.

[50]  J. Stamler,et al.  Reactions between nitric oxide and haemoglobin under physiological conditions , 1998, Nature.

[51]  B. Wittenberg,et al.  A first evaluation of the natural high molecular weight polymeric Lumbricus terrestris hemoglobin as an oxygen carrier. , 1997, Artificial cells, blood substitutes, and immobilization biotechnology.

[52]  A. Bodenham,et al.  Initial evaluation of diaspirin cross-linked hemoglobin (DCLHb) as a vasopressor in critically ill patients. , 1997, Critical care medicine.

[53]  E. Moore,et al.  Clinical utility of human polymerized hemoglobin as a blood substitute after acute trauma and urgent surgery. , 1997, The Journal of trauma.

[54]  A. Gulati,et al.  Role of ET and NO in resuscitative effect of diaspirin cross-linked hemoglobin after hemorrhage in rat. , 1997, The American journal of physiology.

[55]  M. Remberger,et al.  Generation of cytokines in red cell concentrates during storage is prevented by prestorage white cell reduction , 1997, Transfusion.

[56]  A. Paterson,et al.  The association of biologically active lipids with the development of transfusion‐related acute lung injury: a retrospective study , 1997, Transfusion.

[57]  I. T. Demchenko,et al.  Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. , 1997, Science.

[58]  A. Sauaia,et al.  Blood Transfusion: An Independent Risk Factor for Postinjury Multiple Organ Failure , 1997 .

[59]  W. Sibbald,et al.  Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats. , 1997, Critical care medicine.

[60]  G. Kramer,et al.  Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes. , 1997, The Journal of trauma.

[61]  J. Schulte am Esch,et al.  Bovine hemoglobin increases skeletal muscle oxygenation during 95% artificial arterial stenosis. , 1997, Surgery.

[62]  S. Cohn,et al.  Resuscitation of pulmonary contusion: effects of a red cell substitute. , 1997, Critical care medicine.

[63]  K. Werdan,et al.  Impaired energy metabolism in septic hearts of baboons: diminished activities of complex I and complex II of the mitochondrial respiratory chain: 95 , 1997 .

[64]  E. Moore,et al.  Human Polymerized Hemoglobin As A Blood Substitute Avoids Transfusion‐Induced PMN Priming For Superoxide and Elastase Release: 582 , 1997 .

[65]  J. Siegel,et al.  Use of recombinant hemoglobin solution in reversing lethal hemorrhagic hypovolemic oxygen debt shock. , 1997, The Journal of trauma.

[66]  H. Nielsen,et al.  Time‐dependent, spontaneous release of white cell‐ and platelet‐derived bioactive substances from stored human blood , 1996, Transfusion.

[67]  G. Moss,et al.  Clinical Development of Human Polymerized Hemoglobin as a Blood Substitute , 1996, World Journal of Surgery.

[68]  W. Buzello,et al.  Effects of a Hemoglobin-Based Oxygen Carrier (HBOC-201) on Hemodynamics and Oxygen Transport in Patients Undergoing Preoperative Hemodilution for Elective Abdominal Aortic Surgery , 1996, Anesthesia and analgesia.

[69]  R. Waxweiler,et al.  Physical injuries and fatalities resulting from the Oklahoma City bombing. , 1996, JAMA.

[70]  J. Schulte am Esch,et al.  Bovine haemoglobin is more potent than autologous red blood cells in restoring muscular tissue oxygenation after profound isovolaemic haemodilution in dogs , 1996, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[71]  S. Kleinman,et al.  The Risk of Transfusion-Transmitted Viral Infections , 1996 .

[72]  G. S. Hughes,et al.  Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. , 1996, Critical care medicine.

[73]  Andrew D. Rosenberg,et al.  Practice Guidelines for Blood Component Therapy: A Report by the American Society of Anesthesiologists Task Force on Blood Component Therapy , 1996, Anesthesiology.

[74]  C. Schultz,et al.  A medical disaster response to reduce immediate mortality after an earthquake. , 1996, The New England journal of medicine.

[75]  R. Winslow.  Blood substitutes — a moving target , 1995, Nature Medicine.

[76]  E. Moore,et al.  Postinjury neutrophil priming and activation: an early vulnerable window. , 1995, Surgery.

