KIF14 negatively regulates Rap1a–Radil signaling during breast cancer progression

The kinesin KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on microtubules.

[1]  Y. Daaka,et al.  Rap1GAP regulates renal cell carcinoma invasion. , 2012, Cancer letters.

[2]  D. Mukhopadhyay,et al.  Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer. , 2012, ACS chemical biology.

[3]  B. Gallie,et al.  Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer , 2012, International journal of cancer.

[4]  Margaret L. Gardel,et al.  Tension is required but not sufficient for focal adhesion maturation without a stress fiber template , 2012, The Journal of cell biology.

[5]  Daisuke Hoshino,et al.  Turnover of Focal Adhesions and Cancer Cell Migration , 2012, International journal of cell biology.

[6]  O. Kallioniemi,et al.  SHARPIN is an endogenous inhibitor of β1-integrin activation , 2011, Nature Cell Biology.

[7]  M. Ginsberg,et al.  Regulation of integrin activation. , 2011, Annual review of cell and developmental biology.

[8]  Johanna Ivaska,et al.  Filopodia and adhesion in cancer cell motility , 2011, Cell adhesion & migration.

[9]  J. Bos,et al.  Ezrin is required for efficient Rap1-induced cell spreading , 2011, Journal of Cell Science.

[10]  S. Varambally,et al.  The tumor suppressor gene rap1GAP is silenced by mir-101-mediated EZH2 overexpression in invasive squamous cell carcinoma , 2011, Oncogene.

[11]  M. Henry,et al.  A Critical Role of Gβγ in Tumorigenesis and Metastasis of Breast Cancer* , 2011, The Journal of Biological Chemistry.

[12]  S. Angers,et al.  Tandem affinity purification and identification of heterotrimeric g protein-associated proteins. , 2011, Methods in molecular biology.

[13]  David A. Cheresh,et al.  Integrins in cancer: biological implications and therapeutic opportunities , 2010, Nature Reviews Cancer.

[14]  Clare M Waterman,et al.  Mechanical integration of actin and adhesion dynamics in cell migration. , 2010, Annual review of cell and developmental biology.

[15]  Hongyan Chen,et al.  Kif18A is involved in human breast carcinogenesis. , 2010, Carcinogenesis.

[16]  Martin A. Schwartz,et al.  Cell adhesion: integrating cytoskeletal dynamics and cellular tension , 2010, Nature Reviews Molecular Cell Biology.

[17]  M. Gold,et al.  Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs. , 2010, Cancer research.

[18]  H. Kiyonari,et al.  Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme , 2010, Proceedings of the National Academy of Sciences.

[19]  K. Kaibuchi,et al.  Binding of APC and dishevelled mediates Wnt5a‐regulated focal adhesion dynamics in migrating cells , 2010, The EMBO journal.

[20]  P. Abel,et al.  Gβγ Signaling Promotes Breast Cancer Cell Migration and Invasion , 2010, Journal of Pharmacology and Experimental Therapeutics.

[21]  S. Angers,et al.  G Protein βγ Subunits Regulate Cell Adhesion through Rap1a and Its Effector Radil , 2010, The Journal of Biological Chemistry.

[22]  Harel Weinstein,et al.  Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD , 2009, Proceedings of the National Academy of Sciences.

[23]  K. Verhey,et al.  Traffic control: regulation of kinesin motors , 2009, Nature Reviews Molecular Cell Biology.

[24]  N. Hirokawa,et al.  Kinesin superfamily motor proteins and intracellular transport , 2009, Nature Reviews Molecular Cell Biology.

[25]  M. Houslay Disrupting specific PDZ domain‐mediated interactions for therapeutic benefit , 2009, British journal of pharmacology.

[26]  J. de Gunzburg,et al.  Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis , 2009, Journal of Cell Science.

[27]  G. Mills,et al.  β-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells , 2009, Molecular Cancer Research.

[28]  P. Casey,et al.  Activation of Rap1 promotes prostate cancer metastasis. , 2009, Cancer research.

[29]  R. Hannoush,et al.  Inhibition of Wnt signaling by Dishevelled PDZ peptides. , 2009, Nature chemical biology.

[30]  C. Lim,et al.  RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences* , 2009, Journal of Biological Chemistry.

[31]  D. Huszar,et al.  Kinesin motor proteins as targets for cancer therapy , 2009, Cancer and Metastasis Reviews.

[32]  L. Cornelius,et al.  Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. , 2009, Cancer research.

[33]  B. Geiger,et al.  Environmental sensing through focal adhesions , 2009, Nature Reviews Molecular Cell Biology.

[34]  Gaudenz Danuser,et al.  Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed , 2008, The Journal of cell biology.

[35]  J. Bos,et al.  PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. , 2008, European journal of cell biology.

[36]  Chris Sander,et al.  A Specificity Map for the PDZ Domain Family , 2008, PLoS biology.

[37]  J. Bos,et al.  cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics. , 2008, Cellular signalling.

[38]  M. Duncan,et al.  Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasion. , 2008, Cancer research.

[39]  K. Moelling,et al.  c-Src-Mediated Epithelial Cell Migration and Invasion Regulated by PDZ Binding Site , 2007, Molecular and Cellular Biology.

[40]  R. Gautier,et al.  Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein‐1 , 2007, The FEBS journal.

[41]  M. Ginsberg,et al.  KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions , 2007, The Journal of cell biology.

[42]  Yan Leng,et al.  Abelson Interactor Protein-1 Positively Regulates Breast Cancer Cell Proliferation, Migration, and Invasion , 2007, Molecular Cancer Research.

[43]  A. Look,et al.  A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. , 2007, Genes & development.

[44]  M. Feldman,et al.  Downregulation of Rap1GAP Contributes to Ras Transformation , 2007, Molecular and Cellular Biology.

[45]  K. Moelling,et al.  Regulation of c‐Src by binding to the PDZ domain of AF‐6 , 2007, The EMBO journal.

[46]  T. Corson,et al.  KIF14 Messenger RNA Expression Is Independently Prognostic for Outcome in Lung Cancer , 2007, Clinical Cancer Research.

[47]  E. Bruyneel,et al.  The tandem PDZ domains of syntenin promote cell invasion. , 2007, Experimental cell research.

[48]  M. Bissell,et al.  Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. , 2007, Cancer research.

[49]  Richard A. Firtel,et al.  Rap1 controls cell adhesion and cell motility through the regulation of myosin II , 2007, The Journal of cell biology.

[50]  John G. Collard,et al.  The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization , 2007, The Journal of cell biology.

[51]  G. Parmigiani,et al.  The Consensus Coding Sequences of Human Breast and Colorectal Cancers , 2006, Science.

[52]  N. Watanabe,et al.  Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3 , 2006, Current Biology.

[53]  T. Corson,et al.  KIF14 mRNA expression is a predictor of grade and outcome in breast cancer , 2006, International journal of cancer.

[54]  Peter S. Linsley,et al.  RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure , 2006, Molecular and Cellular Biology.

[55]  Erich A. Nigg,et al.  KIF14 and citron kinase act together to promote efficient cytokinesis , 2006, The Journal of cell biology.

[56]  N. Watanabe,et al.  Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. , 2006, Current biology : CB.

[57]  M. Bissell,et al.  Rap 1 Integrates Tissue Polarity , Lumen Formation , and Tumorigenic Potential in Human Breast Epithelial Cells , 2006 .

[58]  E. Nigg,et al.  KIF 14 and citron kinase act together to promote effi cient cytokinesis , 2006 .

[59]  K. Katagiri,et al.  Regulation of immune cell adhesion and migration by regulator of adhesion and cell polarization enriched in lymphoid tissues , 2005, Immunology.

[60]  Timothy W Corson,et al.  KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers , 2005, Oncogene.

[61]  Neil O. Carragher,et al.  The role of focal-adhesion kinase in cancer — a new therapeutic opportunity , 2005, Nature Reviews Cancer.

[62]  M. Smyth,et al.  A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. , 2005, Immunity.

[63]  J. Bos Linking Rap to cell adhesion. , 2005, Current opinion in cell biology.

[64]  N. Mochizuki,et al.  Local Activation of Rap1 Contributes to Directional Vascular Endothelial Cell Migration Accompanied by Extension of Microtubules on Which RAPL, a Rap1-associating Molecule, Localizes* , 2005, Journal of Biological Chemistry.

