Translational medicine as a permanent glue and force of clinical medicine and public health: perspectives (1) from 2012 Sino-American symposium on clinical and translational medicine

AbstractsHealth systems globally face challenges and opportunities in balancing quality, access, and cost, where clinical and translational medicine (CTM) should play more important and powerful roles in the identification, development and validation of solutions and strategies. Strategic collaboration can gather global strengths and resources and improve health systems, care delivery, regulations and policies. CTM-driven innovation and development has the potential to achieve step-change improvements across three dimensions. Thus, we have the reasons to believe that CTM will play even more roles in the development of new diagnostics, therapies, healthcare, and policies and SAS-CTM will become more and more important platform to obtain the latest development in CTM internationally and explore new opportunities in the international collaborations.

[1]  R. Califf,et al.  Scientific evidence underlying the ACC/AHA clinical practice guidelines. , 2009, JAMA.

[2]  Xiangdong Wang,et al.  Role of clinical bioinformatics in the development of network-based Biomarkers , 2011, Journal of Clinical Bioinformatics.

[3]  I. Kola,et al.  Can the pharmaceutical industry reduce attrition rates? , 2004, Nature Reviews Drug Discovery.

[4]  J. Scannell,et al.  Diagnosing the decline in pharmaceutical R&D efficiency , 2012, Nature Reviews Drug Discovery.

[5]  G. Trovato Behavior, nutrition and lifestyle in a comprehensive health and disease paradigm: skills and knowledge for a predictive, preventive and personalized medicine , 2012, EPMA Journal.

[6]  Inder M. Verma,et al.  The NIH Roadmap , 2004 .

[7]  In-Hee Lee,et al.  A filter-based feature selection approach for identifying potential biomarkers for lung cancer , 2011, Journal of Clinical Bioinformatics.

[8]  F. Marincola,et al.  Clinical and translational medicine: Integrative and practical science. , 2012, Clinical and Translational Medicine.

[9]  E. Zerhouni,et al.  Medicine. The NIH Roadmap. , 2003, Science.

[10]  Robert M Califf,et al.  The role of academic health science systems in the transformation of medicine , 2010, The Lancet.

[11]  Xiangdong Wang,et al.  Can lung cancer stem cells be targeted for therapies? , 2012, Cancer treatment reviews.

[12]  Mario Plebani,et al.  What's next in translational medicine? , 2007, Clinical science.

[13]  F. Marincola Translational Medicine: A two-way road , 2003, Journal of Translational Medicine.

[14]  Robert M Califf,et al.  Characteristics of clinical trials registered in ClinicalTrials.gov, 2007-2010. , 2012, JAMA.

[15]  Francesco M Marincola,et al.  Translational Medicine is developing in China: A new venue for collaboration , 2011, Journal of Translational Medicine.

[16]  A. Terzic,et al.  Clinical and Translational Science: From Bench‐Bedside to Global Village , 2010, Clinical and translational science.

[17]  M. Day,et al.  Translational medicine--a paradigm shift in modern drug discovery and development: the role of biomarkers. , 2009, Advances in experimental medicine and biology.