Conducting polymer-hydrogels for medical electrode applications

Abstract Conducting polymers hold significant promise as electrode coatings; however, they are characterized by inherently poor mechanical properties. Blending or producing layered conducting polymers with other polymer forms, such as hydrogels, has been proposed as an approach to improving these properties. There are many challenges to producing hybrid polymers incorporating conducting polymers and hydrogels, including the fabrication of structures based on two such dissimilar materials and evaluation of the properties of the resulting structures. Although both fabrication and evaluation of structure–property relationships remain challenges, materials comprised of conducting polymers and hydrogels are promising for the next generation of bioactive electrode coatings.

[1]  A. Tiwari,et al.  Electrochemical Synthesis of Chitosan-co-polyaniline/WO3⋅nH2O Composite Electrode for Amperometric Detection of NO2 Gas , 2008 .

[2]  L. M. Lira,et al.  Conducting polymer–hydrogel composites for electrochemical release devices: Synthesis and characterization of semi-interpenetrating polyaniline–polyacrylamide networks , 2005 .

[3]  S. Stauffer,et al.  Poly (vinyl alcohol) hydrogels prepared by freezing-thawing cyclic processing , 1992 .

[4]  A. Gefen,et al.  Are in vivo and in situ brain tissues mechanically similar? , 2004, Journal of biomechanics.

[5]  J. Hetke,et al.  Surface modification of neural recording electrodes with conducting polymer/biomolecule blends. , 2001, Journal of biomedical materials research.

[6]  G. Wallace,et al.  Conducting polymers for neural interfaces: challenges in developing an effective long-term implant. , 2008, Biomaterials.

[7]  Xinyan Tracy Cui,et al.  Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[8]  B. C. Kim,et al.  Electroformation of conducting polymers in a hydrogel support matrix , 2000 .

[9]  David C. Martin,et al.  In vivo studies of polypyrrole/peptide coated neural probes. , 2003, Biomaterials.

[10]  F. Cui,et al.  Culture of neural cells on silicon wafers with nano-scale surface topograph , 2002, Journal of Neuroscience Methods.

[11]  J. Jacobs,et al.  Evaluation of metallic and polymeric biomaterial surface energy and surface roughness characteristics for directed cell adhesion. , 2001, Tissue engineering.

[12]  G. Wallace,et al.  Responsive conducting polymer-hydrogel composites , 1997 .

[13]  W. Hennink,et al.  In situ gelling hydrogels for pharmaceutical and biomedical applications. , 2008, International journal of pharmaceutics.

[14]  Gordon G Wallace,et al.  Promoting neurite outgrowth from spiral ganglion neuron explants using polypyrrole/BDNF-coated electrodes. , 2009, Journal of biomedical materials research. Part A.

[15]  G. Wallace,et al.  Synthesis and properties of a mechanically strong poly(bithiophene) composite polymer containing a polyelectrolyte dopant , 2000 .

[16]  Timothy A. Barbari,et al.  Hydrogel membranes with mesh size asymmetry based on the gradient crosslinking of poly(vinyl alcohol) , 1999 .

[17]  A. Alippi,et al.  Indentation modulus and hardness of viscoelastic thin films by atomic force microscopy: A case study. , 2009, Ultramicroscopy.

[18]  Gordon G Wallace,et al.  Optimising the incorporation and release of a neurotrophic factor using conducting polypyrrole. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[19]  David C. Martin,et al.  Polymerization of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) around living neural cells. , 2007, Biomaterials.

[20]  O. Inganäs,et al.  Composite biomolecule/PEDOT materials for neural electrodes , 2008, Biointerphases.

[21]  David C. Martin,et al.  Fuzzy gold electrodes for lowering impedance and improving adhesion with electrodeposited conducting polymer films , 2003 .

[22]  Mohammad Reza Abidian,et al.  Multifunctional Nanobiomaterials for Neural Interfaces , 2009 .

[23]  J. Dual,et al.  Mechanical characterization of PEDOT : PSS thin films , 2009 .

[24]  Olle Inganäs,et al.  Hydrogels of a conducting conjugated polymer as 3-D enzyme electrode. , 2003, Biosensors & bioelectronics.

[25]  Christine E. Schmidt,et al.  Conducting polymers in biomedical engineering , 2007 .

[26]  Yen Wei,et al.  Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications. , 2006, Biomaterials.