[65]  Jonathan A. Cooper,et al.  Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors , 2004, The Journal of cell biology.

[66]  G. Freeman,et al.  RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. , 2004, Developmental cell.

[67]  M. Sheng,et al.  PDZ domain proteins of synapses , 2004, Nature Reviews Neuroscience.

[68]  G. Crooks,et al.  WebLogo: a sequence logo generator. , 2004, Genome research.

[69]  K. Katagiri,et al.  Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL. , 2004, Immunology letters.

[70]  T. Bivona,et al.  Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion , 2004, The Journal of cell biology.

[71]  B. Felding-Habermann,et al.  Integrin adhesion receptors in tumor metastasis , 2004, Clinical & Experimental Metastasis.

[72]  K. Katagiri,et al.  RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1 , 2003, Nature Immunology.

[73]  H. Richardson,et al.  Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[74]  S. Dedhar,et al.  αv integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells , 2003, Oncogene.

[75]  J. Bos,et al.  The role of Rap1 in integrin-mediated cell adhesion. , 2001, Biochemical Society transactions.

[76]  S. Dedhar,et al.  alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells. , 2003, Oncogene.

[77]  Alexey I Nesvizhskii,et al.  Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. , 2002, Analytical chemistry.

[78]  Irina Kaverina,et al.  Regulation of substrate adhesion dynamics during cell motility. , 2002, The international journal of biochemistry & cell biology.

[79]  N. Hogg,et al.  Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling , 2002, Nature Immunology.

[80]  J. Small,et al.  Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1 , 2002, The Journal of cell biology.

[81]  W. Lim,et al.  Mechanism and role of PDZ domains in signaling complex assembly. , 2001, Journal of cell science.

[82]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[83]  J W Smith,et al.  Integrin activation controls metastasis in human breast cancer. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[84]  M. Sheng,et al.  PDZ domains and the organization of supramolecular complexes. , 2001, Annual review of neuroscience.

[85]  L. Van Aelst,et al.  The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[86]  S. Kuwada,et al.  Integrin α5/β1 Mediates Fibronectin-dependent Epithelial Cell Proliferation through Epidermal Growth Factor Receptor Activation , 2000 .

[87]  E. Rosen,et al.  Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes , 2000, Journal of Molecular Medicine.

[88]  S. Kuwada,et al.  Integrin alpha5/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation. , 2000, Molecular biology of the cell.

[89]  James M. Anderson,et al.  PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. , 1999, The Journal of clinical investigation.

[90]  A. Wittinghofer,et al.  Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP , 1998, Nature.

[91]  S. Shenolikar,et al.  The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange , 1998, Nature.

[92]  J. Vasiliev,et al.  KINESIN‐ASSOCIATED TRANSPORT IS INVOLVED IN THE REGULATION OF CELL ADHESION , 1997, Cell biology international.

[93]  K. Kaibuchi,et al.  Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase , 1997, Science.

[94]  P. Watson,et al.  The NCIC-Manitoba Breast Tumor Bank: a resource for applied cancer research. , 1996, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[95]  K. Burridge,et al.  Rho-stimulated contractility drives the formation of stress fibers and focal adhesions , 1996, The Journal of cell biology.

[96]  F. Wurm,et al.  Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. , 1996, Nucleic acids research.

[97]  J. Yates,et al.  An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database , 1994, Journal of the American Society for Mass Spectrometry.

[98]  D. Carey,et al.  Localization of a heterotrimeric G protein gamma subunit to focal adhesions and associated stress fibers , 1994, The Journal of cell biology.

[99]  G. Rubin,et al.  Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase , 1991, Cell.

[100]  F. McCormick,et al.  Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21 rap1 , 1991, Cell.

[101]  T. D. Schneider,et al.  Sequence logos: a new way to display consensus sequences. , 1990, Nucleic acids research.

[102]  D A Scudiero,et al.  Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. , 1988, Cancer research.

[103]  L. Santambrogio,et al.  The lipid kinase PI4KIIIβ preserves lysosomal identity , 2012, The EMBO journal.

[104]  M. Czaja,et al.  Regulation of lipid stores and metabolism by lipophagy , 2012, Cell Death and Differentiation.

[105]  T. Springer,et al.  α(V)β(3) integrin crystal structures and their functional implications. , 2012, Biochemistry.

[106]  Y. Li,et al.  Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation , 2012, Nature Cell Biology.

[107]  Y. Daaka,et al.  Rap1GAP regulates renal cell carcinoma invasion. , 2012, Cancer letters.

[108]  Robert V Farese,et al.  Lipid droplets and cellular lipid metabolism. , 2012, Annual review of biochemistry.

[109]  D. Mukhopadhyay,et al.  Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer. , 2012, ACS chemical biology.

[110]  B. Gallie,et al.  Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer , 2012, International journal of cancer.

[111]  Y. Sugita,et al.  Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor , 2012, The Journal of cell biology.

[112]  Marcus J. Taylor,et al.  A Feedback Loop between Dynamin and Actin Recruitment during Clathrin-Mediated Endocytosis , 2012, PLoS biology.

[113]  A. Cuervo,et al.  Lipophagy: Connecting Autophagy and Lipid Metabolism , 2012, International journal of cell biology.

[114]  T. Springer,et al.  GARP regulates the bioavailability and activation of TGFβ , 2012, Molecular biology of the cell.

[115]  Margaret L. Gardel,et al.  Tension is required but not sufficient for focal adhesion maturation without a stress fiber template , 2012, The Journal of cell biology.

[116]  Michael Loran Dustin,et al.  Integrin inside-out signaling and the immunological synapse. , 2012, Current opinion in cell biology.

[117]  Daisuke Hoshino,et al.  Turnover of Focal Adhesions and Cancer Cell Migration , 2012, International journal of cell biology.

[118]  T. Walz,et al.  Structural specializations of α4β7, an integrin that mediates rolling adhesion , 2012, The Journal of cell biology.

[119]  P. Beaune,et al.  The Dynamin Chemical Inhibitor Dynasore Impairs Cholesterol Trafficking and Sterol-Sensitive Genes Transcription in Human HeLa Cells and Macrophages , 2011, PloS one.

[120]  T. Springer,et al.  Regulation of integrin affinity on cell surfaces , 2011, The EMBO journal.

[121]  O. Kallioniemi,et al.  SHARPIN is an endogenous inhibitor of β1-integrin activation , 2011, Nature Cell Biology.

[122]  M. Ginsberg,et al.  Regulation of integrin activation. , 2011, Annual review of cell and developmental biology.

[123]  Johanna Ivaska,et al.  Filopodia and adhesion in cancer cell motility , 2011, Cell adhesion & migration.

[124]  T. Walz,et al.  Intact αIIbβ3 Integrin Is Extended after Activation as Measured by Solution X-ray Scattering and Electron Microscopy* , 2011, The Journal of Biological Chemistry.

[125]  T. Walz,et al.  Latent TGF-β structure and activation , 2011, Nature.

[126]  M. Czaja,et al.  Regulation of lipid droplets by autophagy , 2011, Trends in Endocrinology & Metabolism.

[127]  J. Bos,et al.  Ezrin is required for efficient Rap1-induced cell spreading , 2011, Journal of Cell Science.

[128]  S. Varambally,et al.  The tumor suppressor gene rap1GAP is silenced by mir-101-mediated EZH2 overexpression in invasive squamous cell carcinoma , 2011, Oncogene.

[129]  M. Henry,et al.  A Critical Role of Gβγ in Tumorigenesis and Metastasis of Breast Cancer* , 2011, The Journal of Biological Chemistry.

[130]  S. Angers,et al.  Tandem affinity purification and identification of heterotrimeric g protein-associated proteins. , 2011, Methods in molecular biology.

[131]  T. Springer,et al.  Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. , 2010, Blood.

[132]  David A. Cheresh,et al.  Integrins in cancer: biological implications and therapeutic opportunities , 2010, Nature Reviews Cancer.

[133]  Clare M Waterman,et al.  Mechanical integration of actin and adhesion dynamics in cell migration. , 2010, Annual review of cell and developmental biology.

[134]  Yukiko Sato,et al.  Structural Requirements for Activation in αIIbβ3 Integrin* , 2010, The Journal of Biological Chemistry.

[135]  M. McNiven,et al.  A Dyn2–CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding , 2010, The EMBO journal.

