Neurotrophic factors in Alzheimer’s and Parkinson’s disease brain

[1]  H. Thoenen,et al.  Neurotrophic factors and neuronal death. , 2007, Ciba Foundation symposium.

[2]  C. Hock,et al.  Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. , 2000, Archives of neurology.

[3]  C. Haass,et al.  Neurodegenerative diseases: Parkinson's pathology in a fly , 2000, Nature.

[4]  J. Kordower,et al.  Reduction in TrkA‐Immunoreactive Neurons Is Not Associated with an Overexpression of Galaninergic Fibers Within the Nucleus Basalis in Down's Syndrome , 2000, Journal of neurochemistry.

[5]  D. Swaab,et al.  P75 Neurotrophin Receptor in the Nucleus Basalis of Meynert in Relation to Age, Sex, and Alzheimer's Disease , 2000, Experimental Neurology.

[6]  J. Thomas-Crusells,et al.  GDNF triggers a novel Ret‐independent Src kinase family‐coupled signaling via a GPI‐linked GDNF receptor α1 , 1999, FEBS letters.

[7]  B. Winblad,et al.  Decreased Plasma Insulin-Like Growth Factor-I Level in Familial Alzheimer’s Disease Patients Carrying the Swedish APP 670/671 Mutation , 1999, Dementia and Geriatric Cognitive Disorders.

[8]  G. Wilcock,et al.  Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease. , 1999, Biochemical and biophysical research communications.

[9]  J. Lowenthal,et al.  The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons , 1999, Nature Neuroscience.

[10]  L. Frölich,et al.  A Disturbance in the Neuronal Insulin Receptor Signal Transduction in Sporadic Alzheimer's Disease , 1999, Annals of the New York Academy of Sciences.

[11]  G. Giménez-Gallego,et al.  Common Binding Sites for β-Amyloid Fibrils and Fibroblast Growth Factor-2 in Heparan Sulfate from Human Cerebral Cortex* , 1999, The Journal of Biological Chemistry.

[12]  C. Hauser,et al.  TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction* , 1999, The Journal of Biological Chemistry.

[13]  J. Rothstein,et al.  Preclinical Testing of Neuroprotective Neurotrophic Factors in a Model of Chronic Motor Neuron Degeneration , 1999, Neurobiology of Disease.

[14]  M. Tabaton,et al.  Tyrosine kinase A-nerve growth factor receptor is antigenically present in dystrophic neurites from a variety of conditions but not in Alzheimer's disease , 1999, Neuroscience Letters.

[15]  F. Gage,et al.  Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[16]  D. Holtzman,et al.  Differential Effects of cAMP in Neurons and Astrocytes , 1999, The Journal of Biological Chemistry.

[17]  Timothy Sendera,et al.  Clinicopathological findings following intraventricular glial‐derived neurotrophic factor treatment in a patient with Parkinson's disease , 1999, Annals of neurology.

[18]  J. Herbert,et al.  Nerve growth factor (NGF) exerts its pro‐apoptotic effect via the P75NTR receptor in a cell cycle‐dependent manner , 1999, FEBS letters.

[19]  Z. Xia,et al.  Neuroprotection by Brain-derived Neurotrophic Factor Is Mediated by Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase* , 1999, The Journal of Biological Chemistry.

[20]  B. Fattori,et al.  Mucus of the human olfactory epithelium contains the insulin-like growth factor-I system which is altered in some neurodegenerative diseases , 1999, Brain Research.

[21]  H. Ichinose,et al.  Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease , 1999, Neuroscience Letters.

[22]  B. Ulfhake,et al.  Upregulation of GFRα‐1 and c‐ret in primary sensory neurons and spinal motoneurons of aged rats , 1999, Journal of neuroscience research.

[23]  S. Kiryu-Seo,et al.  Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats. , 1999, Brain research. Molecular brain research.

[24]  Y. Christen,et al.  Identification of β-Amyloid-Responsive Genes by RNA Differential Display: Early Induction of a DNA Damage-Inducible Gene, gadd45 , 1999, Experimental Neurology.

[25]  E. Tolosa,et al.  BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. , 1999, Journal of neuropathology and experimental neurology.

