Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M.

[1]  W. Paul,et al.  Disrupting Il13 impairs production of IL-4 specified by the linked allele , 2001, Nature Immunology.

[2]  J Wagner,et al.  Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. , 2000, Immunity.

[3]  M. Loh,et al.  Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. , 2000, Molecular cell.

[4]  R. Tarleton,et al.  Increased Susceptibility of Stat4-Deficient and Enhanced Resistance in Stat6-Deficient Mice to Infection with Trypanosoma cruzi1 , 2000, The Journal of Immunology.

[5]  L. Glimcher,et al.  Lineage commitment in the immune system: the T helper lymphocyte grows up. , 2000, Genes & development.

[6]  M. Kaplan,et al.  Cutting Edge: Differential Expression of Chemokines in Th1 and Th2 Cells Is Dependent on Stat6 But Not Stat41 , 2000, The Journal of Immunology.

[7]  C. Perreault,et al.  Regulation of Extrathymic T Cell Development and Turnover by Oncostatin M1 , 2000, The Journal of Immunology.

[8]  U. Schindler,et al.  A Gain-of-function Mutation in STAT6* , 2000, The Journal of Biological Chemistry.

[9]  J. Galon,et al.  Stat4 Is Expressed in Activated Peripheral Blood Monocytes, Dendritic Cells, and Macrophages at Sites of Th1-Mediated Inflammation1 , 2000, The Journal of Immunology.

[10]  Jan Mous,et al.  Touching base , 2000, Nature Genetics.

[11]  H. Broxmeyer,et al.  Abnormal Chemokine-Induced Responses of Immature and Mature Hematopoietic Cells from Motheaten Mice Implicate the Protein Tyrosine Phosphatase Shp-1 in Chemokine Responses , 1999, The Journal of experimental medicine.

[12]  Y. Ito,et al.  Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[13]  K. L. Donaldson,et al.  Regulation of inflammatory responses by oncostatin M. , 1999, Journal of immunology.

[14]  Yoshiaki Ito,et al.  Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer , 1999, The EMBO journal.

[15]  N. Copeland,et al.  Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. , 1999, Blood.

[16]  M. Kaplan,et al.  A Signal Transducer and Activator of  Transcription (Stat)4-independent Pathway for the Development of  T Helper Type 1 Cells , 1998, The Journal of experimental medicine.

[17]  G. McKenzie,et al.  Impaired development of Th2 cells in IL-13-deficient mice. , 1998, Immunity.

[18]  R. Young,et al.  Hematopoietic Remodeling in Interferon-γ–Deficient Mice Infected With Mycobacteria , 1998 .

[19]  M. Wills-Karp,et al.  Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production , 1998, The Journal of experimental medicine.

[20]  G. McKenzie,et al.  A distinct role for interleukin-13 in Th2-cell-mediated immune responses , 1998, Current Biology.

[21]  M. Kaplan,et al.  Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. , 1998, Journal of immunology.

[22]  H. Haugen,et al.  Regulation of an extrathymic T-cell development pathway by oncostatin M , 1996, Nature.

[23]  Kenneth M. Murphy,et al.  Functional diversity of helper T lymphocytes , 1996, Nature.

[24]  P. Doherty,et al.  Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells , 1996, Nature.

[25]  M. Kaplan,et al.  Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.

[26]  T. Mosmann,et al.  Continuous administration of Il-13 to mice induces extramedullary hemopoiesis and monocytosis. , 1996, Journal of immunology.

[27]  S. Akira,et al.  Essential role of Stat6 in IL-4 signalling , 1996, Nature.

[28]  W. Paul,et al.  Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene , 1996, Nature.

[29]  N. Copeland,et al.  Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK‐STAT5 pathway. , 1996, The EMBO journal.

[30]  M. Kaplan,et al.  Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. , 1996, Immunity.

[31]  D. Kioussis,et al.  Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. , 1995, Journal of immunological methods.

[32]  E. Petricoin,et al.  Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[33]  W. Paul,et al.  Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis , 1995, Molecular and cellular biology.

[34]  S. Szabo,et al.  Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4 , 1995, The Journal of experimental medicine.

[35]  H. Haugen,et al.  Developmental abnormalities in mice transgenic for bovine oncostatin M , 1995, Molecular and cellular biology.

[36]  B. Ryffel,et al.  The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo , 1995, The Journal of experimental medicine.

[37]  W. Leonard,et al.  The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. , 1995, Immunity.

[38]  A. Bernad,et al.  Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. , 1994, Immunity.

[39]  S. McKnight,et al.  An interleukin-4-induced transcription factor: IL-4 Stat. , 1994, Science.

[40]  N. Copeland,et al.  Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation , 1994, Molecular and cellular biology.

[41]  J. Darnell,et al.  Stat3 and Stat4: members of the family of signal transducers and activators of transcription. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[42]  E. Smeland,et al.  Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells , 1993, The Journal of experimental medicine.

[43]  H. Broxmeyer,et al.  Clonogenic methods in vitro for the enumeration of granulocyte-macrophage progenitor cells (CFU-GM) in human bone marrow and mouse bone marrow and spleen , 1991 .

[44]  S. Misawa,et al.  Actions of human interleukin-4/B-cell stimulatory factor-1 on proliferation and differentiation of enriched hematopoietic progenitor cells in culture. , 1990, Blood.

[45]  D. Williams,et al.  Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. Multiple actions. , 1988, Journal of immunology.

[46]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[47]  A. Krensky,et al.  Production of colony-stimulating factor(s) for granulocyte-macrophage and multipotential (granulocyte/erythroid/megakaryocyte/macrophage) hematopoietic progenitor cells (CFU-GEMM) by clonal lines of human IL-2-dependent T-lymphocytes. , 1984, Experimental hematology.

[48]  Singh Ap,et al.  Amplification of granulopoiesis by T cell subpopulations. , 1983 .

[49]  W. Paul,et al.  The IL-4 receptor: signaling mechanisms and biologic functions. , 1999, Annual review of immunology.

[50]  R. Borojevic,et al.  Comparative analysis of splenic cell proliferation induced by interleukin 3 and by syngeneic accessory cells (syngeneic mixed leukocyte reaction): evidence that autoreactive T-cell functioning instructs hematopoietic phenomena. , 1990, Cellular immunology.