[136]  Hongyan Chen,et al.  Kif18A is involved in human breast carcinogenesis. , 2010, Carcinogenesis.

[137]  Martin A. Schwartz,et al.  Cell adhesion: integrating cytoskeletal dynamics and cellular tension , 2010, Nature Reviews Molecular Cell Biology.

[138]  T. Walz,et al.  Requirement of open headpiece conformation for activation of leukocyte integrin αXβ2 , 2010, Proceedings of the National Academy of Sciences.

[139]  D. Baker,et al.  Modulation of Integrin Activation by an Entropic Spring in the β-Knee* , 2010, Journal of Biological Chemistry.

[140]  P. Evans,et al.  A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex , 2010, Cell.

[141]  D. Hailey,et al.  Autophagy termination and lysosome reformation regulated by mTOR , 2010, Nature.

[142]  S. Schmid,et al.  Multivalent Display and Receptor‐Mediated Endocytosis of Transferrin on Virus‐Like Particles , 2010, Chembiochem : a European journal of chemical biology.

[143]  M. Gold,et al.  Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs. , 2010, Cancer research.

[144]  H. Kiyonari,et al.  Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme , 2010, Proceedings of the National Academy of Sciences.

[145]  K. Kaibuchi,et al.  Binding of APC and dishevelled mediates Wnt5a‐regulated focal adhesion dynamics in migrating cells , 2010, The EMBO journal.

[146]  M. Scott,et al.  The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. , 2010, Genes & development.

[147]  P. Bassereau,et al.  Membrane curvature controls dynamin polymerization , 2010, Proceedings of the National Academy of Sciences.

[148]  Marie Evangelista,et al.  Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation , 2010, Molecular and Cellular Biology.

[149]  Randy J. Read,et al.  Acta Crystallographica Section D Biological , 2003 .

[150]  S. Angers,et al.  G Protein βγ Subunits Regulate Cell Adhesion through Rap1a and Its Effector Radil , 2010, The Journal of Biological Chemistry.

[151]  S. Pons,et al.  Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base , 2010, Journal of Cell Science.

[152]  P. Beachy,et al.  Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus , 2009, Proceedings of the National Academy of Sciences.

[153]  P. De Camilli,et al.  Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. , 2009, Developmental cell.

[154]  Robert W. Burgess,et al.  Rab3 Dynamically Controls Protein Composition at Active Zones , 2009, Neuron.

[155]  H. Bellen,et al.  Rab3 GTPase Lands Bruchpilot , 2009, Neuron.

[156]  M. McNiven,et al.  Src-Mediated Phosphorylation of Dynamin and Cortactin Regulates the “Constitutive” Endocytosis of Transferrin , 2009, Molecular and Cellular Biology.

[157]  Harel Weinstein,et al.  Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD , 2009, Proceedings of the National Academy of Sciences.

[158]  F. Wouters,et al.  Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans , 2009, Proceedings of the National Academy of Sciences.

[159]  K. Verhey,et al.  Traffic control: regulation of kinesin motors , 2009, Nature Reviews Molecular Cell Biology.

[160]  E. Buchner,et al.  Bruchpilot in Ribbon-Like Axonal Agglomerates, Behavioral Defects, and Early Death in SRPK79D Kinase Mutants of Drosophila , 2009, PLoS genetics.

[161]  Marcel Mettlen,et al.  Dissecting dynamin's role in clathrin-mediated endocytosis. , 2009, Biochemical Society transactions.

[162]  N. Hirokawa,et al.  Kinesin superfamily motor proteins and intracellular transport , 2009, Nature Reviews Molecular Cell Biology.

[163]  Viola Vogel,et al.  Integrin Activation Dynamics between the RGD-binding Site and the Headpiece Hinge* , 2009, The Journal of Biological Chemistry.

[164]  M. Houslay Disrupting specific PDZ domain‐mediated interactions for therapeutic benefit , 2009, British journal of pharmacology.

[165]  R. Fetter,et al.  Negative Regulation of Active Zone Assembly by a Newly Identified SR Protein Kinase , 2009, PLoS biology.

[166]  Bradley T. Hyman,et al.  Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment , 2009, The Journal of cell biology.

[167]  D. Hodzic,et al.  Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections , 2009, The Journal of cell biology.

[168]  D. Loerke,et al.  Global and local regulation of clathrin-coated pit dynamics detected on patterned substrates. , 2009, Biophysical journal.

[169]  J. de Gunzburg,et al.  Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis , 2009, Journal of Cell Science.

[170]  C. Hui,et al.  Cilium – independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved , 2009 .

[171]  Marie Evangelista,et al.  The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development , 2009, Current Biology.

[172]  D. Loerke,et al.  Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. , 2009, Molecular biology of the cell.

[173]  D. Owald,et al.  Maturation of active zone assembly by Drosophila Bruchpilot , 2009, The Journal of cell biology.

[174]  James Briscoe,et al.  The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling , 2009, Science Signaling.

[175]  P. Casey,et al.  Activation of Rap1 promotes prostate cancer metastasis. , 2009, Cancer research.

[176]  Huiqing Zeng,et al.  Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. , 2009, Developmental biology.

[177]  H. McMahon,et al.  Mechanisms of endocytosis. , 2009, Annual review of biochemistry.

[178]  D. Owald,et al.  Assembling the presynaptic active zone , 2009, Current Opinion in Neurobiology.

[179]  Shing-Hwa Liu,et al.  Uropathogenic Escherichia coli-Induced Inflammation Alters Mouse Urinary Bladder Contraction via an Interleukin-6-Activated Inducible Nitric Oxide Synthase-Related Pathway , 2009, Infection and Immunity.

[180]  Michael L. Dustin,et al.  JCB_200809136 521..534 , 2009 .

[181]  H. Deng,et al.  Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. , 2009, Genomics.

[182]  G. Melikyan,et al.  HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes , 2009, Cell.

[183]  M. Czaja,et al.  Autophagy regulates lipid metabolism , 2009, Nature.

[184]  P. Chuang,et al.  Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium , 2009, PloS one.

[185]  Pierre-Alexandre Vidi,et al.  Fluorescent and Bioluminescent Protein-Fragment Complementation Assays in the Study of G Protein-Coupled Receptor Oligomerization and Signaling , 2009, Molecular Pharmacology.

[186]  S. Collins,et al.  Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum , 2009, Science.

[187]  Robert V Farese,et al.  Lipid droplets at a glance , 2009, Journal of Cell Science.

[188]  J. Ward,et al.  Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA , 2009, Development.

[189]  Maulik R. Patel,et al.  RSY-1 Is a Local Inhibitor of Presynaptic Assembly in C. elegans , 2009, Science.

[190]  M. Scott,et al.  Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process , 2009, Proceedings of the National Academy of Sciences.

[191]  Sandra L Schmid,et al.  Cargo and Dynamin Regulate Clathrin-Coated Pit Maturation , 2009, PLoS biology.

[192]  R. Hannoush,et al.  Inhibition of Wnt signaling by Dishevelled PDZ peptides. , 2009, Nature chemical biology.

[193]  F. Leiss,et al.  Characterization of dendritic spines in the Drosophila central nervous system , 2009, Developmental neurobiology.

[194]  A. McMahon,et al.  Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation , 2009, Proceedings of the National Academy of Sciences.

[195]  C. Lim,et al.  RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences* , 2009, Journal of Biological Chemistry.

[196]  D. Baker,et al.  Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation* , 2009, Journal of Biological Chemistry.

[197]  Y. Chen,et al.  Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin–proteasome pathway , 2009, Oncogene.

[198]  D. Huszar,et al.  Kinesin motor proteins as targets for cancer therapy , 2009, Cancer and Metastasis Reviews.

[199]  L. Cornelius,et al.  Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. , 2009, Cancer research.

[200]  T. Tomoda,et al.  Unc-51 Controls Active Zone Density and Protein Composition by Downregulating ERK Signaling , 2009, The Journal of Neuroscience.

[201]  Alexander Borst,et al.  Synaptic Organization of Lobula Plate Tangential Cells in Drosophila: Dα7 Cholinergic Receptors , 2009, Journal of neurogenetics.

[202]  Harry K. Genant,et al.  Application of micro-ct assessment of 3-d bone microstructure in preclinical and clinical studies , 2009, Journal of Bone and Mineral Metabolism.