[77]  G. Vlahakes,et al.  Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions. , 1995, Journal of applied physiology.

[78]  E. Moore,et al.  Postinjury neutrophil priming and activation states: therapeutic challenges. , 1995, Shock.

[79]  G. Moss,et al.  The development of hemoglobin solutions as red cell substitutes: hemoglobin solutions. , 1995, Transfusion science.

[80]  C. Silliman,et al.  Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase. , 1994, The Journal of laboratory and clinical medicine.

[81]  N. Heddle,et al.  Biologic effects of leukocytes present in transfused cellular blood products , 1994 .

[82]  J. Fratantoni.  Points to consider on efficacy evaluation of hemoglobin‐ and perfluorocarbon‐based oxygen carriers. Center for Biologics Evaluation and Research , 1994, Transfusion.

[83]  A S Rudolph,et al.  Lyophilized liposome encapsulated hemoglobin: Evaluation of hemodynamic, biochemical, and hematologic responses , 1994, Critical care medicine.

[84]  K. van Ackern,et al.  EFFECTS OF STROMA‐FREE HEMOGLOBIN SOLUTIONS ON PULMONARY VASCULAR RESISTANCE AND MEDIATOR RELEASE IN THE ISOLATED PERFUSED RABBIT LUNG , 1994, Shock.

[85]  K. Burhop,et al.  A role for endothelin and nitric oxide in the pressor response to diaspirin cross-linked hemoglobin. , 1993, The Journal of laboratory and clinical medicine.

[86]  W J Sibbald,et al.  Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. , 1993, JAMA.

[87]  J. Hess,et al.  Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. , 1993, Journal of applied physiology.

[88]  C. Cayten,et al.  Blood transfusion increases the risk of infection after trauma. , 1993, Archives of surgery.

[89]  K. Nagai,et al.  A human recombinant haemoglobin designed for use as a blood substitute , 1992, Nature.

[90]  J. Fratantoni.  Points to consider in the safety evaluation of hemoglobin‐based oxygen carriers , 1991, Transfusion.

[91]  Malcolm Ds,et al.  Cross-linked hemoglobin solution as a resuscitative fluid after hemorrhage in the rat. , 1991 .

[92]  B. Walker,et al.  Stiffened erythrocytes augment the pulmonary hemodynamic response to hypoxia. , 1990, Journal of applied physiology.

[93]  G. Feuerstein,et al.  Characterization of hemodynamic, hematologic, and biochemical responses to administration of liposome-encapsulated hemoglobin in the conscious, freely moving rat. , 1989, Circulatory shock.

[94]  A. Mason,et al.  Relationship of transfusion and infection in a burn population , 1988 .

[95]  K. Jan,et al.  Influence of reduced red cell deformability on regional blood flow. , 1987, The American journal of physiology.

[96]  P. Rogers,et al.  Isolation and characterization of a new hemoglobin derivative cross-linked between the alpha chains (lysine 99 alpha 1----lysine 99 alpha 2). , 1986, The Journal of biological chemistry.

[97]  A. Riggs,et al.  Oxygenation properties of hemoglobin from the earthworm, Lumbricus terrestris. Effects of pH, salts, and temperature. , 1986, The Journal of biological chemistry.

[98]  N. Hyman,et al.  Blood transfusions and survival after lung cancer resection. , 1985, American journal of surgery.

[99]  J. Ponsky,et al.  Blood transfusion and disease‐free survival in carcinoma of the breast , 1984, Journal of surgical oncology.

[100]  G. Moss,et al.  Hemoglobin solution--from tetramer to polymer. , 1984, Surgery.

[101]  R. Bellamy.  The causes of death in conventional land warfare: implications for combat casualty care research. , 1984, Military medicine.

[102]  P. Tartter,et al.  EFFECT OF BLOOD TRANSFUSIONS ON COLONIC MALIGNANCY RECURRENCE RATE , 1982, The Lancet.

[103]  P. Barie,et al.  Failure of red blood cell transfusion to increase oxygen transport or mixed venous PO2 in injured patients. , 1982, The Journal of trauma.

[104]  K. Ajisaka,et al.  Modification of human hemoglobin with polyethylene glycol : a new candidate for blood substitute. , 1980, Biochemical and biophysical research communications.

