fMRI of Generalized Absence Status Epilepticus in Conscious Marmoset Monkeys Reveals Corticothalamic Activation

Summary:  Purpose: A nonhuman primate model of generalized absence status epilepticus was developed for use in functional magnetic resonance imaging (fMRI) experiments to elucidate the brain mechanisms underlying this disorder.

[1]  Miriam Scadeng,et al.  Direct comparison of visual cortex activation in human and non-human primates using functional magnetic resonance imaging , 2001, Journal of Neuroscience Methods.

[2]  Dr. Heinz Stephan,et al.  The Brain of the Common Marmoset (Callithrix jacchus) , 1980, Springer Berlin Heidelberg.

[3]  R. S. Hinks,et al.  Time course EPI of human brain function during task activation , 1992, Magnetic resonance in medicine.

[4]  Reinhold Ludwig,et al.  Corticothalamic Modulation during Absence Seizures in Rats: A Functional MRI Assessment , 2003, Epilepsia.

[5]  Anders H. Andersen,et al.  Functional MRI of apomorphine activation of the basal ganglia in awake rhesus monkeys , 2000, Brain Research.

[6]  N. Logothetis,et al.  Neurophysiological investigation of the basis of the fMRI signal , 2001, Nature.

[7]  O. Snead,et al.  Thalamic mediodorsal and intralaminar nuclear lesions disrupt the generation of experimentally induced generalized absence-like seizures in rats , 1994, Epilepsy Research.

[8]  J. Leysen,et al.  Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain. , 2000, Brain research. Molecular brain research.

[9]  Pegram Gv,et al.  Antagonism of gamma-hydroxybutyric acid-induced frequency shifts in the cortical EEG of rats by dipropylacetate. , 1980, Electroencephalography and clinical neurophysiology.

[10]  T. Duong,et al.  Changes in MRI signal intensity during hypercapnic challenge under conscious and anesthetized conditions. , 2003, Magnetic resonance imaging.

[11]  A. Depaulis,et al.  Spontaneous spike and wave discharges in thalamus and cortex in a rat model of genetic petit mal-like seizures , 1987, Experimental Neurology.

[12]  Karl J. Friston,et al.  Functional magnetic resonance imaging of human absence seizures , 2003, Annals of neurology.

[13]  O. Snead,et al.  Basic mechanisms of generalized absence seizures , 1995, Annals of neurology.

[14]  Richard F. Martin,et al.  Primate brain maps : structure of the macaque brain , 2000 .

[15]  D. Fujikawa,et al.  Metabolic anatomy of generalized bicuculline seizures in the newborn marmoset monkey , 1986, Experimental Neurology.

[16]  Ravi S. Menon,et al.  Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. , 1993, Biophysical journal.

[17]  Antoine Depaulis,et al.  Mapping of spontaneous spike and wave discharges in Wistar rats with genetic generalized non-convulsive epilepsy , 1990, Brain Research.

[18]  S Warach,et al.  Monitoring the patient's EEG during echo planar MRI. , 1993, Electroencephalography and clinical neurophysiology.

[19]  K. Holland,et al.  Efficacy, pharmacology, and adverse effects of antiepileptic drugs. , 2001, Neurologic clinics.

[20]  T. Duong,et al.  Activation of neural pathways associated with sexual arousal in non‐human primates , 2004, Journal of magnetic resonance imaging : JMRI.

[21]  C. Ferris,et al.  Imaging brain activity in conscious animals using functional MRI , 1998, Journal of Neuroscience Methods.

[22]  F. H. Lopes da Silva,et al.  Cortical Focus Drives Widespread Corticothalamic Networks during Spontaneous Absence Seizures in Rats , 2002, The Journal of Neuroscience.

[23]  M. Vergnes,et al.  Calcium‐Dependent Regulation of Genetically Determined Spike and Waves by the Reticular Thalamic Nucleus of Rats , 1993, Epilepsia.

[24]  O. Snead Gamma hydroxybutyrate in the monkey , 1978, Neurology.

[25]  D. Born,et al.  Development of a Model of Status epilepticus in Pigtailed Macaque Infant Monkeys , 1999, Developmental Neuroscience.

[26]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[27]  T. Duong,et al.  Regional Cerebral Blood Flow and BOLD Responses in Conscious and Anesthetized Rats under Basal and Hypercapnic Conditions: Implications for Functional MRI Studies , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[28]  R. Turner,et al.  Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[29]  S. Ogawa,et al.  Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields , 1990, Magnetic resonance in medicine.

[30]  C. Ferris,et al.  A dual RF resonator system for high-field functional magnetic resonance imaging of small animals , 2004, Journal of Neuroscience Methods.

[31]  Anthony B Waites,et al.  fMRI “deactivation” of the posterior cingulate during generalized spike and wave , 2003, NeuroImage.

[32]  T Seidenbecher,et al.  Relations between cortical and thalamic cellular activities during absence seizures in rats , 1998, The European journal of neuroscience.

[33]  M. Curtis,et al.  The role of the thalamus in vigilance and epileptogenic mechanisms , 2000, Clinical Neurophysiology.

[34]  D. Fujikawa,et al.  Generalized seizures deplete brain energy reserves in normoxemic newborn monkeys , 1988, Brain Research.

[35]  C P Panayiotopoulos,et al.  Typical absence seizures and their treatment , 1999, Archives of disease in childhood.

[36]  O. Snead,et al.  Antagonism of gamma-hydroxybutyric acid-induced frequency shifts in the cortical EEG of rats by dipropylacetate. , 1980, Electroencephalography and Clinical Neurophysiology.

[37]  Jeffrey R Tenney,et al.  fMRI of Brain Activation in a Genetic Rat Model of Absence Seizures , 2004, Epilepsia.

[38]  N. Logothetis,et al.  Functional imaging of the monkey brain , 1999, Nature Neuroscience.

[39]  D. Fujikawa,et al.  Preferential blood flow to brainstem during generalized seizures in the newborn marmoset monkey , 1986, Brain Research.

[40]  C. W. Watson,et al.  Bilateral synchronous spike wave electrographic patterns in the cat. Interaction of bilateral cortical foci in the intact, the bilateral cortical-callosal, and adiencephalic preparation. , 1966, Archives of neurology.

[41]  K Ugurbil,et al.  Functional imaging of brain activity in conscious monkeys responding to sexually arousing cues , 2001, Neuroreport.

[42]  R. S. Grewal,et al.  Arrest reaction with concomitant spike and wave afterdischarge following thalamic stimulation in conscious juvenile monkeys with Al (OH)3 focal premotor lesions. , 1981, Indian journal of physiology and pharmacology.

[43]  Richard Grondin,et al.  Pharmacological MRI Mapping of Age-Associated Changes in Basal Ganglia Circuitry of Awake Rhesus Monkeys , 2001, NeuroImage.

[44]  J. Strupp Stimulate: A GUI based fMRI analysis software package , 1996, NeuroImage.

[45]  R A Andersen,et al.  Functional magnetic resonance imaging in macaque cortex , 1998, Neuroreport.

[46]  D. Fujikawa,et al.  Local cerebral glucose utilization during status epilepticus in newborn primates. , 1989, The American journal of physiology.

[47]  H N Mallick,et al.  Stereotaxic assembly and procedures for simultaneous electrophysiological and MRI study of conscious rat , 2003, Magnetic resonance in medicine.