[203]  B. Geiger,et al.  Environmental sensing through focal adhesions , 2009, Nature Reviews Molecular Cell Biology.

[204]  Noritaka Nishida,et al.  Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. , 2008, Molecular cell.

[205]  Gaudenz Danuser,et al.  Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed , 2008, The Journal of cell biology.

[206]  Hannah B. Gordon,et al.  Clathrin, AP‐2, and the NPXY‐binding subset of alternate endocytic adaptors facilitate FimH‐mediated bacterial invasion of host cells , 2008, Cellular microbiology.

[207]  Travis L. Rodkey,et al.  Munc18a scaffolds SNARE assembly to promote membrane fusion. , 2008, Molecular biology of the cell.

[208]  T. Südhof Neuroligins and neurexins link synaptic function to cognitive disease , 2008, Nature.

[209]  C. Garner,et al.  Molecular mechanisms of presynaptic differentiation. , 2008, Annual review of cell and developmental biology.

[210]  J. Bos,et al.  PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. , 2008, European journal of cell biology.

[211]  Christian Rosenmund,et al.  Supporting Online Material Materials and Methods Som Text Figs. S1 to 12 Tables S1 and S2 References and Notes Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion , 2022 .

[212]  G. Karsenty Transcriptional control of skeletogenesis. , 2008, Annual review of genomics and human genetics.

[213]  Chris Sander,et al.  A Specificity Map for the PDZ Domain Family , 2008, PLoS biology.

[214]  Timothy A. Springer,et al.  Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3 , 2008, The Journal of cell biology.

[215]  J. York,et al.  A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation , 2008, Proceedings of the National Academy of Sciences.

[216]  G. Blobel,et al.  A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to Microtubules , 2008, Cell.

[217]  K. Jaqaman,et al.  Robust single particle tracking in live cell time-lapse sequences , 2008, Nature Methods.

[218]  B. Dhakal,et al.  Mechanisms and consequences of bladder cell invasion by uropathogenic Escherichia coli , 2008, European journal of clinical investigation.

[219]  C. Harris,et al.  The chemical biology of nitric oxide: implications in cellular signaling. , 2008, Free radical biology & medicine.

[220]  Jane A. Yu,et al.  JAWS coordinates chondrogenesis and synovial joint positioning , 2008, Development.

[221]  J. Rizo,et al.  Synaptic vesicle fusion , 2008, Nature Structural &Molecular Biology.

[222]  R. Lefkowitz,et al.  β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium , 2008, Science.

[223]  J. Bos,et al.  cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics. , 2008, Cellular signalling.

[224]  S. Mackem,et al.  Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy , 2008, Development.

[225]  Tobias M. Rasse,et al.  Activity-dependent site-specific changes of glutamate receptor composition in vivo , 2008, Nature Neuroscience.

[226]  R. Schwabe,et al.  Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis* , 2008, Journal of Biological Chemistry.

[227]  I. Dulubova,et al.  NMR analysis of the closed conformation of syntaxin-1 , 2008, Journal of biomolecular NMR.

[228]  Dirk Fasshauer,et al.  Munc18a controls SNARE assembly through its interaction with the syntaxin N‐peptide , 2008, The EMBO journal.

[229]  Christopher M Hickey,et al.  HOPS proofreads the trans-SNARE complex for yeast vacuole fusion. , 2008, Molecular biology of the cell.

[230]  M. Duncan,et al.  Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasion. , 2008, Cancer research.

[231]  M. Howarth,et al.  Imaging proteins in live mammalian cells with biotin ligase and monovalent streptavidin , 2008, Nature Protocols.

[232]  A. Brunger,et al.  Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1:1 syntaxin/SNAP-25 complex. , 2008, Structure.

[233]  K. Shen,et al.  Building a synapse: lessons on synaptic specificity and presynaptic assembly from the nematode C. elegans , 2008, Current Opinion in Neurobiology.

[234]  B. Conklin,et al.  Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass , 2008, Proceedings of the National Academy of Sciences.

[235]  J. Rizo,et al.  Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes. , 2008, Biochemistry.

[236]  B. Finlay,et al.  Invasive and adherent bacterial pathogens co-Opt host clathrin for infection. , 2008, Nature Reviews Microbiology.

[237]  D. Kern,et al.  Dynamic personalities of proteins , 2007, Nature.

[238]  K. Moelling,et al.  c-Src-Mediated Epithelial Cell Migration and Invasion Regulated by PDZ Binding Site , 2007, Molecular and Cellular Biology.

[239]  Josep Rizo,et al.  Dual Modes of Munc18-1/SNARE Interactions Are Coupled by Functionally Critical Binding to Syntaxin-1 N Terminus , 2007, The Journal of Neuroscience.

[240]  Z. Werb,et al.  Role of Matrix Metalloproteinase 13 in Both Endochondral and Intramembranous Ossification during Skeletal Regeneration , 2007, PloS one.

[241]  R. Gautier,et al.  Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein‐1 , 2007, The FEBS journal.

[242]  M. Ginsberg,et al.  KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions , 2007, The Journal of cell biology.

[243]  M. Shimaoka,et al.  Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling , 2007 .

[244]  Yan Leng,et al.  Abelson Interactor Protein-1 Positively Regulates Breast Cancer Cell Proliferation, Migration, and Invasion , 2007, Molecular Cancer Research.

[245]  V. Budnik,et al.  Crucial Role of Drosophila Neurexin in Proper Active Zone Apposition to Postsynaptic Densities, Synaptic Growth, and Synaptic Transmission , 2007, Neuron.

[246]  A. Look,et al.  A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. , 2007, Genes & development.

[247]  S. Majumdar,et al.  IGF‐I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on Bone , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[248]  M. Scott,et al.  Patching the gaps in Hedgehog signalling , 2007, Nature Cell Biology.

[249]  Attila Gulyás-Kovács,et al.  Munc18-1: Sequential Interactions with the Fusion Machinery Stimulate Vesicle Docking and Priming , 2007, The Journal of Neuroscience.

[250]  D. Dickman,et al.  A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport , 2007, Nature Neuroscience.

[251]  M. Feldman,et al.  Downregulation of Rap1GAP Contributes to Ras Transformation , 2007, Molecular and Cellular Biology.

[252]  M. Scott,et al.  Patched 1 Regulates Hedgehog Signaling at the Primary Cilium , 2022 .

[253]  Randy J. Read,et al.  Phaser crystallographic software , 2007, Journal of applied crystallography.

[254]  Paul Greengard,et al.  Three-Dimensional Architecture of Presynaptic Terminal Cytomatrix , 2007, The Journal of Neuroscience.

[255]  K. Moelling,et al.  Regulation of c‐Src by binding to the PDZ domain of AF‐6 , 2007, The EMBO journal.

[256]  Min Han,et al.  SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. , 2007, Developmental cell.

[257]  T. Corson,et al.  KIF14 Messenger RNA Expression Is Independently Prognostic for Outcome in Lung Cancer , 2007, Clinical Cancer Research.

[258]  E. Bruyneel,et al.  The tandem PDZ domains of syntenin promote cell invasion. , 2007, Experimental cell research.

[259]  M. Bissell,et al.  Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. , 2007, Cancer research.

[260]  Matthew W. Foster,et al.  Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2 , 2007, Cell.

[261]  Jack Snoeyink,et al.  MolProbity: all-atom contacts and structure validation for proteins and nucleic acids , 2007, Nucleic Acids Res..

[262]  T. Springer,et al.  Tests of the Extension and Deadbolt Models of Integrin Activation* , 2007, Journal of Biological Chemistry.

[263]  G. Palù,et al.  Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef , 2007, Proceedings of the National Academy of Sciences.

[264]  B. Bishop,et al.  Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells , 2007, Nature Medicine.

[265]  Richard A. Firtel,et al.  Rap1 controls cell adhesion and cell motility through the regulation of myosin II , 2007, The Journal of cell biology.

[266]  S. Nelson,et al.  Oxysterols Are Novel Activators of the Hedgehog Signaling Pathway in Pluripotent Mesenchymal Cells* , 2007, Journal of Biological Chemistry.

[267]  C. Carman,et al.  Structural basis of integrin regulation and signaling. , 2007, Annual review of immunology.

[268]  John G. Collard,et al.  The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization , 2007, The Journal of cell biology.