[26]  S. Wiese,et al.  Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation , 1999, The Journal of Neuroscience.

[27]  H. Hatanaka,et al.  Synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on cultured basal forebrain cholinergic neurons from postnatal 2-week-old rats. , 1999, Brain research. Developmental brain research.

[28]  D. Middlemas,et al.  Brain-derived Neurotrophic Factor Promotes Survival and Chemoprotection of Human Neuroblastoma Cells* , 1999, The Journal of Biological Chemistry.

[29]  C. Y. Wang,et al.  Differential signaling of glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons , 1999, Neuroscience.

[30]  R. Wank,et al.  Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors. , 1999, Journal of immunology.

[31]  L. Klesse,et al.  Trks: Signal transduction and intracellular pathways , 1999, Microscopy research and technique.

[32]  A. Björklund,et al.  Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle , 1999, The European journal of neuroscience.

[33]  R. Kuncl,et al.  Neuroprotective Utility and Neurotrophic Action of Neurturin in Postnatal Motor Neurons: Comparison with GDNF and Persephin , 1999, Molecular and Cellular Neuroscience.

[34]  W. Bradley A controlled trial of recombinant methionyl human BDNF in ALS , 1999, Neurology.

[35]  S. Apfel Neurotrophic Factors in Peripheral Neuropathies: Therapeutic Implications , 1999, Brain pathology.

[36]  M. Sofroniew,et al.  Leukaemia inhibitory factor prevents loss of p75-nerve growth factor receptor immunoreactivity in medial septal neurons following fimbria–fornix lesions , 1999, Neuroscience.

[37]  P. Barker,et al.  Extended Ceramide Exposure Activates the trkA Receptor by Increasing Receptor Homodimer Formation , 1999, Journal of neurochemistry.

[38]  O. Lindvall,et al.  GDNF family ligands and receptors are differentially regulated after brain insults in the rat , 1999, The European journal of neuroscience.

[39]  Miles W. Miller,et al.  Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[40]  N. Asai,et al.  Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase , 1999, Oncogene.

[41]  D. Higgins,et al.  Leukemia Inhibitory Factor and Ciliary Neurotrophic Factor Cause Dendritic Retraction in Cultured Rat Sympathetic Neurons , 1999, The Journal of Neuroscience.

[42]  M. Barone,et al.  Ret-mediated mitogenesis requires Src kinase activity. , 1999, Cancer research.

[43]  E. Masliah,et al.  Evidence for neuroprotective effects of acidic fibroblast growth factor in Alzheimer disease. , 1999, Journal of neuropathology and experimental neurology.

[44]  Hans Lassmann,et al.  Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation? , 1999, The Journal of experimental medicine.

[45]  M. Quartu,et al.  Neurotrophin-like immunoreactivity in the human hippocampal formation , 1999, Brain Research Bulletin.

[46]  E. Mufson,et al.  Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases , 1999, Progress in Neurobiology.

[47]  E. Hirsch,et al.  Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. , 1999, Neuroreport.

[48]  R. Lindsay,et al.  Characterization of receptors for ciliary neurotrophic factor on rat hippocampal astrocytes , 1999, Brain Research.

[49]  Y. Barde,et al.  Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR , 1999, The EMBO journal.

[50]  Y. Agid,et al.  An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease , 1999, Neuroscience.

[51]  W. Lee,et al.  Differential regulation of glial cell line–derived neurotrophic factor (GDNF) expression in human neuroblastoma and glioblastoma cell lines , 1999, Journal of neuroscience research.

[52]  J. Zimmer,et al.  GDNF Increases the Density of Cells Containing Calbindin but Not of Cells Containing Calretinin in Cultured Rat and Human Fetal Nigral Tissue , 1999, Cell transplantation.

[53]  G. Terenghi,et al.  Peripheral nerve regeneration and neurotrophic factors , 1999, Journal of anatomy.

[54]  E. Arenas,et al.  Intrastriatal grafting of a GDNF‐producing cell line protects striatonigral neurons from quinolinic acid excitotoxicity in vivo , 1999, The European journal of neuroscience.