[105]  A. Greenburg,et al.  Intravascular persistence and oxygen delivery of pyridoxalated, stroma-free hemoglobin during gradations of hypotension. , 1979, Surgery.

[106]  J. Arnold,et al.  A clinical safety trial of stroma‐free hemoglobin , 1978, Clinical pharmacology and therapeutics.

[107]  T. Zuck,et al.  Total and Partial Blood Exchange in the Rat with Hemoglobin Prepared by Crystallization , 1977, Transfusion.

[108]  G. Moss,et al.  Stroma-free hemoglobin. I. Preparation and observations on in vitro changes in coagulation. , 1973, Surgery.

[109]  M. R. Mickey,et al.  Effect of blood transfusions on subsequent kidney transplants. , 1973, Transplantation proceedings.

[110]  H. Bunn.  Differences in the Interaction of 2,3-Diphosphoglycerate with Certain Mammalian Hemoglobins , 1971, Science.

[111]  S F Rabiner,et al.  Further Studies with Stroma‐Free Hemoglobin Solution , 1970, Annals of surgery.

[112]  G. Peskin,et al.  Stroma-free hemoglobin solution: the "ideal" blood substitute? , 1969, Surgery.

[113]  J. Helbert,et al.  EVALUATION OF A STROMA-FREE HEMOGLOBIN SOLUTION FOR USE AS A PLASMA EXPANDER , 1967, The Journal of experimental medicine.

[114]  J. L. Brandt,et al.  The effects of hemoglobin solutions on renal functions in man. , 1951, Blood.

[115]  J. H. Miller,et al.  The effect of hemoglobin on renal function in the human. , 1951, The Journal of clinical investigation.

[116]  W. R. Amberson,et al.  Oxygen consumption with hemoglobin-ringer , 1934 .

[117]  W. R. Amberson,et al.  MAMMALIAN LIFE WITHOUT RED BLOOD CORPUSCLES. , 1933, Science.

[118]  A. W. Sellards,et al.  Injection of Hemoglobin in Man and its Relation to Blood Destruction, with especial reference to the Anemias. , 1916, The Journal of medical research.

[119]  E. Moore,et al.  Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute. , 2003, The Journal of trauma.

[120]  E. Deitch,et al.  Influence of storage on red blood cell rheological properties. , 2002, The Journal of surgical research.

[121]  S. Kleinman,et al.  Leukocyte reduction of blood components: public policy and new technology. , 2000, Transfusion medicine reviews.

[122]  E. Vamvakas,et al.  Prestorage versus poststorage white cell reduction for the prevention of the deleterious immunomodulatory effects of allogeneic blood transfusion. , 2000, Transfusion medicine reviews.

[123]  K. Kao.  Mechanisms and new approaches for the allogeneic blood transfusion-induced immunomodulatory effects. , 2000, Transfusion medicine reviews.

[124]  A. Eldad,et al.  Prehospital blood transfusion in prolonged evacuation. , 1999, The Journal of trauma.

[125]  J. D. Hellums,et al.  Oxygen transport by erythrocyte/hemoglobin solution mixtures in an in vitro capillary as a model of hemoglobin-based oxygen carrier performance. , 1998, Microvascular research.

[126]  R. Winslow,et al.  Fluid resuscitation with O2 vs. non-O2 carriers after 2 h of hemorrhagic shock in conscious hamsters. , 1997, The American journal of physiology.

[127]  R Zajtchuk,et al.  Battlefield trauma care: focus on advanced technology. , 1995, Military medicine.

[128]  A. Sauaia,et al.  Early predictors of postinjury multiple organ failure. , 1994, Archives of surgery.

[129]  D. J. Cole,et al.  Nitric Oxide Mediates the Hypertensive Response to a Modified Hemoglobin Solution (DCLHBTH) in Rats , 1994 .

[130]  G. Vlahakes,et al.  Efficacy of a new blood substitute based on ultra-pure polymerized bovine hemoglobulin. A preliminary report. , 1989, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[131]  N. Laird,et al.  Perioperative red blood cell transfusion , 1988 .

[132]  G. Moss,et al.  Large-volume preparation of pyridoxylated hemoglobin with high P50. , 1981, The Journal of surgical research.

[133]  W. R. Amberson,et al.  Clinical experience with hemoglobin-saline solutions. , 1947, Year book - American Philosophical Society.