[269]  Guillermo Ayala,et al.  Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate , 2007, Proceedings of the National Academy of Sciences.

[270]  T. Südhof,et al.  Munc18-1 binds directly to the neuronal SNARE complex , 2007, Proceedings of the National Academy of Sciences.

[271]  C. Tifft,et al.  Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta , 2007, Nature Genetics.

[272]  D. Mukhopadhyay,et al.  Nitric oxide promotes endothelial cell survival signaling through S-nitrosylation and activation of dynamin-2 , 2007, Journal of Cell Science.

[273]  Aaron DiAntonio,et al.  Synaptic Development: Insights from Drosophila This Review Comes from a Themed Issue on Development Edited Synapse Development Live Imaging of Glutamate Receptor Clustering Synaptic Terminal Development Synaptic Terminal Stability , 2022 .

[274]  J. Rothman,et al.  Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins , 2007, Cell.

[275]  Jun Zhang,et al.  Exploring membrane domains using native membrane sheets and transmission electron microscopy. , 2007, Methods in molecular biology.

[276]  M. Arnaout,et al.  The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. , 2007, Blood.

[277]  Guoyao Wu,et al.  Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. , 2007, Cancer research.

[278]  Vijay H Shah,et al.  Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking , 2006, Proceedings of the National Academy of Sciences.

[279]  E. Réal,et al.  Analysis of synaptic ultrastructure without fixative using high‐pressure freezing and tomography , 2006, The European journal of neuroscience.

[280]  Maulik R. Patel,et al.  Hierarchical assembly of presynaptic components in defined C. elegans synapses , 2006, Nature Neuroscience.

[281]  K. Lilley,et al.  Comparative proteomics of clathrin-coated vesicles , 2006, The Journal of cell biology.

[282]  M. Nonet,et al.  SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS , 2006, Nature Neuroscience.

[283]  L. Luo,et al.  A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining , 2006, Nature Protocols.

[284]  Klaus Schulten,et al.  How the headpiece hinge angle is opened: new insights into the dynamics of integrin activation , 2006, The Journal of cell biology.

[285]  F. Glorieux,et al.  CRTAP Is Required for Prolyl 3- Hydroxylation and Mutations Cause Recessive Osteogenesis Imperfecta , 2006, Cell.

[286]  G. Parmigiani,et al.  The Consensus Coding Sequences of Human Breast and Colorectal Cancers , 2006, Science.

[287]  M. Zastrow,et al.  Cargo Regulates Clathrin-Coated Pit Dynamics , 2006, Cell.

[288]  Katherine L. Wilson,et al.  SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton , 2006, Nature Reviews Molecular Cell Biology.

[289]  Simon C Watkins,et al.  A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors. , 2006, Molecular biology of the cell.

[290]  Thomas C. Südhof,et al.  A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis , 2006, Cell.

[291]  S. Gross,et al.  The Lipid-Droplet Proteome Reveals that Droplets Are a Protein-Storage Depot , 2006, Current Biology.

[292]  S. Hultgren,et al.  Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract , 2006, Proceedings of the National Academy of Sciences.

[293]  O. Kotoulas,et al.  Glycogen autophagy in glucose homeostasis. , 2006, Pathology, research and practice.

[294]  T. Corson,et al.  KIF14 mRNA expression is a predictor of grade and outcome in breast cancer , 2006, International journal of cancer.

[295]  K. Gaus,et al.  Identification and Characterization of Associated with Lipid Droplet Protein 1: A Novel Membrane‐Associated Protein That Resides on Hepatic Lipid Droplets , 2006, Traffic.

[296]  Reinhard Jahn,et al.  SNAREs — engines for membrane fusion , 2006, Nature Reviews Molecular Cell Biology.

[297]  Eckart D. Gundelfinger,et al.  Molecular organization of the presynaptic active zone , 2006, Cell and Tissue Research.

[298]  Demet Araç,et al.  Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release. , 2006, Trends in cell biology.

[299]  R. Lipinski,et al.  Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling. , 2006, Experimental cell research.

[300]  T. Südhof,et al.  Structural Determinants of Synaptobrevin 2 Function in Synaptic Vesicle Fusion , 2006, The Journal of Neuroscience.

[301]  Lindsay N. Carpp,et al.  The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes , 2006, The Journal of cell biology.

[302]  H. Hauri,et al.  Morphogenesis of the Endoplasmic Reticulum: Beyond Active Membrane Expansion , 2006, Traffic.

[303]  M. Scott,et al.  Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[304]  Stephan J. Sigrist,et al.  Bruchpilot Promotes Active Zone Assembly, Ca2+ Channel Clustering, and Vesicle Release , 2006, Science.

[305]  Peter S. Linsley,et al.  RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure , 2006, Molecular and Cellular Biology.

[306]  T. Natsume,et al.  Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein. , 2006, Journal of biochemistry.

[307]  A. Joyner,et al.  Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation , 2006, Molecular and Cellular Biology.

[308]  Kevin M. Collins,et al.  Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p , 2006, The EMBO journal.

[309]  C. Lively,et al.  Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. , 2006, Molecular biology of the cell.

[310]  Pieter C Dorrestein,et al.  A monovalent streptavidin with a single femtomolar biotin binding site , 2006, Nature Methods.

[311]  Stephan J. Sigrist,et al.  Bruchpilot, a Protein with Homology to ELKS/CAST, Is Required for Structural Integrity and Function of Synaptic Active Zones in Drosophila , 2006, Neuron.

[312]  Michael J Rust,et al.  Ligands for Clathrin-Mediated Endocytosis Are Differentially Sorted into Distinct Populations of Early Endosomes , 2006, Cell.

[313]  H. Aberle,et al.  The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain. , 2006, Gene expression patterns : GEP.

[314]  P. Cossart,et al.  Bacterial Adhesion and Entry into Host Cells , 2006, Cell.

[315]  M. Lauth,et al.  Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. , 2006, Developmental cell.

[316]  Erich A. Nigg,et al.  KIF14 and citron kinase act together to promote efficient cytokinesis , 2006, The Journal of cell biology.

[317]  J. Stamler,et al.  Nitric oxide regulates endocytosis by S-nitrosylation of dynamin , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[318]  T. Michel,et al.  The regulation and pharmacology of endothelial nitric oxide synthase. , 2006, Annual review of pharmacology and toxicology.

[319]  K. Anderson,et al.  Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates , 2006, Development.

[320]  A. Diantonio Glutamate receptors at the Drosophila neuromuscular junction. , 2006, International review of neurobiology.

[321]  N. Watanabe,et al.  Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. , 2006, Current biology : CB.

[322]  Yanyun Li,et al.  Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[323]  P. Evans,et al.  Scaling and assessment of data quality. , 2006, Acta crystallographica. Section D, Biological crystallography.

[324]  D. Featherstone,et al.  Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants , 2005, BMC Biology.

[325]  D. Kalderon The mechanism of hedgehog signal transduction. , 2005, Biochemical Society transactions.

[326]  Didier Y. R. Stainier,et al.  Vertebrate Smoothened functions at the primary cilium , 2005, Nature.

[327]  C. Hui,et al.  Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. , 2005, Differentiation; research in biological diversity.

[328]  K. Katagiri,et al.  Regulation of immune cell adhesion and migration by regulator of adhesion and cell polarization enriched in lymphoid tissues , 2005, Immunology.

[329]  M. Brueckner,et al.  Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused , 2005, Development.

[330]  Qihong Zhang,et al.  Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function , 2005, PLoS genetics.

[331]  R. Chadwick,et al.  Spontaneous Fractures in the Mouse Mutant sfx Are Caused by Deletion of the Gulonolactone Oxidase Gene, Causing Vitamin C Deficiency , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[332]  Ralf Schneggenburger,et al.  A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? , 2005, The EMBO journal.

[333]  K. Anderson,et al.  Cilia and Hedgehog responsiveness in the mouse. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[334]  J. Chrivia,et al.  Human SRCAP and Drosophila melanogaster DOM Are Homologs That Function in the Notch Signaling Pathway , 2005, Molecular and Cellular Biology.

[335]  Timothy W Corson,et al.  KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers , 2005, Oncogene.

[336]  Neil O. Carragher,et al.  The role of focal-adhesion kinase in cancer — a new therapeutic opportunity , 2005, Nature Reviews Cancer.

