Combination therapy for hypertension 2013: an update.

We provide a review of recent additions to the antihypertensive armamentarium in the form of combination therapy. These include two-drug and three-drug combinations in a single pill. There is evidence that such combinations are more efficacious than the individual components and that patient adherence to therapy is improved.

[1]  F. Turnbull.  Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials , 2003, The Lancet.

[2]  B. Sherrill,et al.  Single‐Pill vs Free‐Equivalent Combination Therapies for Hypertension: A Meta‐Analysis of Health Care Costs and Adherence , 2011, Journal of clinical hypertension.

[3]  James Brian Byrd,et al.  Combination therapy as initial treatment for newly diagnosed hypertension. , 2011, American heart journal.

[4]  H. Black,et al.  Aliskiren Alone or in Combination With Hydrochlorothiazide in Patients With the Lower Ranges of Stage 2 Hypertension: The ACQUIRE Randomized Double‐Blind Study , 2010, The Journal of Clinical Hypertension.

[5]  Anthony Rodgers,et al.  Blood Pressure and Stroke: An Overview of Published Reviews , 2004, Stroke.

[6]  G. Mancia,et al.  Cardiovascular Protection by Initial and Subsequent Combination of Antihypertensive Drugs in Daily Life Practice , 2011, Hypertension.

[7]  M. Volpe,et al.  Efficacy and Safety of Triple Antihypertensive Therapy with the Olmesartan / Amlodipine / Hydrochlorothiazide Combination , 2012 .

[8]  S. Oparil,et al.  24‐Hour Efficacy and Safety of Triple‐Combination Therapy With Olmesartan, Amlodipine, and Hydrochlorothiazide: The TRINITY Ambulatory Blood Pressure Substudy , 2011, Journal of clinical hypertension.

[9]  J. Blacher,et al.  Effect of a fixed combination of Perindopril and Amlodipine on blood pressure control in 6256 patients with not-at-goal hypertension: the AVANT'AGE study. , 2013, Journal of the American Society of Hypertension : JASH.

[10]  M. Dickson,et al.  Compliance with Antihypertensive Therapy in the Elderly , 2008, American journal of cardiovascular drugs : drugs, devices, and other interventions.

[11]  E. Deeks.  Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide , 2011, Drugs.

[12]  D. Duprez,et al.  Combination Angiotensin‐Receptor Blocker (ARB)/Calcium Channel Blocker With HCTZ vs the Maximal Recommended Dose of an ARB With HCTZ in Patients With Stage 2 Hypertension: The Exforge As Compared to Losartan Treatment in Stage 2 Systolic Hypertension (EXALT) Study , 2011, Journal of clinical hypertension.

[13]  S. Neldam,et al.  Telmisartan and Amlodipine Single‐Pill Combinations vs Amlodipine Monotherapy for Superior Blood Pressure Lowering and Improved Tolerability in Patients With Uncontrolled Hypertension: Results of the TEAMSTA‐5 Study , 2011, Journal of clinical hypertension.

[14]  Anne L. Taylor,et al.  New recommendations for treating hypertension in black patients: evidence and/or consensus? , 2010, Hypertension.

[15]  J. Basile,et al.  Blood Pressure Effects of Combined β‐Blocker and Angiotensin‐Converting Enzyme Inhibitor Therapy Compared With the Individual Agents: A Placebo‐Controlled Study With Nebivolol and Lisinopril , 2012, Journal of clinical hypertension.

[16]  W. Cushman,et al.  Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. , 2012, The American journal of medicine.

[17]  A. Dominiczak,et al.  2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) , 2007, European heart journal.

[18]  J. Izzo,et al.  Olmesartan/amlodipine/hydrochlorothiazide in participants with hypertension and diabetes, chronic kidney disease, or chronic cardiovascular disease: a subanalysis of the multicenter, randomized, double-blind, parallel-group TRINITY study , 2012, Cardiovascular Diabetology.

[19]  S. Oparil,et al.  Triple therapy with olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide in adult patients with hypertension: The TRINITY multicenter, randomized, double-blind, 12-week, parallel-group study. , 2010, Clinical therapeutics.

[20]  D. Calhoun,et al.  24-Hour ambulatory blood pressure control with triple-therapy amlodipine, valsartan and hydrochlorothiazide in patients with moderate to severe hypertension , 2011, Journal of Human Hypertension.

[21]  V. Chair,et al.  Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. , 2014, Stroke.

[22]  Edouard Battegay,et al.  Hypertension: Principles and Practice , 2005 .

[23]  T. Philipp,et al.  Two multicenter, 8-week, randomized, double-blind, placebo-controlled, parallel-group studies evaluating the efficacy and tolerability of amlodipine and valsartan in combination and as monotherapy in adult patients with mild to moderate essential hypertension. , 2007, Clinical therapeutics.

