Cancer chemoprevention based on the epigenetics

DNA methylation is an important part of epigenetics, which includes the interaction with histone modification, the change of the chromatin structure, and the regulation of gene expression. In mammalian cells of human, DNA methylation is closely related to life phenomenon such as cell proliferation, senescence and canceration. Based on DNA methylation, this review summarized recent advances on the role of diet compounds in regulation of epigengtics. Cancer chemoprevention through inhibition of DNA methylation or histone acetylation has also been discussed.

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