[337]  Tobias M. Rasse,et al.  Glutamate receptor dynamics organizing synapse formation in vivo , 2005, Nature Neuroscience.

[338]  Masakazu Kikuchi,et al.  Electron tomography reveals diverse conformations of integrin αIIbβ3 in the active state , 2005 .

[339]  M. Smyth,et al.  A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. , 2005, Immunity.

[340]  C. Tacchetti,et al.  Relationships between EGFR signaling-competent and endocytosis-competent membrane microdomains. , 2005, Molecular Biology of the Cell.

[341]  Michael Krauss,et al.  Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2. , 2005, Molecular cell.

[342]  P. Roughley,et al.  FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice , 2005, The Journal of cell biology.

[343]  Kevin M. Collins,et al.  Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion , 2005, The EMBO journal.

[344]  J. Bos Linking Rap to cell adhesion. , 2005, Current opinion in cell biology.

[345]  Mark Yeager,et al.  Three-dimensional EM structure of the ectodomain of integrin αVβ3 in a complex with fibronectin , 2005, The Journal of cell biology.

[346]  Tobias M. Rasse,et al.  Four Different Subunits Are Essential for Expressing the Synaptic Glutamate Receptor at Neuromuscular Junctions of Drosophila , 2005, The Journal of Neuroscience.

[347]  N. Mochizuki,et al.  Local Activation of Rap1 Contributes to Directional Vascular Endothelial Cell Migration Accompanied by Extension of Microtubules on Which RAPL, a Rap1-associating Molecule, Localizes* , 2005, Journal of Biological Chemistry.

[348]  H. E. Marshall,et al.  Protein S-nitrosylation: purview and parameters , 2005, Nature Reviews Molecular Cell Biology.

[349]  M. Howarth,et al.  Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase , 2005, Nature Methods.

[350]  Axel T Brunger,et al.  Structure and function of SNARE and SNARE-interacting proteins , 2005, Quarterly Reviews of Biophysics.

[351]  D. Van Vactor,et al.  Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles. , 2005, Current biology : CB.

[352]  Kevin Cowtan,et al.  research papers Acta Crystallographica Section D Biological , 2005 .

[353]  Aaron DiAntonio,et al.  Increased Expression of the Drosophila Vesicular Glutamate Transporter Leads to Excess Glutamate Release and a Compensatory Decrease in Quantal Content , 2004, The Journal of Neuroscience.

[354]  Barry S. Coller,et al.  Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics , 2004, Nature.

[355]  C. Hernandez,et al.  Osteocyte density in woven bone. , 2004, Bone.

[356]  K. Schulten,et al.  Structural insights into how the MIDAS ion stabilizes integrin binding to an RGD peptide under force. , 2004, Structure.

[357]  Jonathan A. Cooper,et al.  Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors , 2004, The Journal of cell biology.

[358]  M. Ultsch,et al.  Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism , 2004, Molecular and Cellular Biology.

[359]  G. Freeman,et al.  RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. , 2004, Developmental cell.

[360]  M. Sheng,et al.  PDZ domain proteins of synapses , 2004, Nature Reviews Neuroscience.

[361]  S. Hultgren,et al.  Host subversion by formation of intracellular bacterial communities in the urinary tract. , 2004, Microbes and infection.

[362]  K. Chandran,et al.  Endocytosis by Random Initiation and Stabilization of Clathrin-Coated Pits , 2004, Cell.

[363]  P. Schultz,et al.  Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. , 2004, Chemistry & biology.

[364]  C. Rosen Insulin-like growth factor I and bone mineral density: experience from animal models and human observational studies. , 2004, Best practice & research. Clinical endocrinology & metabolism.

[365]  H. Vogel,et al.  Labeling of fusion proteins with synthetic fluorophores in live cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[366]  G. Nolan,et al.  A general approach for chemical labeling and rapid, spatially controlled protein inactivation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[367]  Junichi Takagi,et al.  Allosteric β1 Integrin Antibodies That Stabilize the Low Affinity State by Preventing the Swing-out of the Hybrid Domain* , 2004, Journal of Biological Chemistry.

[368]  Lawrence Lum,et al.  The Hedgehog Response Network: Sensors, Switches, and Routers , 2004, Science.

[369]  G. Crooks,et al.  WebLogo: a sequence logo generator. , 2004, Genome research.

[370]  M. Humphries,et al.  Novel activating and inactivating mutations in the integrin beta1 subunit A domain. , 2004, The Biochemical journal.

[371]  J. Takagi,et al.  A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand , 2004, PLoS biology.

[372]  S. Tam,et al.  UR-3216: a new generation oral platelet GPIIb/IIIa antagonist. , 2004, Current pharmaceutical design.

[373]  J. Carson,et al.  Bacterial Penetration of Bladder Epithelium through Lipid Rafts* , 2004, Journal of Biological Chemistry.

[374]  K. Katagiri,et al.  Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL. , 2004, Immunology letters.

[375]  P. Sassone-Corsi,et al.  ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology Implication for Coffin-Lowry Syndrome , 2004, Cell.

[376]  J. Takagi,et al.  Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides. , 2004, The Journal of biological chemistry.

[377]  D. Curtis,et al.  Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome , 2004, Nature Genetics.

[378]  M. Shimaoka,et al.  Activation of integrin β-subunit I-like domains by one-turn C-terminal α-helix deletions , 2004 .

[379]  A. Diantonio,et al.  Differential Localization of Glutamate Receptor Subunits at the Drosophila Neuromuscular Junction , 2004, The Journal of Neuroscience.

[380]  Y. Higashi,et al.  Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. , 2004, Biochimica et biophysica acta.

[381]  B. Felding-Habermann,et al.  Integrin adhesion receptors in tumor metastasis , 2004, Clinical & Experimental Metastasis.

[382]  B. Sykes,et al.  Homozygous osteogenesis imperfecta unlinked to collagen I genes , 1988, Human Genetics.

[383]  K. Kivirikko,et al.  Collagens, modifying enzymes and their mutations in humans, flies and worms. , 2004, Trends in genetics : TIG.

[384]  T. Sudhof,et al.  The synaptic vesicle cycle. , 2004, Annual review of neuroscience.

[385]  L. Lum,et al.  Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. , 2003, Molecular cell.

[386]  P. McEwan,et al.  Structure of an Integrin-Ligand Complex Deduced from Solution X-ray Scattering and Site-directed Mutagenesis* , 2003, Journal of Biological Chemistry.

[387]  Minsoo Kim,et al.  Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins , 2003, Science.

[388]  Jill A. Helms,et al.  Altered fracture repair in the absence of MMP9 , 2003, Development.

[389]  Stephan J Sigrist,et al.  Experience-Dependent Strengthening of Drosophila Neuromuscular Junctions , 2003, The Journal of Neuroscience.

[390]  K. Katagiri,et al.  RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1 , 2003, Nature Immunology.

[391]  H. Richardson,et al.  Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[392]  David L. Lacey,et al.  Osteoclast differentiation and activation , 2003, Nature.

[393]  P. McEwan,et al.  Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement* , 2003, The Journal of Biological Chemistry.

[394]  M. Verhage,et al.  Vesicle trafficking: pleasure and pain from SM genes. , 2003, Trends in cell biology.

[395]  R. Weinberg,et al.  Association of the Kinesin Motor KIF1A with the Multimodular Protein Liprin-α* , 2003, The Journal of Biological Chemistry.

[396]  K. Mechtler,et al.  The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl , 2003, Nature.

[397]  J. Rizo,et al.  Facile detection of protein-protein interactions by one-dimensional NMR spectroscopy. , 2003, Biochemistry.

[398]  M. Young Bone matrix proteins: their function, regulation, and relationship to osteoporosis , 2003, Osteoporosis International.

[399]  Sandra L. Schmid,et al.  Regulated portals of entry into the cell , 2003, Nature.

[400]  J. Takagi,et al.  Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[401]  J. Bos,et al.  The role of Rap1 in integrin-mediated cell adhesion. , 2001, Biochemical Society transactions.

[402]  S. Dedhar,et al.  alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells. , 2003, Oncogene.

[403]  T. Südhof,et al.  Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[404]  W. Weissenhorn,et al.  Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p , 2002, The EMBO journal.

[405]  H. Wichterle,et al.  Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists , 2002, Journal of biology.

[406]  S. Hallam,et al.  SYD-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains, specifies axon identity in C. elegans , 2002, Nature Neuroscience.