[24]  Irene Katzan,et al.  Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the american heart association/american stroke association. , 2011, Stroke.

[25]  S. Oparil,et al.  Long‐Term Efficacy and Safety of Triple‐Combination Therapy With Olmesartan Medoxomil and Amlodipine Besylate and Hydrochlorothiazide for Hypertension , 2012, Journal of clinical hypertension.

[26]  D. Wald,et al.  Combination Therapy Versus Monotherapy in Reducing Blood Pressure: Meta-analysis on 11,000 Participants from 42 Trials , 2010 .

[27]  N. Poulter,et al.  Compliance, Safety, and Effectiveness of Fixed-Dose Combinations of Antihypertensive Agents: A Meta-Analysis , 2010, Hypertension.

[28]  S. Taddei,et al.  Clinic and ambulatory blood pressure lowering effect of aliskiren/amlodipine/hydrochlorothiazide combination in patients with moderate-to-severe hypertension: a randomized active-controlled trial , 2012, Journal of hypertension.

[29]  Initial combination therapy with amlodipine/valsartan compared with monotherapy in the treatment of hypertension. , 2011, Journal of the American Society of Hypertension : JASH.

[30]  Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. , 1967, JAMA.

[31]  B. Neal.  The Blood Pressure Lowering Treatment Trialists' Collaboration , 2001 .

[32]  Fabian Bamberg,et al.  Noninvasive 24-h ambulatory blood pressure and cardiovascular disease: a systematic review and meta-analysis , 2008, Journal of hypertension.

[33]  Bernard J. Gersh,et al.  Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease: A Scientific Statement From the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention , 2007, Circulation.

[34]  B Neal,et al.  Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials , 2000, The Lancet.

[35]  E. Deeks.  Amlodipine/Valsartan/Hydrochlorothiazide , 2009, American journal of cardiovascular drugs : drugs, devices, and other interventions.

[36]  B. Materson,et al.  Combination therapy in the treatment of hypertension , 2005 .

[37]  K. Ferdinand,et al.  Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension. , 2011, Journal of the American Society of Hypertension : JASH.

[38]  Daniel W. Jones,et al.  The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. , 2003, JAMA.

[39]  B. Materson.  Enhancing Dosage Flexibility in Combination Therapy , 2007, Journal of clinical hypertension.

[40]  J. Neoptolemos,et al.  Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study , 2000, The Lancet.

[41]  Daniel W. Jones,et al.  Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. , 2003, Hypertension.

[42]  D. Duprez,et al.  Ambulatory blood pressure response to triple therapy with an angiotensin-receptor blocker (ARB), calcium-channel blocker (CCB), and HCTZ versus dual therapy with an ARB and HCTZ , 2011, Vascular health and risk management.

[43]  S. Nesbitt,et al.  A Titrate‐to‐Goal Study of Switching Patients Uncontrolled on Antihypertensive Monotherapy to Fixed‐Dose Combinations of Amlodipine and Olmesartan Medoxomil ± Hydrochlorothiazide , 2011, Journal of clinical hypertension.

[44]  D. Calhoun,et al.  Triple Antihypertensive Therapy With Amlodipine, Valsartan, and Hydrochlorothiazide: A Randomized Clinical Trial , 2009, Hypertension.

[45]  S. Yusuf,et al.  Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. , 2000 .

[46]  H. Parise,et al.  Initial Combination Therapy Reduces the Risk of Cardiovascular Events in Hypertensive Patients: A Matched Cohort Study , 2013, Hypertension.

[47]  L. Ruilope,et al.  Efficacy and tolerability of initial therapy with single-pill combination telmisartan/hydrochlorothiazide 80/25 mg in patients with grade 2 or 3 hypertension: a multinational, randomized, double-blind, active-controlled trial. , 2012, Clinical therapeutics.

[48]  G. Bakris,et al.  Combination therapy in hypertension. , 2010, Journal of the American Society of Hypertension : JASH.

[49]  A. Forker,et al.  Comparison of Aliskiren/Hydrochlorothiazide Combination Therapy and Amlodipine Monotherapy in Patients With Stage 2 Systolic Hypertension and Type 2 Diabetes Mellitus , 2011, Journal of clinical hypertension.

[50]  H. Black,et al.  Comparative Efficacy and Safety of Combination Aliskiren/Amlodipine and Amlodipine Monotherapy in African Americans With Stage 2 Hypertension , 2011, Journal of clinical hypertension.

[51]  H. Black,et al.  Single‐Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study , 2012, Journal of clinical hypertension.

[52]  D. Calhoun,et al.  Amlodipine/valsartan/hydrochlorothiazide triple combination therapy in moderate/severe hypertension: Secondary analyses evaluating efficacy and safety , 2009, Advances in therapy.