Chromogranin A‐positive hormone‐negative endocrine cells in pancreas in human pregnancy

We sought to determine whether chromogranin A‐positive hormone‐negative (CPHN) endocrine cells are increased in the pancreas of pregnant women, offering potential evidence in support of neogenesis.

[1]  A. Butler,et al.  Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes , 2019, Current Diabetes Reports.

[2]  J. Locascio,et al.  Augmented insulin secretory response in early pregnancy , 2019, Diabetologia.

[3]  E. Dirice,et al.  Human duct cells contribute to β cell compensation in insulin resistance. , 2019, JCI insight.

[4]  Sarah Kim,et al.  Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes , 2019, Diabetologia.

[5]  V. Dolinsky,et al.  Maternal β-Cell Adaptations in Pregnancy and Placental Signalling: Implications for Gestational Diabetes , 2018, International journal of molecular sciences.

[6]  R. Rizza,et al.  An Increase in Chromogranin A-Positive, Hormone-Negative Endocrine Cells in Pancreas in Cystic Fibrosis , 2018, Journal of the Endocrine Society.

[7]  S. Dry,et al.  Increased Chromogranin A–Positive Hormone-Negative Cells in Chronic Pancreatitis , 2018, The Journal of clinical endocrinology and metabolism.

[8]  P. Herrera,et al.  Stress‐induced adaptive islet cell identity changes , 2016, Diabetes, obesity & metabolism.

[9]  R. Rizza,et al.  Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes. , 2016, The Journal of clinical endocrinology and metabolism.

[10]  P. Butler,et al.  Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes. , 2016, The Journal of clinical endocrinology and metabolism.

[11]  E. Norwitz,et al.  Impact of Systemic Inflammation on the Progression of Gestational Diabetes Mellitus , 2016, Current Diabetes Reports.

[12]  J. Ahnfelt-Rønne,et al.  Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo. , 2016, Molecular endocrinology.

[13]  M. Hebrok,et al.  Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease. , 2015, Cell stem cell.

[14]  R. Rizza,et al.  Beta-cell deficit in Obese Type 2 Diabetes, a Minor Role of Beta-cell Dedifferentiation and Degranulation , 2015 .

[15]  T. Otonkoski,et al.  EGFR Signaling Promotes β-Cell Proliferation and Survivin Expression during Pregnancy , 2014, PloS one.

[16]  P. Catalano.  Trying to understand gestational diabetes , 2014, Diabetic medicine : a journal of the British Diabetic Association.

[17]  K. Akagawa,et al.  Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy , 2013, Proceedings of the National Academy of Sciences.

[18]  D. Coustan,et al.  Gestational diabetes mellitus. , 2013, Clinical chemistry.

[19]  C. Cobelli,et al.  Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy , 2010, Diabetologia.

[20]  J. Schug,et al.  The transcriptional response of the islet to pregnancy in mice. , 2009, Molecular endocrinology.

[21]  Regina K. Gorski,et al.  Expansion of adult β-cell mass in response to increased metabolic demand is dependent on HNF-4α , 2007 .

[22]  Robert A Rizza,et al.  Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. , 2003, Diabetes.

[23]  M. Atkinson,et al.  Type 1 diabetes: new perspectives on disease pathogenesis and treatment , 2001, The Lancet.

[24]  R. Sorenson,et al.  Adaptation of Islets of Langerhans to Pregnancy: β-Cell Growth, Enhanced Insulin Secretion and the Role of Lactogenic Hormones , 1997, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[25]  J. Parsons,et al.  Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. , 1992, Endocrinology.

[26]  L. Aerts,et al.  A MORPHOLOGICAL STUDY OF THE ENDOCRINE PANCREAS IN HUMAN PREGNANCY , 1978, British journal of obstetrics and gynaecology.