[407]  Jussi Taipale,et al.  Small molecule modulation of Smoothened activity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[408]  Alexey I Nesvizhskii,et al.  Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. , 2002, Analytical chemistry.

[409]  Diane Hu,et al.  A model for intramembranous ossification during fracture healing , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[410]  Mohammad Hassan Qureshi,et al.  Design, production, and characterization of a monomeric streptavidin and its application for affinity purification of biotinylated proteins. , 2002, Protein expression and purification.

[411]  Thomas C. Südhof,et al.  Snares and munc18 in synaptic vesicle fusion , 2002, Nature Reviews Neuroscience.

[412]  T. Südhof,et al.  How Tlg2p/syntaxin 16 'snares’ Vps45 , 2002, The EMBO journal.

[413]  F. Glorieux,et al.  Osteogenesis imperfecta type VII: an autosomal recessive form of brittle bone disease. , 2002, Bone.

[414]  Irina Kaverina,et al.  Regulation of substrate adhesion dynamics during cell motility. , 2002, The international journal of biochemistry & cell biology.

[415]  D. Gallwitz,et al.  Sly1 protein bound to Golgi syntaxin Sed5p allows assembly and contributes to specificity of SNARE fusion complexes , 2002, The Journal of cell biology.

[416]  Robert E Campbell,et al.  New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. , 2002, Journal of the American Chemical Society.

[417]  M. Mulvey,et al.  Adhesion and entry of uropathogenic Escherichia coli , 2002, Cellular microbiology.

[418]  E. Wagner,et al.  Reaching a genetic and molecular understanding of skeletal development. , 2002, Developmental cell.

[419]  Thilo Stehle,et al.  Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand , 2002, Science.

[420]  T. Südhof,et al.  Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. , 2002, Developmental cell.

[421]  N. Hogg,et al.  Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling , 2002, Nature Immunology.

[422]  I. Gaidarov,et al.  G protein–coupled receptor/arrestin3 modulation of the endocytic machinery , 2002, The Journal of cell biology.

[423]  T. Südhof,et al.  Three-Dimensional Structure of the Complexin/SNARE Complex , 2002, Neuron.

[424]  J. Small,et al.  Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1 , 2002, The Journal of cell biology.

[425]  F. Glorieux,et al.  Osteogenesis Imperfecta Type VI: A Form of Brittle Bone Disease with a Mineralization Defect , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[426]  D. Van Vactor,et al.  Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. , 2002, Neuron.

[427]  R. Weinberg,et al.  Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. , 2002, Neuron.

[428]  W. Lim,et al.  Mechanism and role of PDZ domains in signaling complex assembly. , 2001, Journal of cell science.

[429]  Paul Scherz,et al.  Functional analysis of secreted and transmembrane proteins critical to mouse development , 2001, Nature Genetics.

[430]  S. Hultgren,et al.  Establishment of a Persistent Escherichia coli Reservoir during the Acute Phase of a Bladder Infection , 2001, Infection and Immunity.

[431]  D. Power,et al.  Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase* , 2001, The Journal of Biological Chemistry.

[432]  W. Sessa,et al.  Direct Interaction between Endothelial Nitric-oxide Synthase and Dynamin-2 , 2001, The Journal of Biological Chemistry.

[433]  M. Sheng,et al.  PDZ domains and the organization of supramolecular complexes. , 2001, Annual review of neuroscience.

[434]  T. Südhof,et al.  Vam3p structure reveals conserved and divergent properties of syntaxins , 2001, Nature Structural Biology.

[435]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[436]  J W Smith,et al.  Integrin activation controls metastasis in human breast cancer. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[437]  Thomas C. Südhof,et al.  Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release , 2001, Cell.

[438]  H. Sissons,et al.  Fibrogenesis imperfecta ossium (Baker's disease): a case studied at autopsy. , 2000, Bone.

[439]  J. Sobel,et al.  Urinary tract infection: self-reported incidence and associated costs. , 2000, Annals of epidemiology.

[440]  P. Novick,et al.  Ordering the Final Events in Yeast Exocytosis , 2000, The Journal of cell biology.

[441]  N. Méthot,et al.  Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. , 2000, Development.

[442]  F. Glorieux,et al.  Type V Osteogenesis Imperfecta: A New Form of Brittle Bone Disease , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[443]  M. Scott,et al.  Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine , 2000, Nature.

[444]  L. Van Aelst,et al.  The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[445]  T. Südhof,et al.  Selective Interaction of Complexin with the Neuronal SNARE Complex , 2000, The Journal of Biological Chemistry.

[446]  M. McNiven,et al.  Disruption of Golgi structure and function in mammalian cells expressing a mutant dynamin. , 2000, Journal of cell science.

[447]  E. Rosen,et al.  Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes , 2000, Journal of Molecular Medicine.

[448]  Richard H. Scheller,et al.  Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex , 2000, Nature.

[449]  Philip A Beachy,et al.  Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb , 2000, Cell.

[450]  T. Südhof,et al.  Synaptic assembly of the brain in the absence of neurotransmitter secretion. , 2000, Science.

[451]  Jonathan Reeve,et al.  Osteocyte function, osteocyte death and bone fracture resistance , 2000, Molecular and Cellular Endocrinology.

[452]  R. Scheller,et al.  Nsec1 Binds a Closed Conformation of Syntaxin1a , 2000, The Journal of cell biology.

[453]  S. Kuwada,et al.  Integrin alpha5/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation. , 2000, Molecular biology of the cell.

[454]  D. Beckett,et al.  A minimal peptide substrate in biotin holoenzyme synthetase‐catalyzed biotinylation , 2008, Protein science : a publication of the Protein Society.

[455]  M. Nakafuku,et al.  Mouse Suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1 , 1999, Current Biology.

[456]  J. Bateman,et al.  Procollagen folding and assembly: the role of endoplasmic reticulum enzymes and molecular chaperones. , 1999, Seminars in cell & developmental biology.

[457]  D. Kalderon,et al.  Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. , 1999, Development.

[458]  D. Krause,et al.  Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1 , 1999, Nature Cell Biology.

[459]  Theodore Miclau,et al.  Does adult fracture repair recapitulate embryonic skeletal formation? , 1999, Mechanisms of Development.

[460]  T. Südhof,et al.  A conformational switch in syntaxin during exocytosis: role of munc18 , 1999, The EMBO journal.

[461]  P. Roberson,et al.  Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. , 1999, The Journal of clinical investigation.

[462]  M. Scott,et al.  Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators. , 1999, Developmental biology.

[463]  P. Novick,et al.  Sec1p Binds to Snare Complexes and Concentrates at Sites of Secretion , 1999, The Journal of cell biology.

[464]  A. Sorkin,et al.  Inhibition of the receptor‐binding function of clathrin adaptor protein AP‐2 by dominant‐negative mutant μ2 subunit and its effects on endocytosis , 1999, The EMBO journal.

[465]  Yasunori Tanaka,et al.  Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3* , 1999, The Journal of Biological Chemistry.

[466]  James M. Anderson,et al.  PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. , 1999, The Journal of clinical investigation.

[467]  J. Albanesi,et al.  Essential Role of the Dynamin Pleckstrin Homology Domain in Receptor-Mediated Endocytosis , 1999, Molecular and Cellular Biology.

[468]  K. Fiebig,et al.  Folding intermediates of SNARE complex assembly , 1999, Nature Structural Biology.

[469]  S. Schmid,et al.  Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms , 1998, The Journal of cell biology.

[470]  D. Kalderon,et al.  Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator , 1998, Nature.

[471]  A. Wittinghofer,et al.  Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP , 1998, Nature.

[472]  Reinhard Jahn,et al.  Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution , 1998, Nature.

[473]  M. von Zastrow,et al.  Regulated Endocytosis of G-protein-coupled Receptors by a Biochemically and Functionally Distinct Subpopulation of Clathrin-coated Pits* , 1998, The Journal of Biological Chemistry.

[474]  Josep Ubach,et al.  Three-Dimensional Structure of an Evolutionarily Conserved N-Terminal Domain of Syntaxin 1A , 1998, Cell.

[475]  W. Xiao,et al.  The synaptic SNARE complex is a parallel four-stranded helical bundle , 1998, Nature Structural Biology.