[55]  C. Achim,et al.  Neuron-Enriched Second Trimester Human Cultures: Growth Factor Response and in Vivo Graft Survival , 1999, Cell transplantation.

[56]  E. Castrén,et al.  The messenger RNAs for both glial cell line-derived neurotrophic factor receptors, c- ret and GDNFRα, are induced in the rat brain in response to kainate-induced excitation , 1998, Neuroscience.

[57]  J. de Vellis,et al.  NT‐3‐mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo , 1998, Journal of neuroscience research.

[58]  C. Pozniak,et al.  P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors , 1998, The Journal of cell biology.

[59]  K. Arima,et al.  Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques , 1998, Brain Research.

[60]  J. Milbrandt,et al.  Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex , 1998, Neuron.

[61]  Steffen Roßner,et al.  The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling , 1998, Progress in Neurobiology.

[62]  J. Vilar,et al.  Regulation of c-ret expression by retinoic acid in rat metanephros: implication in nephron mass control. , 1998, American journal of physiology. Renal physiology.

[63]  S. Wiegand,et al.  Expression of BDNF and trkB as a function of age and cognitive performance , 1998, Brain Research.

[64]  M. Figiel,et al.  CNS glia are targets for GDNF and neurturin , 1998, Histochemistry and Cell Biology.

[65]  I. Ferrer,et al.  TrkA immunoreactivity in reactive astrocytes in human neurodegenerative diseases and colchicine-treated rats , 1998, Acta Neuropathologica.

[66]  Guoji Wang,et al.  Expression of brain‐derived neurotrophic factor protein in activated microglia of human immunodeficiency virus type 1 encephalitis , 1998, Neuropathology and applied neurobiology.

[67]  W. Hamel,et al.  Trk A, B, and C are commonly expressed in human astrocytes and astrocytic gliomas but not by human oligodendrocytes and oligodendroglioma , 1998, Acta Neuropathologica.

[68]  C. Altar,et al.  Neurotrophin trafficking by anterograde transport , 1998, Trends in Neurosciences.

[69]  C. Ibáñez Emerging themes in structural biology of neurotrophic factors , 1998, Trends in Neurosciences.

[70]  D. Walker,et al.  Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease , 1998, Brain Research.

[71]  A. Porter,et al.  Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis , 1998, Oncogene.

[72]  P. Mestres,et al.  The Survival-Promoting Effect of Glial Cell Line-Derived Neurotrophic Factor on Axotomized Corticospinal Neurons In Vivo Is Mediated by an Endogenous Brain-Derived Neurotrophic Factor Mechanism , 1998, The Journal of Neuroscience.

[73]  A. Davies,et al.  GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin , 1998, Current Biology.

[74]  M. Borrello,et al.  Grb2 binding to the different isoforms of Ret tyrosine kinase , 1998, Oncogene.

[75]  W. Litchy,et al.  Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy , 1998, Neurology.

[76]  S. Furukawa,et al.  Medial nigral dopamine neurons have rich neurotrophin support in humans. , 1998 .

[77]  I. Black,et al.  Novel structure of the human GDNF gene , 1998, Brain Research.

[78]  B. Winblad,et al.  Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients with Alzheimer’s Disease , 1998, Dementia and Geriatric Cognitive Disorders.

[79]  J. Milbrandt,et al.  Expression of neurturin, GDNF, and their receptors in the adult mouse CNS , 1998, The Journal of comparative neurology.

[80]  S. Goldman,et al.  Adult neurogenesis: from canaries to the clinic. , 1998, Journal of neurobiology.

[81]  S. Stinchi,et al.  Expression of mRNA encoding neurotrophins and neurotrophin receptors in human granulocytes and bone marrow cells–enhanced neurotrophin‐4 expression induced by LTB4 , 1998, Journal of leukocyte biology.

[82]  J. Rinne,et al.  Mutation Analysis of the Glial Cell Line-Derived Neurotrophic Factor Gene in Parkinson's Disease , 1998, Experimental Neurology.

[83]  E. Stachowiak,et al.  Transcriptional regulation of fibroblast growth factor-2 expression in human astrocytes: implications for cell plasticity. , 1998, Molecular biology of the cell.