[27]  Hui-yun Sun,et al.  Polyaniline/polyacrylamide conducting composite hydrogel with a porous structure , 2008 .

[28]  Nigel H Lovell,et al.  Cell attachment functionality of bioactive conducting polymers for neural interfaces. , 2009, Biomaterials.

[29]  Brian Culshaw,et al.  Smart Structures and Materials , 2004 .

[30]  Wei Lin,et al.  Preparation and Gel Properties of Poly[hydroxyethylmethacrylate-co-poly(ethylene glycol) methacrylate] Copolymeric Hydrogels by Photopolymerization , 2002 .

[31]  Lihua Na,et al.  Dynamically formed poly (vinyl alcohol) ultrafiltration membranes with good anti-fouling characteristics , 2000 .

[32]  A. Gefen,et al.  Age-dependent changes in material properties of the brain and braincase of the rat. , 2003, Journal of neurotrauma.

[33]  L. M. Lira,et al.  Polymeric electro-mechanic devices applied to antibiotic-controlled release , 2008 .

[34]  Erkki Ruoslahti,et al.  Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule , 1984, Nature.

[35]  W. Hennink,et al.  Dextran hydrogels for the controlled release of proteins , 1997 .

[36]  L. Poole-Warren,et al.  Development of bioactive conducting polymers for neural interfaces , 2010, Expert review of medical devices.

[37]  David C. Martin,et al.  Electrochemical deposition and characterization of poly(3,4-ethylenedioxythiophene) on neural microelectrode arrays , 2003 .

[38]  J. Hubbell,et al.  Water-borne, in situ crosslinked biomaterials from phase-segregated precursors. , 2003, Journal of biomedical materials research. Part A.

[39]  J. Elisseeff,et al.  Advances in skeletal tissue engineering with hydrogels. , 2005, Orthodontics & craniofacial research.

[40]  Gordon G. Wallace,et al.  Electrochemical induced ductile—brittle transition in tosylate-doped (pTS) polypyrrole , 1998 .

[41]  Jianquan Wang,et al.  Swelling behaviors, tensile properties and thermodynamic studies of water sorption of 2-hydroxyethyl methacrylate/epoxy methacrylate copolymeric hydrogels , 2005 .

[42]  D. Kipke,et al.  Open-architecture Neural Probes Reduce Cellular Encapsulation , 2006 .

[43]  Kevin J. Otto,et al.  Poly(3,4-ethylenedioxythiophene) as a Micro-Neural Interface Material for Electrostimulation , 2009, Front. Neuroeng..

[44]  William R. Stauffer,et al.  Polypyrrole doped with 2 peptide sequences from laminin. , 2006, Biomaterials.

[45]  Anthony Guiseppi-Elie,et al.  Electroconductive Hydrogels: Electrical and Electrochemical Properties of Polypyrrole‐Poly(HEMA) Composites , 2005 .

[46]  Elisabeth Smela,et al.  Polyaniline actuators: Part 1. PANI(AMPS) in HCl , 2005 .

[47]  A. Monkman,et al.  Inherently Electrically Conductive Fibers Wet Spun from a Sulfonic Acid–Doped Polyaniline Solution , 1998 .

[48]  Joyce Y Wong,et al.  Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity , 2007, Journal of neural engineering.

[49]  Seon Jeong Kim,et al.  Hydrogel-Assisted Polyaniline Microfiber as Controllable Electrochemical Actuatable Supercapacitor , 2009 .

[50]  J. Vuust,et al.  Adverse Reactions to Injectable Soft Tissue Permanent Fillers , 2005, Aesthetic Plastic Surgery.

[51]  Kytai Truong Nguyen,et al.  Photopolymerizable hydrogels for tissue engineering applications. , 2002, Biomaterials.

[52]  F. MacKintosh,et al.  Scanning probe-based frequency-dependent microrheology of polymer gels and biological cells. , 2000, Physical review letters.

[53]  Anuar Kassim,et al.  Fourier transform infrared study of polypyrrole–poly(vinyl alcohol) conducting polymer composite films: Evidence of film formation and characterization , 2006 .

[54]  P. Flory Principles of polymer chemistry , 1953 .

[55]  S. Cogan,et al.  Retinal prostheses: current challenges and future outlook , 2007, Journal of biomaterials science. Polymer edition.

[56]  David F Meaney,et al.  Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures. , 2006, Biophysical journal.