[476]  Frederick M. Hughson,et al.  Regulation of SNARE complex assembly by an N-terminal domain of the t-SNARE Sso1p , 1998, Nature Structural Biology.

[477]  M. McNiven,et al.  Differential distribution of dynamin isoforms in mammalian cells. , 1998, Molecular biology of the cell.

[478]  R. A. Warren,et al.  Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs* , 1998, The Journal of Biological Chemistry.

[479]  A. R. I. Altaba Combinatorial Gli Gene Function in Floor Plate and Neuronal Inductions by Sonic Hedgehog , 1998 .

[480]  W. Sessa,et al.  Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. , 1998, The Journal of pharmacology and experimental therapeutics.

[481]  K. Howell,et al.  Role of dynamin in the formation of transport vesicles from the trans-Golgi network. , 1998, Science.

[482]  S. Shenolikar,et al.  The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. , 1998, Nature.

[483]  J. Littleton,et al.  ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage‐dependent manner , 1998, The EMBO journal.

[484]  C. Goodman,et al.  Genetic Analysis of Glutamate Receptors in Drosophila Reveals a Retrograde Signal Regulating Presynaptic Transmitter Release , 1997, Neuron.

[485]  S. Schmid,et al.  Ubiquitously expressed dynamin-II has a higher intrinsic GTPase activity and a greater propensity for self-assembly than neuronal dynamin-I. , 1997, Molecular biology of the cell.

[486]  Y. Jan,et al.  Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[487]  S. Atwell,et al.  Structural plasticity in a remodeled protein-protein interface. , 1997, Science.

[488]  Reinhard Jahn,et al.  Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy , 1997, Cell.

[489]  R. Kobayashi,et al.  Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2 , 1997, Cell.

[490]  T. Kornberg,et al.  Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor , 1997, Cell.

[491]  J. Vasiliev,et al.  KINESIN‐ASSOCIATED TRANSPORT IS INVOLVED IN THE REGULATION OF CELL ADHESION , 1997, Cell biology international.

[492]  K. Kaibuchi,et al.  Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase , 1997, Science.

[493]  R. A. Warren,et al.  Saturation of the Endocytic Pathway for the Transferrin Receptor Does Not Affect the Endocytosis of the Epidermal Growth Factor Receptor* , 1997, The Journal of Biological Chemistry.

[494]  G. Garcı́a-Cardeña,et al.  Bacterial infection induces nitric oxide synthase in human neutrophils. , 1997, The Journal of clinical investigation.

[495]  C. Tabin,et al.  Biochemical evidence that Patched is the Hedgehog receptor , 1996, Nature.

[496]  M. Scott,et al.  The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog , 1996, Nature.

[497]  N. Wiklund,et al.  Elevated nitric oxide in the urinary bladder in infectious and noninfectious cystitis. , 1996, Urology.

[498]  C. Svanborg,et al.  Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[499]  M. Scott,et al.  Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. , 1996, Development.

[500]  P. Ingham,et al.  Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. , 1996, Development.

[501]  P. Ingham,et al.  Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. , 1996, Genes & development.

[502]  P. Watson,et al.  The NCIC-Manitoba Breast Tumor Bank: a resource for applied cancer research. , 1996, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[503]  M. Noll,et al.  The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal , 1996, Cell.

[504]  K. Burridge,et al.  Rho-stimulated contractility drives the formation of stress fibers and focal adhesions , 1996, The Journal of cell biology.

[505]  A. Shevchenko,et al.  Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. , 1996, Analytical chemistry.

[506]  F. Wurm,et al.  Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. , 1996, Nucleic acids research.

[507]  Thomas C. Südhof,et al.  Complexins: Cytosolic proteins that regulate SNAP receptor function , 1995, Cell.

[508]  J. Bonifacino,et al.  Interaction of tyrosine-based sorting signals with clathrin-associated proteins. , 1995, Science.

[509]  R. Beddington,et al.  Capturing genes encoding membrane and secreted proteins important for mouse development. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[510]  F. Maxfield,et al.  Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment , 1995, The Journal of cell biology.

[511]  G. Struhl,et al.  Protein kinase A and hedgehog signaling in drosophila limb development , 1995, Cell.

[512]  Mary Ellen Lane,et al.  Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development , 1995, Cell.

[513]  Susan M. Parkhurst,et al.  Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning , 1995, Nature.

[514]  G. Stein,et al.  The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization. , 1995, Experimental cell research.

[515]  J. Yates,et al.  An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database , 1994, Journal of the American Society for Mass Spectrometry.

[516]  Jonathan Pevsner,et al.  Specificity and regulation of a synaptic vesicle docking complex , 1994, Neuron.

[517]  D. Carey,et al.  Localization of a heterotrimeric G protein gamma subunit to focal adhesions and associated stress fibers , 1994, The Journal of cell biology.

[518]  T. Südhof,et al.  Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin , 1993, Nature.

[519]  Mark K. Bennett,et al.  A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion , 1993, Cell.

[520]  I. Trowbridge,et al.  YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis. , 1993, The Journal of biological chemistry.

[521]  Elizabeth J. Robertson,et al.  Role of insulin-like growth factors in embryonic and postnatal growth , 1993, Cell.

[522]  Stephen J. Smith,et al.  Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria , 1993, Nature.

[523]  C. Mathew,et al.  Osteogenesis imperfecta type III: mutations in the type I collagen structural genes, COL1A1 and COL1A2, are not necessarily responsible. , 1993, Journal of medical genetics.

[524]  John A. Robinson,et al.  Growth on type I collagen promotes expression of the osteoblastic phenotype in human osteosarcoma MG‐63 cells , 1992, Journal of cellular physiology.

[525]  G. Stein,et al.  Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation. , 1992, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[526]  A. Ullrich,et al.  Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain. , 1991, The Journal of biological chemistry.

[527]  F. McCormick,et al.  Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21 rap1 , 1991, Cell.

[528]  J. R. Johnson,et al.  Virulence factors in Escherichia coli urinary tract infection , 1991, Clinical Microbiology Reviews.

[529]  T. D. Schneider,et al.  Sequence logos: a new way to display consensus sequences. , 1990, Nucleic acids research.

[530]  K. Krogfelt,et al.  Direct evidence that the FimH protein is the mannose-specific adhesin of Escherichia coli type 1 fimbriae , 1990, Infection and immunity.

[531]  G. Stein,et al.  Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells , 1990, Journal of cellular physiology.

[532]  A. Frelinger,et al.  Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. , 1990, The Journal of biological chemistry.

[533]  N M Green,et al.  Avidin and streptavidin. , 1990, Methods in enzymology.

[534]  M. Pembrey,et al.  Phenotypical features of an unique Irish family with severe autosomal recessive Osteogenesis imperfecta , 1989, Clinical genetics.

[535]  R. Davis,et al.  Comparison of the kinetics of cycling of the transferrin receptor in the presence or absence of bound diferric transferrin. , 1989, The Biochemical journal.

[536]  A. Frelinger,et al.  Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. , 1988, The Journal of biological chemistry.

[537]  A. Ikai,et al.  Conformational changes of alpha-macroglobulin and ovomacroglobulin from the green turtle (Chelonia mydas japonica). , 1988, Journal of biochemistry.

[538]  D A Scudiero,et al.  Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. , 1988, Cancer research.

[539]  L. Parise,et al.  Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified platelet glycoprotein IIb-IIIa. , 1987, The Journal of biological chemistry.

[540]  E Ruoslahti,et al.  The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[541]  C. Watts Rapid endocytosis of the transferrin receptor in the absence of bound transferrin , 1985, The Journal of cell biology.

[542]  M. Greaves,et al.  Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[543]  L. Greene,et al.  Pit formation and rapid changes in surface morphology of sympathetic neurons in response to nerve growth factor , 1981, The Journal of cell biology.

[544]  G. Kreibich,et al.  Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes , 1978, The Journal of cell biology.

[545]  B. Ames,et al.  A method for determining the sedimentation behavior of enzymes: application to protein mixtures. , 1961, The Journal of biological chemistry.

[546]  J. Faber,et al.  Normal table of Xenopus laevis (Daudin). A systematical and chronological survey of the development from the fertilized egg till the end of metamorphosis. , 1956 .

[547]  S. L. Baker Fibrogenesis imperfecta ossium; a generalised disease of bone characterised by defective formation of the collagen fibres of the bone matrix. , 1956, The Journal of bone and joint surgery. British volume.