[84]  J. Cummings,et al.  Alzheimer's disease , 1998, Neurology.

[85]  J. Milbrandt,et al.  Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons , 1998, The Journal of Neuroscience.

[86]  F. Gage,et al.  Cholinergic strategies for Alzheimer’s disease , 1998, Journal of Molecular Medicine.

[87]  G. M. Fox,et al.  Expression of GDNF Family Receptor Components during Development: Implications in the Mechanisms of Interaction , 1998, The Journal of Neuroscience.

[88]  Y. Agid,et al.  Tyrosine kinase B messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study , 1998, Neuroscience.

[89]  G. Schellenberg,et al.  Presenilin‐1 mutation alters NGF‐induced neurite outgrowth, calcium homeostasis, and transcription factor (AP‐1) activation in PC12 cells , 1998, Journal of neuroscience research.

[90]  R. Gibbs Impairment of Basal Forebrain Cholinergic Neurons Associated with Aging and Long-Term Loss of Ovarian Function , 1998, Experimental Neurology.

[91]  M. Dragunow,et al.  The role of neuronal growth factors in neurodegenerative disorders of the human brain , 1998, Brain Research Reviews.

[92]  T. Beach,et al.  Immunohistochemical analyses of fibroblast growth factor receptor-1 in the human substantia nigra. Comparison between normal and Parkinson's disease cases , 1998, Brain Research.

[93]  A. Buj-Bello,et al.  GFRα-4, a New GDNF Family Receptor , 1998, Molecular and Cellular Neuroscience.

[94]  N. Seki,et al.  Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFRα-1, and GFRα-2 , 1998 .

[95]  M. Santoro,et al.  Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKs): evidence for a divergence of the ERKs and JNKs pathways induced by Ret , 1998, Oncogene.

[96]  T. Beach,et al.  Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease , 1998, Brain Research.

[97]  S. Furukawa,et al.  Neutrophin switching in spinal motoneurons of amyotrophic lateral sclerosis , 1998, Neuroreport.

[98]  M. Chao,et al.  Neurotrophin receptors: mediators of life and death 1 Published on the World Wide Web on 21 October 1997. 1 , 1998, Brain Research Reviews.

[99]  N. Pavón,et al.  [Nerve growth factor and neurological diseases]. , 1998, Revista de neurologia.

[100]  N. Ip The Neurotrophins and Neuropoietic Cytokines: Two Families of Growth Factors Acting on Neural and Hematopoietic Cells , 1998, Annals of the New York Academy of Sciences.

[101]  N. Belluardo,et al.  Multiple GPI-Anchored Receptors Control GDNF-Dependent and Independent Activation of the c-Ret Receptor Tyrosine Kinase , 1998, Molecular and Cellular Neuroscience.

[102]  H. Okano,et al.  Fibroblast growth factor‐2/brain‐derived neurotrophic factor—associated maturation of new neurons generated from adult human subependymal cells , 1998, Annals of neurology.

[103]  W. Saltzman,et al.  Nerve growth factor delivery systems. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[104]  J. P. Schwartz,et al.  Involvement of cytokines in normal CNS development and neurological diseases: Recent progress and perspectives , 1998, Journal of neuroscience research.

[105]  Susan S. Taylor,et al.  Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2 , 1998, Molecular and Cellular Biology.

[106]  I. Ferrer,et al.  BDNF Up‐Regulates TrkB Protein and Prevents the Death of CA1 Neurons Following Transient Forebrain Ischemia , 1998, Brain pathology.

[107]  S. Levison,et al.  Ciliary Neurotrophic Factor Stimulates Astroglial Hypertrophyin Vivoandin Vitro , 1998, Experimental Neurology.

[108]  K. Kiuchi,et al.  Molecular Cloning and Expression Analysis of GFRα-3, a Novel cDNA Related to GDNFRα and NTNRα , 1998 .

[109]  I. Ferrer,et al.  Trk neurotrophin receptor family immunoreactivity in rat and human pituitary tissues , 1998, Neuroscience Letters.

[110]  G. Glazner,et al.  Localization of glial cell line‐derived neurotrophic factor receptor alpha and c‐ret mRNA in rat central nervous system , 1998, The Journal of comparative neurology.