[57]  Hitoshi Yamato,et al.  Stability of polypyrrole and poly(3,4-ethylenedioxythiophene) for biosensor application , 1995 .

[58]  R Langer,et al.  Stimulation of neurite outgrowth using an electrically conducting polymer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[59]  C. Bowman,et al.  Modifying network chemistry in thiol-acrylate photopolymers through postpolymerization functionalization to control cell-material interactions. , 2008, Journal of biomedical materials research. Part A.

[60]  Jessica O. Winter,et al.  Adhesion Molecule-Modified Biomaterials for Neural Tissue Engineering , 2009, Front. Neuroeng..

[61]  Toribio F. Otero,et al.  Mechanical characterization of free-standing polypyrrole film , 2007 .

[62]  N. Peppas Hydrogels in Medicine and Pharmacy , 1987 .

[63]  Jennifer L West,et al.  Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. , 2005, Biomaterials.

[64]  Lisa A Flanagan,et al.  Neurite branching on deformable substrates , 2002, Neuroreport.

[65]  Gordon G Wallace,et al.  Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons. , 2009, Biomaterials.

[66]  Wim E. Hennink,et al.  Degradation and release behavior of dextran-based hydrogels , 1997 .

[67]  A. Khademhosseini,et al.  Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology , 2006 .

[68]  G. Wallace,et al.  Preparation of hydrogel/conducting polymer composites , 1994 .

[69]  Wendy C. Crone,et al.  Effects of swelling on the mechanical properties of a pH-sensitive hydrogel for use in microfluidic devices , 2004 .

[70]  Nigel H Lovell,et al.  Impact of co-incorporating laminin peptide dopants and neurotrophic growth factors on conducting polymer properties. , 2010, Acta biomaterialia.

[71]  W. Hennink,et al.  Formation of dextran hydrogels by crystallization. , 2001, Biomaterials.

[72]  H. Sheardown,et al.  Adhesion of corneal epithelial cells to cell adhesion peptide modified pHEMA surfaces , 2001, Journal of biomaterials science. Polymer edition.

[73]  C. H. Wang,et al.  Biocompatibility of electroactive polymers in tissues. , 2000, Journal of biomedical materials research.

[74]  G. Wallace,et al.  In-situ mechanical properties of tosylate doped (pts) polypyrrole , 1997 .

[75]  David C. Martin,et al.  Impedance spectroscopy and nanoindentation of conducting poly(3,4-ethylenedioxythiophene) coatings on microfabricated neural prosthetic devices , 2006 .

[76]  C. Bowman,et al.  Mechanical properties of hydrogels and their experimental determination. , 1996, Biomaterials.

[77]  Arthur J. Epstein,et al.  Towards optimization of electrical and mechanical properties of polyaniline: Is crosslinking between chains the key? , 1993 .

[78]  David C. Martin,et al.  Experimental and theoretical characterization of implantable neural microelectrodes modified with conducting polymer nanotubes. , 2008, Biomaterials.

[79]  S. Saeki,et al.  Measurement of stress and strain during tensile testing of gellan gum gels: effect of deformation speed , 2002 .

[80]  D. Hoffman-Kim,et al.  Micropatterns of positive guidance cues anchored to polypyrrole doped with polyglutamic acid: a new platform for characterizing neurite extension in complex environments. , 2006, Biomaterials.

[81]  Jennifer T. Blundo,et al.  Effect of Poly(vinyl alcohol) Macromer Chemistry and Chain Interactions on Hydrogel Mechanical Properties , 2007 .

[82]  L. Poole-Warren,et al.  Structural and functional characterisation of poly(vinyl alcohol) and heparin hydrogels. , 2008, Biomaterials.

[83]  Daryl R Kipke,et al.  Conducting polymers on hydrogel-coated neural electrode provide sensitive neural recordings in auditory cortex. , 2010, Acta biomaterialia.

[84]  David C. Martin,et al.  Surface modification of neural probes with conducting polymer poly(hydroxymethylated-3,4-ethylenedioxythiophene) and its biocompatibility , 2006, Applied biochemistry and biotechnology.

[85]  Jennifer L West,et al.  Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering. , 2002, Biomaterials.

[86]  Natalie Dowell-Mesfin,et al.  Release of nerve growth factor from HEMA hydrogel-coated substrates and its effect on the differentiation of neural cells. , 2009, Biomacromolecules.

