Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD

[1]  Naoki Nishishita,et al.  Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors , 2011, Proceedings of the National Academy of Sciences.

[2]  Michel Sadelain,et al.  miR-371-3 expression predicts neural differentiation propensity in human pluripotent stem cells. , 2011, Cell stem cell.

[3]  C. Hartmann,et al.  Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation , 2011, Nature Cell Biology.

[4]  P. Gray,et al.  Development, Maturation, and Necessity of Transcription Factors in the Mouse Suprachiasmatic Nucleus , 2011, The Journal of Neuroscience.

[5]  R. Jaenisch,et al.  Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats , 2010, Proceedings of the National Academy of Sciences.

[6]  M. Tomishima,et al.  Efficient derivation of functional floor plate tissue from human embryonic stem cells. , 2010, Cell stem cell.

[7]  O. Lindvall,et al.  Stem cells in human neurodegenerative disorders--time for clinical translation? , 2010, The Journal of clinical investigation.

[8]  D. James Surmeier,et al.  Robust Pacemaking in Substantia Nigra Dopaminergic Neurons , 2009, The Journal of Neuroscience.

[9]  Kuei Yuan Tseng,et al.  Stepping test in mice: A reliable approach in determining forelimb akinesia in MPTP-induced Parkinsonism , 2009, Experimental Neurology.

[10]  M. Tomishima,et al.  Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling , 2009, Nature Biotechnology.

[11]  Rudolf Jaenisch,et al.  Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors , 2009, Cell.

[12]  M. Taketo,et al.  Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis , 2009, Nature Neuroscience.

[13]  M. Peschanski,et al.  Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats , 2008, Proceedings of the National Academy of Sciences.

[14]  R. Jaenisch,et al.  Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease , 2008, Proceedings of the National Academy of Sciences.

[15]  M. Tomishima,et al.  Therapeutic cloning in individual parkinsonian mice , 2008, Nature Medicine.

[16]  Yechiel Elkabetz,et al.  Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. , 2008, Genes & development.

[17]  Mark Shackleton,et al.  Efficient tumour formation by single human melanoma cells , 2008 .

[18]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[19]  R. McKay,et al.  The foxa2 Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age , 2007, PLoS biology.

[20]  J. Whitsett,et al.  Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner , 2007, Development.

[21]  M. Beal,et al.  Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes , 2006, Nature Medicine.

[22]  O. Isacson,et al.  Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP‐32 striatal progenitors within the graft , 2006, The European journal of neuroscience.

[23]  P. Gutin,et al.  Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain , 2005, Nature Biotechnology.

[24]  Robert A Pearce,et al.  Specification of motoneurons from human embryonic stem cells , 2005, Nature Biotechnology.

[25]  V. Tabar,et al.  Derivation of midbrain dopamine neurons from human embryonic stem cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  H. Kondoh,et al.  Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. , 2002, Genes & development.

[27]  J. Bloch,et al.  Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. , 2000, Science.

[28]  Jacqueline N. Crawley,et al.  What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice , 2000 .

[29]  A. Toga,et al.  The Rhesus Monkey Brain in Stereotaxic Coordinates , 1999 .

[30]  R. McKay,et al.  Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats , 1998, Nature Neuroscience.

[31]  B J Hoffer,et al.  Dopamine neuron agenesis in Nurr1-deficient mice. , 1997, Science.

[32]  C. Spenger,et al.  Noninvasive dopamine determination by reversed phase HPLC in the medium of free-floating roller tube cultures of rat fetal ventral mesencephalon: A tool to assess dopaminergic tissue prior to grafting , 1996, Brain Research Bulletin.

[33]  C. Olanow,et al.  Fetal nigral transplantation as a therapy for Parkinson's disease , 1996, Trends in Neurosciences.

[34]  T. Jessell,et al.  Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm , 1995, Cell.

[35]  T. Jessell,et al.  Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord , 1994, Cell.

[36]  I. Engberg,et al.  Nifedipine‐ and omega‐conotoxin‐sensitive Ca2+ conductances in guinea‐pig substantia nigra pars compacta neurones. , 1993, The Journal of physiology.

[37]  J E Darnell,et al.  Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes , 1989, Molecular and cellular biology.