[111]  A. Davies,et al.  Cytokines promote the survival of mouse cranial sensory neurones at different developmental stages , 1998, The European journal of neuroscience.

[112]  P. Bonaventure,et al.  Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3). , 1998, European journal of biochemistry.

[113]  Klaus Heese,et al.  Inflammatory Signals Induce Neurotrophin Expression in Human Microglial Cells , 1998, Journal of neurochemistry.

[114]  R. Vejsada,et al.  Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin , 1998, Neuron.

[115]  C. Hock,et al.  Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease , 1998, Neuroscience Letters.

[116]  S. Nanko,et al.  Possible association of missense mutation (Gly63Glu) of the neurotrophin-3 gene with Alzheimer's disease in Japanese , 1998, Neuroscience Letters.

[117]  E. Martí,et al.  Distribution of fibroblast growth factor receptor-1 (FGFR-1) and FGFR-3 in the hippocampus of patients with Alzheimer's disease , 1998, Neuroscience Letters.

[118]  T. Carlstedt,et al.  GDNF and its receptor component Ret in injured human nerves and dorsal root ganglia , 1998, Neuroreport.

[119]  K. Fuxe,et al.  Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel- and diencephalon of the rat , 1998, Neuroscience.

[120]  B. Volpe,et al.  Brain-derived neurotrophic factor prevents the loss of nigral neurons induced by excitotoxic striatal-pallidal lesions , 1998, Neuroscience.

[121]  J. Rubin,et al.  Hepatocyte growth factor (HGF/SF) in Alzheimer's disease , 1998, Brain Research.

[122]  G. Sobue [Neurotrophic factors and their receptor expressions in human neuropathies]. , 1997, Rinsho shinkeigaku = Clinical neurology.

[123]  H. Althaus,et al.  Nerve growth factor signal transduction in mature pig oligodendrocytes , 1997, Journal of neuroscience research.

[124]  S. Akira,et al.  IL-6-regulated transcription factors. , 1997, The international journal of biochemistry & cell biology.

[125]  M. Quartu,et al.  Neurotrophin‐like immunoreactivity in the human trigeminal ganglion , 1997, Neuroreport.

[126]  A. Ho,et al.  Regulation of Astroglial-Derived Dopaminergic Neurotrophic Factors by Interleukin-1β in the Striatum of Young and Middle-Aged Mice , 1997, Experimental Neurology.

[127]  I. Pollack,et al.  Basic fibroblast growth factor expression as a predictor of prognosis in pediatric high-grade gliomas. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

[128]  P. Gluckman,et al.  Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus. , 1997, Brain research. Molecular brain research.

[129]  A. Toledano [Growth and aging factors in physiological senility and Alzheimer's disease]. , 1997, Revista de neurologia.

[130]  E. Hirsch,et al.  Nuclear translocation of NF‐κB in cholinergic neurons of patients with Alzheimer's disease , 1997, Neuroreport.

[131]  M. Herrero,et al.  Regulation of metallothionein-III (GIF) mRNA in the brain of patients with Alzheimer disease is not impaired. , 1997, Molecular and chemical neuropathology.

[132]  D. Hilt,et al.  ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. , 1997, Neuroscience.

[133]  N. Asai,et al.  Characterization of Ret-Shc-Grb2 complex induced by GDNF, MEN 2A, and MEN 2B mutations. , 1997, Biochemical and biophysical research communications.

[134]  A. Riccio,et al.  An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons. , 1997, Science.

[135]  S. Doré,et al.  Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases. , 1997, Trends in neurosciences.

[136]  P. Bartlett,et al.  Cytokines which signal through the LIF receptor and their actions in the nervous system , 1997, Progress in Neurobiology.

[137]  T. Duong,et al.  p75 Neurotrophin receptor immunoreactivity in the aged human hypothalamus , 1997, Neuroscience Letters.

[138]  C. Geula,et al.  Age‐related loss of calbindin from human basal forebrain cholinergic neurons , 1997, Neuroreport.

[139]  E. Clarkson,et al.  GDNF improves survival and reduces apoptosis in human embryonic dopaminergic neurons in vitro , 1997, Cell and Tissue Research.