[87]  M. Abidian,et al.  Conducting‐Polymer Nanotubes for Controlled Drug Release , 2006, Advanced materials.

[88]  Mehdi Shafieian,et al.  Changes to the viscoelastic properties of brain tissue after traumatic axonal injury. , 2009, Journal of biomechanics.

[89]  J. Hedrick,et al.  Expanding the role of chemistry to produce new amphiphilic polymer (co)networks , 2009 .

[90]  David C. Martin,et al.  Electrochemical polymerization and properties of PEDOT/S-EDOT on neural microelectrode arrays , 2004 .

[91]  David C. Martin,et al.  Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film , 2006, Journal of neural engineering.

[92]  D. Roylance,et al.  Influence of dopant ion and synthesis variables on mechanical properties of polypyrrole films , 1987 .

[93]  Min Kyoon Shin,et al.  A nanofibrous hydrogel templated electrochemical actuator: From single mat to a rolled-up structure , 2009 .

[94]  Jin-Ye Wang,et al.  Characterization of nanostructure and cell compatibility of polyaniline films with different dopant acids. , 2008, The journal of physical chemistry. B.

[95]  Kristi S. Anseth,et al.  Characterization of hydrogels formed from acrylate modified poly(vinyl alcohol) macromers , 2000 .

[96]  Anthony Guiseppi-Elie,et al.  Chemical and Biological Sensors Based on Electrochemical Detection Using Conducting Electroactive Polymers , 2003 .

[97]  Antonios G Mikos,et al.  Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. , 2002, Journal of biomedical materials research.

[98]  S. Bryant,et al.  Influence of ECM proteins and their analogs on cells cultured on 2-D hydrogels for cardiac muscle tissue engineering. , 2009, Acta biomaterialia.

[99]  Robert K. Shepherd,et al.  Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss , 2008, Hearing Research.

[100]  Yun Lu,et al.  Conducting hydrogels with enhanced mechanical strength , 2009 .

[101]  M. Mazur,et al.  Functionalisation of monolayer-modified electrodes by covalent coupling of o-phenylenediamine monomer molecules , 2000 .

[102]  P. Vadgama,et al.  Polypyrrole-based conducting polymers and interactions with biological tissues , 2006, Journal of The Royal Society Interface.

[103]  A. Guiseppi-Elie,et al.  Polypyrrole-hydrogel composites for the construction of clinically important biosensors. , 2002, Biosensors & bioelectronics.

[104]  A. Van de Voorde,et al.  In vitro release characteristics of bioactive molecules from dextran dialdehyde cross-linked gelatin hydrogel films. , 1998, Biomaterials.

[105]  W. Reichert Indwelling Neural Implants : Strategies for Contending with the In Vivo Environment , 2007 .

[106]  P. Pickup,et al.  Ion transport in poly(3,4-ethylenedioxythiophene)–poly(styrene-4-sulfonate) composites , 2000 .

[107]  P. Tresco,et al.  Response of brain tissue to chronically implanted neural electrodes , 2005, Journal of Neuroscience Methods.

[108]  C. Schmidt,et al.  Synthesis and characterization of polypyrrole-hyaluronic acid composite biomaterials for tissue engineering applications. , 2000, Journal of biomedical materials research.

[109]  S. Cogan Neural stimulation and recording electrodes. , 2008, Annual review of biomedical engineering.

[110]  Wilfried Nisch,et al.  Substrate-Integrated Microelectrodes with Improved Charge Transfer Capacity by 3-Dimensional Micro-Fabrication , 2003 .

[111]  Rebecca Kuntz Willits,et al.  Effect of collagen gel stiffness on neurite extension , 2004, Journal of biomaterials science. Polymer edition.

[112]  D. Mooney,et al.  Hydrogels for tissue engineering: scaffold design variables and applications. , 2003, Biomaterials.

[113]  Yuliang Cao,et al.  Poly(vinyl alcohol)/poly(acrylic acid) hydrogel coatings for improving electrode-neural tissue interface. , 2009, Biomaterials.

[114]  D Seliktar,et al.  MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. , 2004, Journal of biomedical materials research. Part A.

[115]  Kwang Min Shin,et al.  Electrochemical actuation in chitosan/polyaniline microfibers for artificial muscles fabricated using an in situ polymerization , 2008 .