[140]  N. Lavine,et al.  Reduction in p140-TrkA Receptor Protein within the Nucleus Basalis and Cortex in Alzheimer's Disease , 1997, Experimental Neurology.

[141]  Y. Barde,et al.  Signalling through the neurotrophin receptor p75NTR , 1997, Current Opinion in Neurobiology.

[142]  J. Cedarbaum,et al.  Endogenous NGF and CNTF levels in human peripheral nerve injury , 1997, Neuroreport.

[143]  N. Belluardo,et al.  Complementary and Overlapping Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF), c-ret Proto-Oncogene, and GDNF Receptor-α Indicates Multiple Mechanisms of Trophic Actions in the Adult Rat CNS , 1997, The Journal of Neuroscience.

[144]  E. Hirsch,et al.  Decreased TrkA Gene Expression in Cholinergic Neurons of the Striatum and Basal Forebrain of Patients with Alzheimer's Disease , 1997, Experimental Neurology.

[145]  P. McNeeley,et al.  EVALUATION OF HUMAN ASTROCYTOMA AND GLIOBLASTOMA CELL LINES FOR NERVE GROWTH FACTOR RELEASE , 1997, Neurochemistry International.

[146]  F. Hamada,et al.  NEUROTROPHINS AND THEIR RECEPTORS IN NERVE INJURY AND REPAIR , 1997, Neurochemistry International.

[147]  D. F. Howard,et al.  Gene Therapeutic Strategies for Neuroprotection: Implications for Parkinson's Disease , 1997, Experimental Neurology.

[148]  S. Numan,et al.  Increased Expression of trkB mRNA in Rat Caudate‐Putamen Following 6–OHDA Lesions of the Nigrostriatal Pathway , 1997, The European journal of neuroscience.

[149]  T. Kameyama,et al.  Orally active NGF synthesis stimulators: potential therapeutic agents in alzheimer's disease , 1997, Behavioural Brain Research.

[150]  J. Kordower,et al.  Ciliary neurotrophic factor receptor α‐immunoreactivity in the monkey central nervous system , 1997 .

[151]  E. Hirsch,et al.  Expression of catalytic trkB gene in the striatum and the basal forebrain of patients with Alzheimer's disease: an in situ hybridization study , 1997, Neuroscience Letters.

[152]  E. Mufson,et al.  Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease , 1996, Neuroreport.

[153]  J. Lavail,et al.  Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes , 1996, The Journal of Neuroscience.

[154]  J. Milbrandt,et al.  Neurturin, a relative of glial-cell-line-derived neurotrophic factor , 1996, Nature.

[155]  S. Tsuji,et al.  Regional specificity of alterations in NGF, BDNF and NT‐3 levels in Alzheimer's disease , 1996, Neuroreport.

[156]  S. Skaper,et al.  Nerve growth factor: from neurotrophin to neurokine , 1996, Trends in Neurosciences.

[157]  R. Faull,et al.  Trk receptor alterations in Alzheimer's disease. , 1996, Brain research. Molecular brain research.

[158]  T. Munsat,et al.  Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis , 1996, Neurology.

[159]  J. Engele,et al.  Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways , 1996, Cell and Tissue Research.

[160]  S. Jiao,et al.  Pharmacological characterization of glial cell line-derived neurotrophic factor (GDNF): implications for GDNF as a therapeutic molecule for treating neurodegenerative diseases , 1996, Cell and Tissue Research.

[161]  P. Dijkhuizen,et al.  Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease , 1996, Neuroscience.

[162]  D. Holtzman,et al.  Nerve growth factor and the neurotrophic factor hypothesis , 1996, Brain and Development.

[163]  W. Mobley,et al.  Therapeutic potential of neurotrophic factors for neurological disorders , 1996, Annals of neurology.

[164]  E. Gelfand,et al.  Nerve growth factor signal transduction in human B lymphocytes is mediated by gp140trk , 1996, European journal of immunology.

[165]  H. Kiyama,et al.  Characteristic Localization of gpl30 (the Signal‐transducing Receptor Component Used in Common for IL‐6/IL‐11/CNTF/LIF/OSM) in the Rat Brain , 1996, The European journal of neuroscience.

[166]  A. Windebank,et al.  Localization and Expression of Ciliary Neurotrophic Factor (CNTF) in Postmortem Sciatic Nerve from Patients with Motor Neuron Disease and Diabetic Neuropathy , 1996, Journal of neuropathology and experimental neurology.

[167]  A. Buj-Bello,et al.  Characterization of a multicomponent receptor for GDNF , 1996, Nature.

[168]  E. Arenas,et al.  Functional receptor for GDNF encoded by the c-ret proto-oncogene , 1996, Nature.

[169]  B. Ponder,et al.  GDNF signalling through the Ret receptor tyrosine kinase , 1996, Nature.

[170]  Myriam Schluep,et al.  Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients , 1996, Nature Medicine.

[171]  J. W. Lichtman,et al.  Are Neurotrophins Synaptotrophins? , 1996, Molecular and Cellular Neuroscience.

[172]  H. Gao,et al.  Neurotrophins and Alzheimer's disease: beyond the cholinergic neurons. , 1996, Life sciences.

[173]  F. Fumagalli,et al.  Cyclic AMP-dependent regulation of fibroblast growth factor-2 messenger RNA levels in rat cortical astrocytes: comparison with fibroblast growth factor-1 and ciliary neurotrophic factor. , 1996, Molecular pharmacology.

[174]  V. Hans,et al.  Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes , 1996, Brain Research.

[175]  B. Hoffer,et al.  Functional recovery in parkinsonian monkeys treated with GDNF , 1996, Nature.

[176]  G. Parry,et al.  A placebo‐controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis , 1996 .

[177]  E. Arenas,et al.  GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo , 1995, Neuron.

[178]  X. Breakefield,et al.  Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease , 1995, Brain Research.

[179]  C. Portera-Cailliau,et al.  Nerve growth factor prevents apoptotic cell death in injured central cholinergic neurons , 1995, The Journal of comparative neurology.

[180]  E. Mufson,et al.  Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[181]  L. Olson,et al.  Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[182]  A. Björklund,et al.  Brain-derived neurotrophic factor and neurotrophin- 4 5 modify neurotransmitter-related gene expression in the 6-hydroxydopamine-lesioned rat striatum , 1995, Neuroscience.

[183]  C. Ibáñez,et al.  Synergistic Trophic Actions on Rat Basal Forebrain Neurons Revealed by a Synthetic NGF/BDNF Chimaeric Molecule , 1995, The European journal of neuroscience.

[184]  Randolph M. Johnson,et al.  Dose-response comparison of recombinant human nerve growth factor and recombinant human basic fibroblast growth factor in the fimbria fornix model of acute cholinergic degeneration , 1995, Brain Research.

[185]  K. Unsicker,et al.  TGF‐beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. , 1995, The EMBO journal.

[186]  L. Olson,et al.  Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo , 1995, Nature.

[187]  Stanley J. Wiegand,et al.  Neurotrophic factors: from molecule to man , 1994, Trends in Neurosciences.

[188]  I. Black,et al.  Multiple Astrocyte Transcripts Encode Nigral Trophic Factors in Rat and Human , 1994, Experimental Neurology.

[189]  H. Kimura,et al.  Acidic FGF expression in the surroundings of senile plaques. , 1994, The Tohoku journal of experimental medicine.

[190]  R. Lindsay,et al.  The Neurotrophins NT-4/5 and BDNF Augment Serotonin, Dopamine, and GABAergic Systems during Behaviorally Effective Infusions to the Substantia Nigra , 1994, Experimental Neurology.

[191]  P. Riederer,et al.  Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients , 1994, Neuroscience Letters.

[192]  J. Trojanowski,et al.  Expression of GDNF mRNA in Rat and Human Nervous Tissue , 1994, Experimental Neurology.

[193]  M. Beal,et al.  Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[194]  E. Arenas,et al.  Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo , 1994, Nature.

[195]  Rhonda,et al.  Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[196]  I. Tooyama [Fibroblast growth factors (FGFs) in neurodegenerative disorders]. , 1993, Rinsho shinkeigaku = Clinical neurology.