[116]  Jennifer L West,et al.  Covalently-Immobilized Vascular Endothelial Growth Factor Promotes Endothelial Cell Tubulogenesis in Poly(ethylene glycol) Diacrylate Hydrogels , 2009, Journal of biomaterials science. Polymer edition.

[117]  Jochen Guck,et al.  Viscoelastic properties of individual glial cells and neurons in the CNS , 2006, Proceedings of the National Academy of Sciences.

[118]  David C. Martin,et al.  Conducting polymers grown in hydrogel scaffolds coated on neural prosthetic devices. , 2004, Journal of biomedical materials research. Part A.

[119]  K. Neoh,et al.  Porous and electrically conductive polypyrrole-poly(vinyl alcohol) composite and its applications as a biomaterial. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[120]  G. Prestwich,et al.  Synthesis and biological evaluation of a cross-linked hyaluronan-mitomycin C hydrogel. , 2004, Biomacromolecules.

[121]  L. M. Lira,et al.  Conducting polymer- hydrogel blends for electrochemically controlled drug release devices , 2008 .

[122]  A. Guiseppi-Elie,et al.  Bio-smart hydrogels: co-joined molecular recognition and signal transduction in biosensor fabrication and drug delivery. , 2002, Biosensors & bioelectronics.

[123]  Wim E. Hennink,et al.  Novel crosslinking methods to design hydrogels , 2002 .

[124]  P. Martens,et al.  Synthesis and characterization of degradable hydrogels formed from acrylate modified poly(vinyl alcohol) macromers , 2002 .

[125]  J. Pinson,et al.  Attachment of Polymers to Organic Moieties Covalently Bonded to Iron Surfaces , 2002 .

[126]  Kenton R Kaufman,et al.  Transversely isotropic tensile material properties of skeletal muscle tissue. , 2010, Journal of the mechanical behavior of biomedical materials.

[127]  R. Gangopadhyay,et al.  Conducting polymer gel : formation of a novel semi-IPN from polyaniline and crosslinked poly(2-acrylamido-2-methyl propanesulphonicacid) , 2005 .

[128]  A. Guiseppi-Elie,et al.  Characterization of electroconductive blends of poly(HEMA-co-PEGMA-co-HMMA-co-SPMA) and poly(Py-co-PyBA). , 2009, Biomacromolecules.

[129]  Lisa N Gillespie,et al.  BDNF‐induced survival of auditory neurons in vivo: Cessation of treatment leads to accelerated loss of survival effects , 2003, Journal of neuroscience research.

[130]  W. Hennink,et al.  Delayed release of a model protein from enzymatically-degrading dextran hydrogels , 1997 .

[131]  F. Lim,et al.  Microencapsulated islets as bioartificial endocrine pancreas. , 1980, Science.

[132]  Kip A Ludwig,et al.  Interfacing Conducting Polymer Nanotubes with the Central Nervous System: Chronic Neural Recording using Poly(3,4‐ethylenedioxythiophene) Nanotubes , 2009, Advanced materials.

[133]  G. Tourillon,et al.  Stability of Conducting Polythiophene and Derivatives , 1983 .

[134]  A. F. Rubira,et al.  Electrochemical and mechanical properties of hydrogels based on conductive poly(3,4-ethylene dioxythiophene)/poly(styrenesulfonate) and PAAm , 2006 .

[135]  Gymama E. Slaughter,et al.  Electrical and electrochemical characterization of electroconductive PPy-p(HEMA) composite hydrogels , 2003, SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring.

[136]  Rachel Z. Pytel,et al.  In situ observation of dynamic elastic modulus in polypyrrole actuators , 2008 .

[137]  W. Meier,et al.  Biomimetic membranes designed from amphiphilic block copolymers. , 2006, Soft matter.

[138]  Stephen O'Leary,et al.  The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons. , 2007, Biomaterials.

[139]  Miriam V. Flores-Merino,et al.  Block copolymer nanostructures , 2008 .

[140]  Francis J. Doyle,et al.  Dynamic Behavior of Glucose-Responsive Poly(methacrylic acid-g-ethylene glycol) Hydrogels , 1997 .

[141]  A. Khokhlov,et al.  Silk-inspired ‘molecular chimeras’: Atomistic simulation of nanoarchitectures based on thiophene peptide copolymers , 2008 .

[142]  Jennifer L West,et al.  Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. , 2005, Tissue engineering.