[197]  H. Yeh,et al.  Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[198]  J. Lile,et al.  GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. , 1993, Science.

[199]  J. Langston,et al.  Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection , 1993, Neuroscience.

[200]  H. Kimura,et al.  Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease , 1993, Neurology.

[201]  F. Gage,et al.  Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain , 1991, Annals of neurology.

[202]  Steven A. Johnson,et al.  BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease , 1991, Neuron.

[203]  J. Engele,et al.  The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685] , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[204]  D. Casper,et al.  EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture , 1991, Journal of neuroscience research.

[205]  G. Yancopoulos,et al.  BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra , 1991, Nature.

[206]  D. Price,et al.  Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[207]  D. Price,et al.  Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells , 1990, Experimental Neurology.

[208]  D. Amaral,et al.  Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[209]  I. Date,et al.  MPTP-treated young mice but not aging mice show partial recovery of the nigrostriatal dopaminergic system by stereotaxic injection of acidic fibroblast growth factor (aFGF) , 1990, Brain Research.

[210]  F. Gage,et al.  Grafting genetically modified cells to the brain: Possibilities for the future , 1987, Neuroscience.

[211]  F. Gage,et al.  Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor , 1987, Nature.

[212]  F. Hefti,et al.  Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[213]  M. Shigemori,et al.  Fibroblast growth factor-9 (glia-activating factor) stimulates proliferation and production of glial fibrillary acidic protein in human gliomas either in the presence or in the absence of the endogenous growth factor expression. , 1999, Oncology reports.

[214]  K. Walton,et al.  GDNF: a novel factor with therapeutic potential for neurodegenerative disorders. , 1999, Molecular neurobiology.

[215]  E. Jauniaux,et al.  Neurotrophins in the pathogenesis and potential treatment of Parkinson's disease. , 1999, Advances in neurology.

[216]  U. Kang,et al.  Potential of gene therapy for Parkinson's disease: neurobiologic issues and new developments in gene transfer methodologies. , 1998, Movement disorders : official journal of the Movement Disorder Society.

[217]  C. Sommer,et al.  BDNF and TrkB expression in intrastriatal ventral mesencephalic grafts in a rat model of Parkinson's disease , 1998, Journal of Neural Transmission.

[218]  G. Gerhardt,et al.  Effects of glial cell line-derived neurotrophic factor on the nigrostriatal dopamine system in rodents and nonhuman primates. , 1998, Advances in pharmacology.

[219]  M. Tuszynski,et al.  Neurotrophin gene therapy in CNS models of trauma and degeneration. , 1998, Progress in brain research.

[220]  D. Swaab,et al.  Neuronal activity and genetic background in Alzheimer's disease , 1998 .

[221]  D. Lindholm Models to study the role of neurotrophic factors in neurodegeneration. , 1997, Journal of neural transmission. Supplementum.

[222]  T L Babb,et al.  Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus. , 1997, Molecular and chemical neuropathology.

[223]  L. Olson,et al.  Treatment strategies for neurodegenerative diseases based on trophic factors and cell transplantation techniques. , 1997, Journal of neural transmission. Supplementum.

[224]  J. Thome,et al.  Ciliary neurotrophic factor (CNTF) genotypes: influence on choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) activities and neurotrophin 3 (NT3) concentration in human post mortem brain tissue. , 1997, Journal fur Hirnforschung.

[225]  R. Penn,et al.  Intrathecal Ciliary Neurotrophic Factor Delivery for Treatment of Amyotrophic Lateral Sclerosis (Phase I Trial) , 1997 .

[226]  H. Phillips,et al.  Neurotrophic‐4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures , 1994 .

[227]  G. Yancopoulos,et al.  Ciliary neurotrophic factor and its receptor complex. , 1992, Progress in growth factor research.

[228]  F. Hefti,et al.  Trophic actions of IGF-I, IGF-II and insulin on cholinergic and dopaminergic brain neurons. , 1991, Advances in experimental medicine and biology.

[229]  H. Steinbusch,et al.  Basic fibroblast growth factor enhances survival and sprouting of fetal dopaminergic cells implanted in the denervated rat caudate-putamen: preliminary observations. , 1990, Progress in brain research.